Manolis Kellis

Manolis Kellis at the [[American Society of Human Genetics]] (ASHG) meeting in Orlando Florida on October 19, 2017 Manolis Kellis (; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.

Kellis is known for his contributions to genomics, human genetics, epigenomics, gene regulation, genome evolution, disease mechanism, and single-cell genomics. He co-led the NIH Roadmap Epigenomics Project effort to create a comprehensive map of the human epigenome, the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome, the ENCODE, GENCODE, and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms. A major focus of his work is understanding the effects of genetic variations on human disease, with contributions to obesity, diabetes, Alzheimer's disease, schizophrenia, and cancer. Provided by Wikipedia
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  1. 121
    Optimization of parameters for coverage of low molecular weight proteins

    Optimization of parameters for coverage of low molecular weight proteins by Muller, Stephan A., Kohajda, Tibor, Findeiß, Sven, Stadler, Peter F., Mag Washietl, Stefan, Kellis, Manolis, Bergen, Martin von, Kalkhof, Stefan

    Published 2011
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  2. 122
    Arboretum: Reconstruction and analysis of the evolutionary history of condition-specific transcriptional modules

    Arboretum: Reconstruction and analysis of the evolutionary history of condition-specific transcriptional modules by Kellis, Manolis, Regev, Aviv, Roy, Sushmita, Wapinski, Ilan, Pfiffner, Jenna, French, Courtney, Socha, Amanda, Konieczka, Jay, Habib, Naomi, Thompson, Dawn

    Published 2014
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  3. 123
    BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1

    BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1 by Singh, Neeraj, Benoit, Marc R, Zhou, John, Das, Brati, Davila-Velderrain, Jose, Kellis, Manolis, Tsai, Li-Huei, Hu, Xiangyou, Yan, Riqiang

    Published 2022
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  4. 124
    Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence

    Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence by Meuleman, Wouter, Peric-Hupkes, Daan, Kind, Jop, Beaudry, Jean-Bernard, Pagie, Ludo, Kellis, Manolis, Reinders, Marcel, Wessels, Lodewyk, van Steensel, Bas

    Published 2013
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  5. 125
    Evidence of efficient stop codon readthrough in four mammalian genes

    Evidence of efficient stop codon readthrough in four mammalian genes by Loughran, Gary, Chou, Ming-Yuan, Ivanov, Ivaylo P., Jungreis, Irwin, Kellis, Manolis, Kiran, Anmol M., Baranov, Pavel V., Atkins, John F.

    Published 2014
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  6. 126
    Alzheimer's loci: epigenetic associations and interaction with genetic factors

    Alzheimer's loci: epigenetic associations and interaction with genetic factors by Chibnik, Lori B., Yu, Lei, Srivastava, Gyan, Schneider, Julie A., Kellis, Manolis, Bennett, David A., De Jager, Philip L., Eaton, Matthew Lucas

    Published 2016
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  7. 127
    Target site specificity and in vivo complexity of the mammalian arginylome

    Target site specificity and in vivo complexity of the mammalian arginylome by Wang, Junling, Pejaver, Vikas Rao, Dann, Geoffrey P., Wolf, Maxim Y., Kellis, Manolis, Huang, Yun, Garcia, Benjamin A., Radivojac, Predrag, Kashina, Anna

    Published 2021
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  8. 128
    Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis

    Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis by Yang, Fan, Wang, Jiebiao, The GTEx Consortium, Pierce, Brandon L., Chen, Lin S., Hou, Lei, Kellis, Manolis, Liu, Yaping, Park, YongJin, Rinaldi, Nicola

    Published 2022
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  9. 129
    Analysis of variation at transcription factor binding sites in Drosophila and humans

    Analysis of variation at transcription factor binding sites in Drosophila and humans by Spivakov, Mikhail, Akhtar, Junaid, Kheradpour, Pouya, Beal, Kathryn, Girardot, Charles, Koscielny, Gautier, Herrero, Javier, Kellis, Manolis, Furlong, Eileen E. M., Birney, Ewan

    Published 2012
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  10. 130
    Integrating and mining the chromatin landscape of cell-type specificity using self-organizing maps

    Integrating and mining the chromatin landscape of cell-type specificity using self-organizing maps by Kellis, Manolis, Mortazavi, Ali, Pepke, Shirley, Jansen, Camden, Marinov, Georgi K., Ernst, Jason, Hardison, Ross C., Myers, Richard M., Wold, Barbara J.

