Germline DNMT3A mutation in familial acute myeloid leukaemia by Courtney D. DiNardo, Hannah C. Beird, Marcos Estecio, Swanand Hardikar, Koichi Takahashi, Sarah A. Bannon, Gautam Borthakur, Elias Jabbour, Curtis Gumbs, Joseph D. Khoury, Mark Routbort, Ting Gong, Kimie Kondo, Hagop Kantarjian, Guillermo Garcia-Manero, Taiping Chen, P. Andrew Futreal

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P373: UPDATES FROM A PHASE II TRIAL OF MINI-HYPER-CVD-INOTUZUMAB WITH OR WITHOUT BLINATUMOMAB IN OLDER PATIENTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME (PH)-NEGATIVE ACUTE LYM... by Fadi Haddad, Elias Jabbour, Cedric Nasnas, Nicholas Short, Lewis Nasr, Walid Macaron, Marianne Zoghbi, Farhad Ravandi, Nitin Jain, Tapan Kadia, Naval Daver, Gautam Borthakur, Courtney Dinardo, Jovitta Jacob, Edith Roy, Christopher Loiselle, Anna Milton, Juan Rivera, Rebecca Garris, Hagop Kantarjian

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P364: A PHASE II STUDY OF LOW-INTENSITY CHEMOTHERAPY (MINI-HYPER-CVD) AND PONATINIB FOLLOWED BY BLINATUMOMAB AND PONATINIB IN PATIENTS WITH PHILADELPHIA CHROMOSOME-POSITIVE ACUTE L... by Fadi Haddad, Elias Jabbour, Lewis Nasr, Nicholas Short, Walid Macaron, Cedric Nasnas, Marianne Zoghbi, Ghayas Issa, Musa Yilmaz, Naval Daver, Naveen Pemmaraju, Lucia Masarova, Farhad Ravandi, Nitin Jain, Wuliamatu Deen, Christopher Loiselle, Lourdes Waller, Glenda Banks, Rebecca Garris, Hagop Kantarjian

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P535: OUTCOMES OF INVESTIGATIONAL AGENTS VS STANDARD THERAPIES IN AML AT SALVAGE 2 AND BEYOND by Daniel Nguyen, Hagop Kantarjian, Aram Bidikian, Courtney Dinardo, Tapan Kadia, Naval Daver, Gautam Borthakur, Elias Jabbour, Musa Yilmaz, Nicholas Short, Abhishek Maiti, Koji Sasaki, Guillermo Montalban-Bravo, Danielle Hammond, Sherry Pierce, Michael Andreeff, Guillermo Garcia-Manero, Farhad Ravandi, Ghayas Issa

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S119: COMBINATION OF MINI-HYPER-CVD AND INOTUZUMAB (INO) FOLLOWED BY BLINATUMOMAB (BLINA) CONSOLIDATION IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) ACUTE LYMPHOBLASTIC LEUKEMIA (ALL... by Fadi Haddad, Elias Jabbour, Cedric Nasnas, Nicholas Short, Walid Macaron, Marianne Zoghbi, Lewis Nasr, Nitin Jain, Emmanuel Almanza, Koji Sasaki, Farhad Ravandi, Partow Kebriaei, Xuelin Huang, Guillermo Garcia-Manero, Tapan Kadia, Sa Wang, Jovitta Jacob, Rebecca Garris, Susan O’brien, Hagop Kantarjian

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P377: A PHASE II TRIAL OF MINI-HYPER-CVD WITH VENETOCLAX FOR PATIENTS WITH RELAPSED/REFRACTORY (R/R) PHILADELPHIA CHROMOSOME (PH)-NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) by Fadi Haddad, Elias Jabbour, Marianne Zoghbi, Nicholas Short, Jayastu Senapati, Walid Macaron, Cedric Nasnas, Lewis Nasr, Naveen Pemmaraju, Nitin Jain, William G. Wierda, Gautam Borthakur, Guillermo Montalban-Bravo, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Kelly Chien, Jennifer Thankachan, Rebecca Garris, Hagop Kantarjian

