Manolis Kellis

Manolis Kellis at the [[American Society of Human Genetics]] (ASHG) meeting in Orlando Florida on October 19, 2017 Manolis Kellis (; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.

Kellis is known for his contributions to genomics, human genetics, epigenomics, gene regulation, genome evolution, disease mechanism, and single-cell genomics. He co-led the NIH Roadmap Epigenomics Project effort to create a comprehensive map of the human epigenome, the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome, the ENCODE, GENCODE, and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms. A major focus of his work is understanding the effects of genetic variations on human disease, with contributions to obesity, diabetes, Alzheimer's disease, schizophrenia, and cancer. Provided by Wikipedia
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  1. 201
    PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells

    PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells by Das, Partha Pratim, Hendrix, David A., Apostolou, Effie, Buchner, Alice H., Canver, Matthew C., Beyaz, Semir, Ljuboja, Damir, Kuintzle, Rachael, Kim, Woojin, Karnik, Rahul, Shao, Zhen, Xie, Huafeng, Xu, Jian, De Los Angeles, Alejandro, Zhang, Yingying, Choe, Junho, Jun, Don Leong Jia, Shen, Xiaohua, Gregory, Richard I., Daley, George Q., Meissner, Alexander, Kellis, Manolis, Hochedlinger, Konrad, Kim, Jonghwan, Orkin, Stuart H., Hendrix, David A.

    Published 2016
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  2. 202
    The GENCODE human gene set

    The GENCODE human gene set by Searle, S., Frankish, A., Bignell, A., Aken, B., Derrien, Thomas, Diekhans, M., Harte, R., Howald, C., Kokocinski, F., Lin, M., Tress, M., Van Baren, M., Barnes, I., Hunt, T., Carvalho-Silva, D., Davidson, C., Donaldson, S., Gilbert, J., Kay, M., Lloyd, D., Loveland, J., Mudge, J., Snow, C., Vamathevan, J., Wilming, L., Brent, M., Gerstein, Mark B., Guigo, Roderic, Kellis, Manolis, Reymond, A., Zadissa, A., Valencia, A., Harrow, J., Hubbard, T.

    Published 2012
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  3. 203
    APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

    APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes by Blanchard, Joel W, Akay, Leyla Anne, Davila-Velderrain, Jose, von Maydell, Djuna, Mathys, Hansruedi, Davidson, Shawn M, Effenberger, Audrey, Chen, Chih-Yu, Maner-Smith, Kristal, Hajjar, Ihab, Ortlund, Eric A, Bula, Michael, Agbas, Emre, Ng, Ayesha, Jiang, Xueqiao, Kahn, Martin, Blanco-Duque, Cristina, Lavoie, Nicolas, Liu, Liwang, Reyes, Ricardo, Lin, Yuan-Ta, Ko, Tak, R’Bibo, Lea, Ralvenius, William T, Bennett, David A, Cam, Hugh P, Kellis, Manolis, Tsai, Li-Huei

    Published 2023
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  4. 204
    Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

    Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci by Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Yu, Lei, Ernst, Jason, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Younkin, Curtis, Zou, Fanggeng, Szyf, Moshe, Meissner, Alexander, Ertekin-Taner, Nilufer, Kellis, Manolis, Mill, Jonathan, De Jager, Philip L., Schalkwyk, Leonard C., Eaton, Matthew Lucas, Eaton, Matthew L., Keenan, Brendan T., Ernst, Jason, Chai, High S., Younkin, Steven G., Epstein, Charles B., Schneider, Julie A., Bernstein, Bradley E., Chibnik, Lori B., Bennett, David A.

    Published 2016
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  5. 205
    Defining functional DNA elements in the human genome

    Defining functional DNA elements in the human genome by Kellis, Manolis, Wold, Barbara, Snyder, Michael P., Bernstein, Bradley E., Kundaje, Anshul, Marinov, Georgi K., Ward, Lucas D., Birney, Ewan, Crawford, Gregory E., Dekker, Job, Dunham, Ian, Elnitski, Laura L., Farnham, Peggy J., Feingold, Elise A., Gerstein, Mark B., Giddings, Morgan C., Gilbert, David M., Gingeras, Thomas R., Green, Eric D., Guigo, Roderic, Hubbard, Tim, Kent, Jim, Lieb, Jason D., Myers, Richard M., Pazin, Michael J., Ren, Bing, Stamatoyannopoulos, John A., Weng, Zhiping, White, Kevin P., Hardison, Ross C.

