Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model by Wing, PAC, Prange-Barczynska, M, Cross, A, Crotta, S, Orbegozo Rubio, C, Cheng, X, Harris, J, Zhuang, X, Johnson, R, Ryan, K, Hall, Y, Carroll, M, Issa, F, Balfe, P, Wack, A, Bishop, T, Salguero, F, McKeating, J

Impact of hepatitis C virus seropositivity on survival after allogeneic hematopoietic stem cell transplantation for hematologic malignancies by Carlos A. Ramos, Rima M. Saliba, Leandro de Pádua, Ola Khorshid, Elizabeth J. Shpall, Sergio Giralt, Poliana A. Patah, Chitra M. Hosing, Uday R. Popat, Gabriela Rondon, Issa F. Khouri, Yago L. Nieto, Richard E. Champlin, Marcos de Lima

Get full text

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus by Downes, DJ, Cross, AR, Hua, P, Roberts, N, Schwessinger, R, Cutler, AJ, Munis, AM, Brown, J, Mielczarek, O, de Andrea, CE, Melero, I, Gill, DR, Hyde, SC, Knight, JC, Todd, JA, Sansom, SN, Issa, F, Davies, JOJ, Hughes, JR

Impact of graft composition on outcomes of haploidentical bone marrow stem cell transplantation by Rima M. Saliba, Lauren Veltri, Gabriela Rondon, Julianne Chen, Gheath Al-Atrash, Amin Alousi, Charles Martinez, LaJerald Augustine, Chitra M. Hosing, Betul Oran, Katayoun Rezvani, Elisabeth J. Shpall, Partow Kebriaei, Issa F. Khouri, Uday Popat, Richard E. Champlin, Stefan O. Ciurea

Get full text

Fludarabine-melphalan as a preparative regimen for reduced-intensity conditioning allogeneic stem cell transplantation in relapsed and refractory Hodgkin’s lymphoma: the updated M.... by Paolo Anderlini, Rima Saliba, Sandra Acholonu, Sergio A. Giralt, Borje Andersson, Naoto T. Ueno, Chitra Hosing, Issa F. Khouri, Daniel Couriel, Marcos de Lima, Muzaffar H. Qazilbash, Barbara Pro, Jorge Romaguera, Luis Fayad, Frederick Hagemeister, Anas Younes, Mark F. Munsell, Richard E. Champlin

Get full text

A phase I study of romidepsin and ifosfamide, carboplatin, etoposide for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma by Paolo Strati, Dai Chihara, Yasuhiro Oki, Luis E Fayad, Nathan Fowler, Loretta Nastoupil, Jorge E Romaguera, Felipe Samaniego, Naveen Garg, Lei Feng, Emily T. Wesson, Charnelle E. Ruben, Mildred D. Stafford, Yago Nieto, Issa F Khouri, Chitra Hosing, Sandra B. Horowitz, Rammurti T-. Kamble, Michelle A. Fanale

Get full text

Feasibility, long‐term safety and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients by Harden, PN, Game, D, Sawitzki, B, Van der Net, J, Hester, J, Bushell, A, Issa, F, Brook, MO, Alzhrani, A, Schlickeiser, S, Scotta, C, Petchey, W, Blancho, G, Tang, Q, Markmann, J, Lechler, RI, Roberts, IR, Friend, P, Hilton, R, Geissler, EK, Wood, KJ, Lombardi, G

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73 by Jarvis, LB, Rainbow, DB, Coppard, V, Howlett, SK, Georgieva, Z, Davies, JL, Mullay, HK, Hester, J, Ashmore, T, Van den Bosch, A, Grist, JT, Coles, AJ, Mousa, HS, Pluchino, S, Mahbubani, KT, Griffin, JL, Saeb-Parsy, K, Issa, F, Peruzzotti-Jametti, L, Wicker, LS, Jones, JL

Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism by Cavounidis, A, Pandey, S, Capitani, M, Friedrich, M, Cross, A, Gartner, L, Aschenbrenner, D, Kim-Schulze, S, Lam, YK, Berridge, G, McGovern, DPB, Kessler, B, Fischer, R, Klenerman, P, Hester, J, Issa, F, Torres, EA, Powrie, F, Gochuico, BR, Gahl, WA, Cohen, L, Uhlig, HH

Banff 2019 Meeting Report: Molecular diagnostics in solid organ transplantation–Consensus for the Banff Human Organ Transplant (B‐HOT) gene panel and open source multicenter valida... by Mengel, M, Loupy, A, Haas, M, Roufosse, C, Naesens, M, Akalin, E, Clahsen-van Groningen, MC, Dagobert, J, Demetris, AJ, Duong van Huyen, JP, Gueguen, J, Issa, F, Robin, B, Rosales, I, Von der Thüsen, JH, Sanchez-Fueyo, A, Smith, RN, Wood, K, Adam, B, Colvin, RB

Poor antibody responses to SARS-CoV-2 infection or vaccination are associated with high re-infection rates in haemodialysis and renal transplant patients by Shankar, S, Beckett, J, Tipton, T, Ogbe, A, Kasanyinga, M, Dold, C, Lumley, S, Dengu, F, Rompianesi, G, Elgilani, F, Longet, S, Deeks, A, Payne, RP, Duncan, CJA, Richter, AG, Silva, TI, Turtle, L, Bull, K, Barnardo, M, Dunachie, S, Hester, J, Friend, P, Issa, F, Barnes, E, Carroll, MW, Klenerman, P

Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans by Lim, TY, Perpinan, E, Carlota Londono, M, Miquel, R, Ruiz, P, Kurt, A, Codela, E, Cross, A, Berlin, C, Hester, J, Issa, F, Douiri, A, Volmer, F, Taubert, R, Williams, E, Demetris, J, Lesniak, A, Bensimon, G, Lozano, J, Martinez-Llordella, M, Tree, T, Sanchez-Fueyo, A

Systemic silencing of PHD2 causes reversible immune regulatory dysfunction by Yamamoto, A, Hester, J, Macklin, P, Kawai, K, Uchiyama, M, Biggs, D, Bishop, T, Bull, K, Cheng, X, Cawthorne, E, Coleman, M, Crockford, T, Davies, B, Dow, L, Goldin, R, Kranc, K, Kudo, H, Lawson, H, McAuliffe, J, Milward, K, Scudamore, C, Soilleux, E, Issa, F, Ratcliffe, P, Pugh, C

SARS-CoV-2-specific T cell responses are not associated with protection against reinfection in hemodialysis patients by Shankar, S, Beckett, J, Tipton, T, Ogbe, A, Kasanyinga, M, Dold, C, Lumley, S, Dengu, F, Rompianesi, G, Elgilani, F, Longet, S, Deeks, A, Payne, RP, Duncan, CJA, Richter, A, de Silva, TI, Turtle, L, Bull, K, Barnardo, M, Friend, PJ, Dunachie, SJ, Hester, J, Issa, F, Barnes, E, Carroll, MW, Klenerman, P

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection by VanDyke, D, Iglesias, M, Tomala, J, Young, A, Smith, J, Perry, JA, Gebara, E, Cross, AR, Cheung, LS, Dykema, AG, Orcutt-Jahns, BT, Henclová, T, Golias, J, Balolong, J, Tomasovic, LM, Funda, D, Meyer, AS, Pardoll, DM, Hester, J, Issa, F, Hunter, CA, Anderson, MS, Bluestone, JA, Raimondi, G, Spangler, JB

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection by VanDyke, D, Iglesias, M, Tomala, J, Young, A, Smith, J, Perry, J, Gebara, E, Cross, A, Cheung, L, Dykema, A, Orcutt-Jahns, B, Henclová, T, Golias, J, Balolong, J, Tomasovic, L, Funda, D, Meyer, A, Pardoll, D, Hester, J, Issa, F, Hunter, C, Anderson, M, Bluestone, J, Raimondi, G, Spangler, J

Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs by Weeratunga, P, Denney, L, Bull, J, Repapi, E, Sergeant, M, Etherington, R, Vuppusetty, C, Turner, GDH, Woo, J, Cross, A, Issa, F, Sims, D, Mcgowan, S, Zurke, Y, Ahern, D, Cano Gamez, E, Whalley, J, Richards, D, Klenerman, P, Monaco, C, Udalova, I, Dong, T, Antanaviciute, A, Ogg, G, Knight, J, Byrne, H, Taylor, S, Ho, LP

Neutrophil extracellular traps, local IL-8 expression, and cytotoxic T-lymphocyte absence in the lungs of fatal COVID-19: a retrospective histopathology cohort study by Melero, I, Villalba-Esparza, M, Recalde-Zamacona, B, Álvaro, T, Argueta, A, García-Tobar, L, Álvarez-Gigli, L, Sainz, C, Garcia-Ros, D, Toledo, E, Abengozar-Muela, M, Fernandez-Alonso, M, Rodriguez-Moreno, M, Reina, G, Carmona-Torre, F, Quiroga, JA, Pozo, JD, Cross, A, Echeveste, J, Lozano, M, Ho, L-P, Klenerman, P, Issa, F, Landecho, M, Andrea, CD

A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer by Fletcher, CE, Deng, L, Orafidiya, F, Yuan, W, Lorentzen, MPGS, Cyran, OW, Varela-Carver, A, Constantin, TA, Leach, DA, Dobbs, FM, Figueiredo, I, Gurel, B, Parkes, E, Bogdan, D, Pereira, RR, Zhao, SG, Neeb, A, Issa, F, Hester, J, Kudo, H, Liu, Y, Philippou, Y, Bristow, R, Knudsen, K, Bryant, RJ, Feng, FY, Reed, SH, Mills, IG, de Bono, J, Bevan, CL

Unbiased single cell spatial analysis localises inflammatory clusters of immature neutrophils-CD8 T cells to alveolar progenitor cells in fatal COVID-19 lungs by COSMIC – COVID-19 Lung Single Cell Mass Cytometry Imaging Consortium STUDY, Weeratunga, P, Denney, L, Bull, J, Repapi, E, Sergeant, M, Etherington, R, Vuppussetty, C, Turner, GDH, Clelland, C, Cross, A, Issa, F, de Andrea, CE, Bermejo, IM, Sims, D, McGowan, S, Zurke, Y-X, Ahern, D, Gamez, E, Whalley, J, Richards, D, Klenerman, P, Monaco, C, Udalova, IA, Dong, T, Ogg, G, Knight, J, Byrne, H, Taylor, S, Ho, L-P