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P730: EVOLUTION OF IPSS-M RISK CATEGORIES IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES FROM DIAGNOSIS TO HYPOMETHYLATING AGENT FAILURE by Kelly Chien, Samuel Urrutia, Ziyi LI, Rashmi Kanagal-Shamanna, Emmanuel Almanza, Tareq Abuasab, Georgina Gener, Alex Bataller, Alexandre Bazinet, Guillermo Montalban-Bravo, Nicholas Short, Elias Jabbour, Tapan Kadia, Farhad Ravandi, Gautam Borthakur, Danielle Hammond, Mahesh Swaminathan, Koji Sasaki, Sherry Pierce, Hagop Kantarjian, Guillermo Garcia-Manero

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P736: ANALYSIS OF RESPONSE RATES AND OUTCOMES IN ERYTHROID-PREDOMINANT MYELODYSPLASTIC SYNDROMES (MDS) TREATED WITH VENETOCLAX-BASED REGIMENS by Alexandre Bazinet, Naszrin Arani, Kelly Chien, Danielle Hammond, Tapan Kadia, Gautam Borthakur, Yesid Alvarado, Koji Sasaki, Courtney Dinardo, Naveen Pemmaraju, Lucia Masarova, Nicholas Short, Musa Yilmaz, Naval Daver, Elias Jabbour, Farhad Ravandi, Rashmi Kanagal-Shamanna, Sherry Pierce, Hagop Kantarjian, Guillermo Garcia-Manero, Guillermo Montalban-Bravo

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Venetoclax for Children and Adolescents with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma by Amber Gibson, Adriana Trabal, David McCall, Sajad Khazal, Laurie Toepfer, Donna H. Bell, Michael Roth, Kris M. Mahadeo, Cesar Nunez, Nicholas J. Short, Courtney DiNardo, Marina Konopleva, Ghayas C. Issa, Farhad Ravandi, Nitin Jain, Gautam Borthakur, Hagop M. Kantarjian, Elias Jabbour, Branko Cuglievan

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Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia by Hagop Kantarjian, Fadi G. Haddad, Nitin Jain, Koji Sasaki, Nicholas J. Short, Sanam Loghavi, Rashmi Kanagal-Shamanna, Jeffrey Jorgensen, Issa Khouri, Partow Kebriaei, Yesid Alvarado, Tapan Kadia, Shilpa Paul, Guillermo Garcia-Manero, Bouthaina Dabaja, Musa Yilmaz, Jovitta Jacob, Rebecca Garris, Susan O’Brien, Farhad Ravandi, Elias Jabbour

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S110: PHALLCON: A PHASE 3 STUDY COMPARING PONATINIB VERSUS IMATINIB IN NEWLY DIAGNOSED PH+ ALL by Elias Jabbour, Hagop Kantarjian, Ibrahim Aldoss, Pau Montesinos, Jessica Leonard, David Gomez, Maria Baer, Carlo Gambacorti-Passerini, James Mccloskey, Yosuke Minami, Cristina Papayannidis, Vanderson Rocha, Philippe Rousselot, Pankit Vachhani, Eunice Wang, Meliessa Hennessy, Niti Patel, Alexander Vorog, Bingxia Wang, Huilan Yao, Tammie Yeh, Josep Maria Ribera

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P496: PHENOTYPIC SUBTYPES OF LEUKEMIC TRANSFORMATION IN CHRONIC MYELOMONOCYTIC LEUKEMIA by Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Ziyi LI, Danielle Hammond, Kelly Chien, Juan Jose Rodriguez-Sevilla, Koji Sasaki, Elias Jabbour, Courtney Dinardo, Koichi Takahashi, Nicholas Short, Ghayas Issa, Tapan Kadia, Naveen Pemmaraju, Farhad Ravandi, Naval Daver, Gautam Borthakur, Sanam Loghavi, Sherry Pierce, Carlos Bueso Ramos, Guillermo Garcia-Manero