    Published 2014
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  6. 206
    Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

    Deep-coverage whole genome sequences and blood lipids among 16,324 individuals by Natarajan, Pradeep, Peloso, Gina M., Zekavat, Seyedeh Maryam, Montasser, May, Ganna, Andrea, Chaffin, Mark, Khera, Amit V., Zhou, Wei, Bloom, Jonathan M., Engreitz, Jesse M., Ernst, Jason, O’Connell, Jeffrey R., Ruotsalainen, Sanni E., Alver, Maris, Manichaikul, Ani, Johnson, W. Craig, Perry, James A., Poterba, Timothy, Seed, Cotton, Surakka, Ida L., Esko, Tonu, Ripatti, Samuli, Salomaa, Veikko, Correa, Adolfo, Vasan, Ramachandran S., Kellis, Manolis, Neale, Benjamin M., Lander, Eric S., Abecasis, Goncalo, Mitchell, Braxton, Rich, Stephen S., Wilson, James G., Cupples, L. Adrienne, Rotter, Jerome I., Willer, Cristen J., Kathiresan, Sekar

    Published 2020
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  7. 207
    Genus-wide characterization of bumblebee genomes provides insights into their evolution and variation in ecological and behavioral traits

    Genus-wide characterization of bumblebee genomes provides insights into their evolution and variation in ecological and behavioral traits by Sun, Cheng, Huang, Jiaxing, Wang, Yun, Zhao, Xiaomeng, Su, Long, Thomas, Gregg W C, Zhao, Mengya, Zhang, Xingtan, Jungreis, Irwin, Kellis, Manolis, Vicario, Saverio, Sharakhov, Igor V, Bondarenko, Semen M, Hasselmann, Martin, Kim, Chang N, Paten, Benedict, Penso-Dolfin, Luca, Wang, Li, Chang, Yuxiao, Gao, Qiang, Ma, Ling, Ma, Lina, Zhang, Zhang, Zhang, Hongbo, Zhang, Huahao, Ruzzante, Livio, Robertson, Hugh M, Zhu, Yihui, Liu, Yanjie, Yang, Huipeng, Ding, Lele, Wang, Quangui, Ma, Dongna, Xu, Weilin, Liang, Cheng, Itgen, Michael W, Mee, Lauren, Cao, Gang, Zhang, Ze, Sadd, Ben M, Hahn, Matthew, Schaack, Sarah, Barribeau, Seth M, Williams, Paul H, Waterhouse, Robert M, Mueller, Rachel Lockridge

    Published 2021
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  8. 208
    Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

    Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts by Huckins, Laura M., Chatzinakos, Chris, Breen, Michael S., Hartmann, Jakob, Klengel, Torsten, da Silva Almeida, Ana C., Dobbyn, Amanda, Girdhar, Kiran, Hoffman, Gabriel E., Klengel, Claudia, Logue, Mark W., Lori, Adriana, Maihofer, Adam X., Morrison, Filomene G., Nguyen, Hoang T., Park, YongJin, Ruderfer, Douglas, Sloofman, Laura G., van Rooij, Sanne J.H., Baker, Dewleen G., Chen, Chia-Yen, Cox, Nancy, Duncan, Laramie E., Geyer, Mark A., Glatt, Stephen J., Im, Hae Kyung, Risbrough, Victoria B., Smoller, Jordan W., Stein, Dan J., Yehuda, Rachel, Liberzon, Israel, Koenen, Karestan C., Jovanovic, Tanja, Kellis, Manolis, Miller, Mark W., Bacanu, Silviu-Alin, Nievergelt, Caroline M., Buxbaum, Joseph D., Sklar, Pamela, Ressler, Kerry J., Stahl, Eli A., Daskalakis, Nikolaos P., PTSD Working Group of Psychiatric Genomics Consortium

    Published 2021
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  9. 209
    GENCODE reference annotation for the human and mouse genomes