    Published 2014
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  11. 131
    Discovery of Human sORF-Encoded Polypeptides (SEPs) in Cell Lines and Tissue

    Discovery of Human sORF-Encoded Polypeptides (SEPs) in Cell Lines and Tissue by Ma, Jiao, Ward, Carl C., Jungreis, Irwin, Slavoff, Sarah A., Schwaid, Adam G., Neveu, John, Budnik, Bogdan A., Kellis, Manolis, Saghatelian, Alan

    Published 2015
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  12. 132
    N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

    N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications by Wang, Yang, Li, Yue, Yue, Minghui, Wang, Jun, Wechsler-Reya, Robert J., Zhang, Zhaolei, Ogawa, Yuya, Kellis, Manolis, Duester, Gregg, Zhao, Jing Crystal

    Published 2020
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  13. 133
    Translation Initiation Site Profiling Reveals Widespread Synthesis of Non-AUG-Initiated Protein Isoforms in Yeast

    Translation Initiation Site Profiling Reveals Widespread Synthesis of Non-AUG-Initiated Protein Isoforms in Yeast by Eisenberg, Amy R, Higdon, Andrea L, Hollerer, Ina, Fields, Alexander P, Jungreis, Irwin, Diamond, Paige D, Kellis, Manolis, Jovanovic, Marko, Brar, Gloria A

    Published 2021
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  14. 134
    Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease

    Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease by Matsushima, Ayano, Pineda, Sergio Sebastian, Crittenden, Jill R, Lee, Hyeseung, Galani, Kyriakitsa, Mantero, Julio, Tombaugh, Geoffrey, Kellis, Manolis, Heiman, Myriam, Graybiel, Ann M

    Published 2023
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  15. 135
    Gamma entrainment using audiovisual stimuli alleviates chemobrain pathology and cognitive impairment induced by chemotherapy in mice

    Gamma entrainment using audiovisual stimuli alleviates chemobrain pathology and cognitive impairment induced by chemotherapy in mice by Kim, TaeHyun, James, Benjamin T., Kahn, Martin C., Blanco-Duque, Cristina, Abdurrob, Fatema, Islam, Md Rezaul, Lavoie, Nicolas S., Kellis, Manolis, Tsai, Li-Huei

    Published 2024
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  16. 136
    Spatial expression of transcription factors in Drosophila embryonic organ development

    Spatial expression of transcription factors in Drosophila embryonic organ development by Hammonds, Ann S., Fisher, William W., Weiszmann, Richard, Wu, Siqi, Hartenstein, Volker, Kellis, Manolis, Yu, Bin, Frise, Erwin, Celniker, Susan E., Bristow, Christopher A.

    Published 2014
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  17. 137
    Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells

    Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells by Jin, Bilian, Ernst, Jason, Tiedemann, Rochelle L., Xu, Hongyan, Sureshchandra, Suhas, Kellis, Manolis, Dalton, Stephen, Liu, Chen, Choi, Jeong-Hyeon, Robertson, Keith D.

    Published 2014
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  18. 138
    Three Periods of Regulatory Innovation During Vertebrate Evolution

    Three Periods of Regulatory Innovation During Vertebrate Evolution by Kellis, Manolis, Lowe, Craig B., Siepel, Adam, Raney, Brian J., Clamp, Michele, Salama, Sofie R., Kingsley, David M., Lindblad-Toh, Kerstin, Haussler, David

    Published 2014
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  19. 139
    MicroRNA and gene expression changes in unruptured human cerebral aneurysms

    MicroRNA and gene expression changes in unruptured human cerebral aneurysms by Bekelis, Kimon, Kerley-Hamilton, Joanna S., Teegarden, Amy, Tomlinson, Craig R., Kuintzle, Rachael, Simmons, Nathan, Singer, Robert J., Roberts, David W., Kellis, Manolis, Hendrix, David

    Published 2017
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  20. 140
    Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors

    Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors by Chen, Di, Sun, Na, Hou, Lei, Kim, Rachel, Faith, Jared, Aslanyan, Marianna, Tao, Yu, Zheng, Yi, Fu, Jianping, Liu, Wanlu, Kellis, Manolis, Clark, Amander

    Published 2021
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