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P723: CLINICAL AND MOLECULAR ASSOCIATIONS WITH OUTCOMES IN HIGHER RISK MYELODYSPLASTIC SYNDROMES TREATED WITH HYPOMETHYLATING AGENTS PLUS VENETOCLAX by Alexandre Bazinet, Sai Prasad Desikan, Ziyi LI, Sangeetha Venugopal, Samuel Urrutia, Guillermo Montalban-Bravo, Koji Sasaki, Kelly Chien, Danielle Hammond, Rashmi Kanagal-Shamanna, Bailey Mirabella, Stephany Hendrickson, Liz Romero, Simona Colla, Irene Ganan-Gomez, Juan Jose Rodriguez-Sevilla, Tapan Kadia, Courtney Dinardo, Naval Daver, Elias Jabbour, Farhad Ravandi, Hagop Kantarjian, Guillermo Garcia-Manero

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Hypomethylating agent and venetoclax with FLT3 inhibitor “triplet” therapy in older/unfit patients with FLT3 mutated AML by Musa Yilmaz, Hagop Kantarjian, Nicholas J. Short, Patrick Reville, Marina Konopleva, Tapan Kadia, Courtney DiNardo, Gautam Borthakur, Naveen Pemmaraju, Abhishek Maiti, Elias Jabbour, Nitin Jain, Ghayas Issa, Koichi Takahashi, Koji Sasaki, Maro Ohanian, Sherry Pierce, Guillin Tang, Sanam Loghavi, Keyur Patel, Sa A. Wang, Guillermo Garcia-Manero, Michael Andreeff, Farhad Ravandi, Naval Daver

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P379: PONATINIB AND BLINATUMOMAB IN RELAPSED/REFRACTORY PHILADELPHIA-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA OR CHRONIC MYELOID LEUKEMIA IN LYMPHOID BLAST PHASE: SUBGROUP ANALYSIS FR... by Fadi Haddad, Elias Jabbour, Marianne Zoghbi, Nicholas Short, Cedric Nasnas, Lewis Nasr, Walid Macaron, Nitin Jain, Xuelin Huang, Guillermo Montalban-Bravo, Tapan Kadia, Naval Daver, Kelly Chien, Yesid Alvarado, Guillermo Garcia-Manero, Ghayas Issa, Monica Kwari, Ricardo Delumpa, Ejiroghene Mayor, Wuliamatu Deen, Jennifer Thankachan, Christopher Loiselle, Juan Rivera, Anna Milton, Lourdes Waller, Glenda Banks, Rebecca Garris, Farhad Ravandi, Hagop Kantarjian

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A phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents by Nicholas J. Short, Muharrem Muftuoglu, Faustine Ong, Lewis Nasr, Walid Macaron, Guillermo Montalban-Bravo, Yesid Alvarado, Mahesh Basyal, Naval Daver, Courtney D. Dinardo, Gautam Borthakur, Nitin Jain, Maro Ohanian, Elias Jabbour, Ghayas C. Issa, Wei Qiao, Xuelin Huang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Prithviraj Bose, Farhad Ravandi, Ricardo Delumpa, Regina Abramova, Guillermo Garcia-Manero, Michael Andreeff, Jorge Cortes, Hagop Kantarjian

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S262: SAFETY AND EFFICACY OF OBECABTAGENE AUTOLEUCEL (OBE-CEL), A FAST-OFF RATE CD19 CAR IN RELAPSED/REFRACTORY ADULT B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA:TOP LINE RESULTS OF THE P... by Claire Roddie, Karamjeet Sandhu, Eleni Tholouli, Paul Shaughnessy, Pere Barba Suñol, Manuel Nuno Direito de Morais Guerreiro, Mehrdad Abedi, Michael Bishop, Jean Yared, Armin Ghobadi, Deborah Yallop, Aaron Logan, Beitinjaneh Amer, Jeremy Pantin, Martha L Arellano, Sridhar Chaganti, Ram Malladi, Tobias Menne, Virginia Escamilla, Katharine Hodby, Krishna Gundabolu, Luke Mountjoy, Kristen Odwyer, Sameem Abedin, Hassan Alkhateeb, Bijal Shah, Silvia Basilico, Deborah Cluxton, Joanna Dawes, Pierre Lao-Sirieix, Meera Raymond, Justin Shang, Yanqing Hu, Gianfranco Pittari, Kapil Saxena, Wolfram Brugger, Y Zhang, Martin Pule, Daniel Park, Daniel De Angelo, Elias Jabbour

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