    GENCODE reference annotation for the human and mouse genomes by Frankish, Adam, Diekhans, Mark, Ferreira, Anne-Maud, Johnson, Rory, Jungreis, Irwin, Loveland, Jane, Mudge, Jonathan M, Sisu, Cristina, Wright, James, Armstrong, Joel, Barnes, If, Berry, Andrew, Bignell, Alexandra, Carbonell Sala, Silvia, Chrast, Jacqueline, Cunningham, Fiona, Di Domenico, Tomás, Donaldson, Sarah, Fiddes, Ian T, García Girón, Carlos, Gonzalez, Jose Manuel, Grego, Tiago, Hardy, Matthew, Hourlier, Thibaut, Hunt, Toby, Izuogu, Osagie G, Lagarde, Julien, Martin, Fergal J, Martínez, Laura, Mohanan, Shamika, Muir, Paul, Navarro, Fabio C P, Parker, Anne, Pei, Baikang, Pozo, Fernando, Ruffier, Magali, Schmitt, Bianca M, Stapleton, Eloise, Suner, Marie-Marthe, Sycheva, Irina, Uszczynska-Ratajczak, Barbara, Xu, Jinuri, Yates, Andrew, Zerbino, Daniel, Zhang, Yan, Aken, Bronwen, Choudhary, Jyoti S, Gerstein, Mark, Guigó, Roderic, Hubbard, Tim J P, Kellis, Manolis, Paten, Benedict, Reymond, Alexandre, Tress, Michael L, Flicek, Paul

    Published 2022
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  10. 210
    Expanded encyclopaedias of DNA elements in the human and mouse genomes

    Expanded encyclopaedias of DNA elements in the human and mouse genomes by Moore, Jill E., Purcaro, Michael J., Pratt, Henry E., Epstein, Charles B., Shoresh, Noam, Adrian, Jessika, Kawli, Trupti, Davis, Carrie A., Dobin, Alexander, Kaul, Rajinder, Halow, Jessica, Van Nostrand, Eric L., Freese, Peter Dale, Gorkin, David U., Shen, Yin, He, Yupeng, Mackiewicz, Mark, Pauli-Behn, Florencia, Williams, Brian A., Mortazavi, Ali, Keller, Cheryl A., Zhang, Xiao-Ou, Elhajjajy, Shaimae I., Huey, Jack, Dickel, Diane E., Snetkova, Valentina, Wei, Xintao, Wang, Xiaofeng, Rivera-Mulia, Juan Carlos, Rozowsky, Joel, Zhang, Jing, Chhetri, Surya B., Zhang, Jialing, Victorsen, Alec, White, Kevin P., Visel, Axel, Yeo, Gene W., Burge, Christopher B, Lécuyer, Eric, Gilbert, David M., Dekker, Job, Rinn, John, Mendenhall, Eric M., Ecker, Joseph R., Kellis, Manolis, Klein, Robert J., Noble, William S., Kundaje, Anshul, Guigó, Roderic, Farnham, Peggy J., Cherry, J. Michael, Myers, Richard M., Ren, Bing, Graveley, Brenton R., Gerstein, Mark B., Pennacchio, Len A., Snyder, Michael P., Bernstein, Bradley E., Wold, Barbara, Hardison, Ross C., Gingeras, Thomas R., Stamatoyannopoulos, John A., Weng, Zhiping

    Published 2021
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  11. 211
    Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

