Manolis Kellis

Manolis Kellis at the [[American Society of Human Genetics]] (ASHG) meeting in Orlando Florida on October 19, 2017 Manolis Kellis (; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.

Kellis is known for his contributions to genomics, human genetics, epigenomics, gene regulation, genome evolution, disease mechanism, and single-cell genomics. He co-led the NIH Roadmap Epigenomics Project effort to create a comprehensive map of the human epigenome, the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome, the ENCODE, GENCODE, and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms. A major focus of his work is understanding the effects of genetic variations on human disease, with contributions to obesity, diabetes, Alzheimer's disease, schizophrenia, and cancer. Provided by Wikipedia
Showing 101 - 120 results of 221 for search 'Kellis, Manolis', query time: 0.06s Refine Results
  1. 101
    Joint profiling of DNA methylation and chromatin architecture in single cells

    Joint profiling of DNA methylation and chromatin architecture in single cells by Li, Guoqiang, Liu, Yaping, Zhang, Yanxiao, Kubo, Naoki, Yu, Miao, Fang, Rongxin, Kellis, Manolis, Ren, Bing

    Published 2021
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  2. 102
    Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation

    Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation by Martinez-Gomez, Laura, Abascal, Federico, Jungreis, Irwin, Pozo, Fernando, Kellis, Manolis, Mudge, Jonathan M, Tress, Michael L

    Published 2021
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  3. 103
    A High-Resolution Map of Human Evolutionary Constraint Using 29 Mammals

    A High-Resolution Map of Human Evolutionary Constraint Using 29 Mammals by Mag Washietl, Stefan, Kheradpour, Pouya, Ernst, Jason, Ward, Lucas D., Jungreis, Irwin, Rasmussen, Matthew D., Kellis, Manolis

    Published 2012
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  4. 104
    Multi-scale chromatin state annotation using a hierarchical hidden Markov model

    Multi-scale chromatin state annotation using a hierarchical hidden Markov model by Huang, Jialiang, Glass, Kimberly, Pinello, Luca, Yuan, Guo-Cheng, Marco Rubio, Eugenio, Meuleman, Wouter, Wang, Jianrong, Kellis, Manolis

    Published 2017
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  5. 105
    High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human

    High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human by Goggin, Sarah M., Saadat, Alham, Wang, Li, Sinnott-Armstrong, Nasa, Wang, Xinchen, He, Liang, Kellis, Manolis, Claussnitzer, Melina

    Published 2019
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  6. 106
    Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon

    Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon by Khan, Yousuf A, Jungreis, Irwin, Wright, James C, Mudge, Jonathan M, Choudhary, Jyoti S, Firth, Andrew E, Kellis, Manolis

    Published 2020
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  7. 107
    Predictive Regulatory Models in of Transcriptional Networks

    Predictive Regulatory Models in of Transcriptional Networks by Kahveci, Tamer, Marbach, Daniel, Roy, Sushmita, Ay, Ferhat, Meyer, Patrick E., Candeias, Rogerio, Bristow, Christopher A., Kellis, Manolis

    Published 2012
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  8. 108
    New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes

    New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes by Kellis, Manolis, Parker, Brian J., Moltke, Ida, Roth, Adam, Washietl, Stefan, Wen, Jiayu, Breaker, Ronald, Pedersen, Jakob Skou

    Published 2012
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  9. 109
    A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)

    A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS) by Pery, Erez, Enghuus, Casper, Palacios, Sebastian R., Zhang, Zhizhuo, Novoa, Eva Maria, Kellis, Manolis, Weiss, Ron, Lu, Timothy K.

    Published 2020
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  10. 110
    Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets

    Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets by Berger, Emily, Yorukoglu, Deniz, Zhang, Lillian, Nyquist, Sarah Kate, Shalek, Alexander K, Kellis, Manolis, Numanagic, Ibrahim, Berger Leighton, Bonnie

    Published 2022
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  11. 111
    Stop codon readthrough generates a C-terminally extended variant of the human vitamin D receptor with reduced calcitriol response

    Stop codon readthrough generates a C-terminally extended variant of the human vitamin D receptor with reduced calcitriol response by Loughran, Gary, Jungreis, Irwin, Tzani, Ioanna, Power, Michael, Dmitriev, Ruslan I, Ivanov, Ivaylo P, Kellis, Manolis, Atkins, John F

    Published 2021
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  12. 112
    Stop codon readthrough generates a C-terminally extended variant of the human vitamin D receptor with reduced calcitriol response

    Stop codon readthrough generates a C-terminally extended variant of the human vitamin D receptor with reduced calcitriol response by Loughran, Gary, Jungreis, Irwin, Tzani, Ioanna, Power, Michael, Dmitriev, Ruslan I, Ivanov, Ivaylo P, Kellis, Manolis, Atkins, John F

    Published 2022
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  13. 113
    Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

    Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease by Glorioso, Christin A, Pfenning, Andreas R, Lee, Sam S, Bennett, David A, Sibille, Etienne L, Kellis, Manolis, Guarente, Leonard P

    Published 2021
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  14. 114
    Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

    Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease by Glorioso, Christin A., Pfenning, Andreas R, Lee, Sam S, Bennett, David A, Sibille, Etienne L, Kellis, Manolis, Guarente, Leonard Pershing

    Published 2022
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  15. 115
    Genetic drivers of m6A methylation in human brain, lung, heart and muscle

    Genetic drivers of m6A methylation in human brain, lung, heart and muscle by Xiong, Xushen, Hou, Lei, Park, Yongjin P, Molinie, Benoit, Ardlie, Kristin G, Aguet, François, Gregory, Richard I, Kellis, Manolis

    Published 2022
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  16. 116
    Evidence of abundant stop codon readthrough in Drosophila and other Metazoa

    Evidence of abundant stop codon readthrough in Drosophila and other Metazoa by Jungreis, Irwin, Lin, Michael F., Spokony, Rebecca, Chan, Clara Sophia, Negre, Nicolas, Victorsen, Alec, White, Kevin P., Kellis, Manolis

    Published 2012
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  17. 117
    Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

    Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay by Kheradpour, Pouya, Kellis, Manolis, Ernst, Jason, Melnikov, Alexandre, Rogov, Peter, Wang, Li, Zhang, Xiaolan, Alston, Jessica, Mikkelsen, Tarjei Sigurd

    Published 2013
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  18. 118
    Context influences on TALE–DNA binding revealed by quantitative profiling

    Context influences on TALE–DNA binding revealed by quantitative profiling by Rogers, Julia M., Reyon, Deepak, Sander, Jeffry D., Kellis, Manolis, Joung, J. Keith, Bulyk, Martha L., Barrera, Luis Alberto

    Published 2015
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  19. 119
    Corrigendum: Loose ends: almost one in five human genes still have unresolved coding status

    Corrigendum: Loose ends: almost one in five human genes still have unresolved coding status by Abascal, Federico, Juan, David, Jungreis, Irwin, Kellis, Manolis, Martinez, Laura, Rigau, Maria, Rodriguez, Jose Manuel, Vazquez, Jesus, Tress, Michael L

    Published 2020
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  20. 120
    Sex differences in oncogenic mutational processes

    Sex differences in oncogenic mutational processes by Li, Constance H., Prokopec, Stephenie D., Sun, Ren X., Yousif, Fouad, Schmitz, Nathaniel, Boutros, Paul C., Kellis, Manolis, PCAWG Consortium

    Published 2021
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