    Analyses of non-coding somatic drivers in 2,658 cancer whole genomes by Rheinbay, Esther, Nielsen, Morten Muhlig, Abascal, Federico, Wala, Jeremiah A., Shapira, Ofer, Tiao, Grace, Hornshøj, Henrik, Hess, Julian M., Juul, Randi Istrup, Lin, Ziao, Feuerbach, Lars, Sabarinathan, Radhakrishnan, Madsen, Tobias, Kim, Jaegil, Mularoni, Loris, Shuai, Shimin, Lanzós, Andrés, Herrmann, Carl, Maruvka, Yosef E., Shen, Ciyue, Amin, Samirkumar B., Bandopadhayay, Pratiti, Bertl, Johanna, Boroevich, Keith A., Busanovich, John, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Craft, David, Dhingra, Priyanka, Diamanti, Klev, Fonseca, Nuno A., Gonzalez-Perez, Abel, Guo, Qianyun, Hamilton, Mark P., Haradhvala, Nicholas J., Hong, Chen, Isaev, Keren, Johnson, Todd A., Juul, Malene, Kahles, Andre, Kahraman, Abdullah, Kim, Youngwook, Komorowski, Jan, Kumar, Kiran, Kumar, Sushant, Lee, Donghoon, Lehmann, Kjong-Van, Li, Yilong, Liu, Eric Minwei, Lochovsky, Lucas, Park, Keunchil, Pich, Oriol, Roberts, Nicola D., Saksena, Gordon, Schumacher, Steven E., Sidiropoulos, Nikos, Sieverling, Lina, Sinnott-Armstrong, Nasa, Stewart, Chip, Tamborero, David, Tubio, Jose M. C., Umer, Husen M., Uusküla-Reimand, Liis, Wadelius, Claes, Wadi, Lina, Yao, Xiaotong, Zhang, Cheng-Zhong, Zhang, Jing, Haber, James E., Hobolth, Asger, Imielinski, Marcin, Kellis, Manolis, Lawrence, Michael S., von Mering, Christian, Nakagawa, Hidewaki, Raphael, Benjamin J., Rubin, Mark A., Sander, Chris, Stein, Lincoln D., Stuart, Joshua M., Tsunoda, Tatsuhiko, Wheeler, David A., Johnson, Rory, Reimand, Jüri, Gerstein, Mark, Khurana, Ekta, Campbell, Peter J., López-Bigas, Núria, Weischenfeldt, Joachim, Beroukhim, Rameen, Martincorena, Iñigo, Pedersen, Jakob Skou, Getz, Gad

    Published 2022
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  12. 212
    52 Genetic Loci Influencing Myocardial Mass

    52 Genetic Loci Influencing Myocardial Mass by van der Harst, Pim, van Setten, Jessica, Verweij, Niek, Vogler, Georg, Franke, Lude, Maurano, Matthew T., Wang, Xinchen, Mateo Leach, Irene, Eijgelsheim, Mark, Sotoodehnia, Nona, Hayward, Caroline, Sorice, Rossella, Meirelles, Osorio, Lyytikäinen, Leo-Pekka, Polašek, Ozren, Tanaka, Toshiko, Arking, Dan E., Ulivi, Sheila, Trompet, Stella, Müller-Nurasyid, Martina, Smith, Albert V., Dörr, Marcus, Kerr, Kathleen F., Magnani, Jared W., Fabiola Del Greco, M., Zhang, Weihua, Nolte, Ilja M., Silva, Claudia T., Padmanabhan, Sandosh, Tragante, Vinicius, Esko, Tõnu, Abecasis, Gonçalo R., Adriaens, Michiel E., Andersen, Karl, Barnett, Phil, Bis, Joshua C., Bodmer, Rolf, Buckley, Brendan M., Campbell, Harry, Cannon, Megan V., Chakravarti, Aravinda, Chen, Lin Y., Delitala, Alessandro, Devereux, Richard B., Doevendans, Pieter A., Dominiczak, Anna F., Ferrucci, Luigi, Ford, Ian, Gieger, Christian, Harris, Tamara B., Haugen, Eric, Heinig, Matthias, Hernandez, Dena G., Hillege, Hans L., Hirschhorn, Joel N., Hofman, Albert, Hubner, Norbert, Hwang, Shih-Jen, Iorio, Annamaria, Kahonen, Mika, Kellis, Manolis, Kolcic, Ivana, Kooner, Ishminder K., Kooner, Jaspal S., Kors, Jan A., Lakatta, Edward G., Lage, Kasper, Launer, Lenore J., Levy, Daniel, Lundby, Alicia, Macfarlane, Peter W., May, Dalit, Meitinger, Thomas, Metspalu, Andres, Nappo, Stefania, Naitza, Silvia, Neph, Shane, Nord, Alex S., Nutile, Teresa, Okin, Peter M., Olsen, Jesper V., Oostra, Ben A., Penninger, Josef M., Pennacchio, Len A., Pers, Tune H., Perz, Siegfried, Peters, Annette, Pinto, Yigal M., Pfeufer, Arne, Pilia, Maria Grazia, Pramstaller, Peter P., Prins, Bram P., Raitakari, Olli T., Rice, Ken M., Rossin, Elizabeth J., Rotter, Jerome I., Schafer, Sebastian, Schlessinger, David, Schmidt, Carsten O., Sehmi, Jobanpreet, Silljé, Herman H.W., Sinagra, Gianfranco, Sinner, Moritz F., Slowikowski, Kamil, Soliman, Elsayed Z., Spector, Timothy D., Spiering, Wilko, Stamatoyannopoulos, John A., Stolk, Ronald P., Strauch, Konstantin, Tan, Sian-Tsung, Tarasov, Kirill V., Trinh, Bosco, Uitterlinden, Andre G., van den Boogaard, Malou, van Duijn, Cornelia M., van Gilst, Wiek H., Viikari, Jorma S., Visscher, Peter M., Vitart, Veronique, Völker, Uwe, Waldenberger, Melanie, Weichenberger, Christian X., Westra, Harm-Jan, Wijmenga, Cisca, Wolffenbuttel, Bruce H., Yang, Jian, Bezzina, Connie R., Munroe, Patricia B., Snieder, Harold, Wright, Alan F., Rudan, Igor, Boyer, Laurie A., Asselbergs, Folkert W., van Veldhuisen, Dirk J., Stricker, Bruno H., Psaty, Bruce M., Ciullo, Marina, Sanna, Serena, Lehtimäki, Terho, Wilson, James F., Bandinelli, Stefania, Alonso, Alvaro, Gasparini, Paolo, Jukema, J. Wouter, Kääb, Stefan, Gudnason, Vilmundur, Felix, Stephan B., Heckbert, Susan R., de Boer, Rudolf A., Newton-Cheh, Christopher, Hicks, Andrew A., Chambers, John C., Jamshidi, Yalda, Visel, Axel, Christoffels, Vincent M., Isaacs, Aaron, Samani, Nilesh J., de Bakker, Paul I.W.

    Published 2017
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  13. 213
    Computational dissection and prediction of cancer immunotherapy response

    Computational dissection and prediction of cancer immunotherapy response by Shi, Alvin

    Published 2022
    Other Authors: “…Kellis, Manolis…”
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  14. 214
    Gene-regulatory circuitry of disease risk and progression

    Gene-regulatory circuitry of disease risk and progression by Boix, Carles

    Published 2022
    Other Authors: “…Kellis, Manolis…”
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  15. 215
    Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy

    Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy by Fu, Ruiwen

    Published 2022
    Other Authors: “…Kellis, Manolis…”
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  16. 216
    A Transformer for scATAC-scRNA Translation

    A Transformer for scATAC-scRNA Translation by Jin, Roger

    Published 2023
    Other Authors: “…Kellis, Manolis…”
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  17. 217
    Single-cell differential splicing of Alzheimer’s Disease in 1.9 million cells across 416 individuals

    Single-cell differential splicing of Alzheimer’s Disease in 1.9 million cells across 416 individuals by Hwa, Christian

    Published 2023
    Other Authors: “…Kellis, Manolis…”
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  18. 218
    Statistical and Computational Methods to Dissect Ancestry-Biased Germline Effects in Lung Cancer

    Statistical and Computational Methods to Dissect Ancestry-Biased Germline Effects in Lung Cancer by Ismoldayeva, Assel

    Published 2023
    Other Authors: “…Kellis, Manolis…”
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  19. 219
    Correlation-based Linking of Epigenomic Regions to Target Genes in Bulk and Single Cell Epigenomic Data

    Correlation-based Linking of Epigenomic Regions to Target Genes in Bulk and Single Cell Epigenomic Data by James, Benjamin Thomas

    Published 2023
    Other Authors: “…Kellis, Manolis…”
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  20. 220
    Using heterogeneous Graph Neural Networks(hGNN) to predict cell-cell communication

    Using heterogeneous Graph Neural Networks(hGNN) to predict cell-cell communication by Yan, Binwei

    Published 2024
    Other Authors: “…Kellis, Manolis…”
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