Manolis Kellis
Manolis Kellis (; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.Kellis is known for his contributions to genomics, human genetics, epigenomics, gene regulation, genome evolution, disease mechanism, and single-cell genomics. He co-led the NIH Roadmap Epigenomics Project effort to create a comprehensive map of the human epigenome, the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome, the ENCODE, GENCODE, and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms. A major focus of his work is understanding the effects of genetic variations on human disease, with contributions to obesity, diabetes, Alzheimer's disease, schizophrenia, and cancer. Provided by Wikipedia
Showing 161 - 180 results of 221 for search 'Kellis, Manolis', query time: 0.05s
Refine Results
-
161
Core and region-enriched networks of behaviorally regulated genes and the singing genome by Whitney, Osceola, Pfenning, Andreas R., Howard, Jason T., Blatti, Charles A., Liu, Fang, Ward, James M., Wang, Rui, Audet, Jean-Nicolas, Kellis, Manolis, Mukherjee, Sayan, Sinha, Saurabh, Hartemink, Alexander J., West, Anne E., Jarvis, Erich D.
Published 2016
Get full text
Article -
162
Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation by Lee, Hyeseung, Fenster, Robert J, Pineda, S Sebastian, Gibbs, Whitney S, Mohammadi, Shahin, Davila-Velderrain, Jose, Garcia, Francisco J, Therrien, Martine, Novis, Hailey S, Gao, Fan, Wilkinson, Hilary, Vogt, Thomas, Kellis, Manolis, LaVoie, Matthew J, Heiman, Myriam
Published 2021
Article -
163
A synthetic transcription platform for programmable gene expression in mammalian cells by Chen, William CW, Gaidukov, Leonid, Lai, Yong, Wu, Ming-Ru, Cao, Jicong, Gutbrod, Michael J, Choi, Gigi CG, Utomo, Rachel P, Chen, Ying-Chou, Wroblewska, Liliana, Kellis, Manolis, Zhang, Lin, Weiss, Ron, Lu, Timothy K
Published 2023
Article -
164
A Comprehensive Map of Insulator Elements for the Drosophila Genome by White, Kevin P., Henikoff, Steven, Stein, Lincoln, White, Robert A. H., Russell, Steven, Ahmad, Kami, Feng, Xin, Henikoff, Jorja G., Morrison, Carolyn A., Shah, Parantu K., Brown, Christopher D., Negre, Nicolas, Kheradpour, Pouya, Kellis, Manolis
Published 2010
Article -
165
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes by Madabhushi, Ram, Pfenning, Andreas R., Gao, Fan, Pan, Ling, Yamakawa, Satoko, Seo, Jinsoo, Rueda IV, Richard, Phan, Trongha, Yamakawa, Hidekuni, Pao, Ping-Chieh, Stott, Ryan T, Gjoneska, Elizabeta, Nott, Alexander, Cho, Sukhee, Kellis, Manolis, Tsai, Li-Huei
Published 2017
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text
Article -
166
Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration by Welch, Gwyneth M, Boix, Carles A, Schmauch, Eloi, Davila-Velderrain, Jose, Victor, Matheus B, Dileep, Vishnu, Bozzelli, P Lorenzo, Su, Qiao, Cheng, Jemmie D, Lee, Audrey, Leary, Noelle S, Pfenning, Andreas R, Kellis, Manolis, Tsai, Li-Huei
Published 2023
Article -
167
Long noncoding RNAs regulate adipogenesis by Sun, Lei, Goff, Loyal, Alexander, Ryan K., Lo, Kinyui Alice, Yuan, Bingbing B., Kellis, Manolis, Lodish, Harvey F., Trapnell, Cole, Hacisuleyman, Ezgi, Sauvageau, Martin, Tazon-Vega, Barbara, Kelley, David R., Hendrickson, David G., Rinn, John L.
Published 2013
Get full text
Article -
168
Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells by Ram, Oren, Goren, Alon, Amit, Ido, Shoresh, Noam, Yosef, Nir, Ernst, Jason, Kellis, Manolis, Issner, Robbyn, Durham, Timothy, Zhang, Xiaolan, Donaghey, Julie, Epstein, Charles B., Regev, Aviv, Bernstein, Bradley E., Gymrek, Melissa A., Coyne, Michael J.
Published 2014
Get full text
Get full text
Article -
169
BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair by Hatchi, Elodie, Skourti-Stathaki, Konstantina, Ventz, Steffen, Pinello, Luca, Yen, Angela, Kamieniarz-Gdula, Kinga, Dimitrov, Stoil, Pathania, Shailja, McKinney, Kristine M., Kellis, Manolis, Hill, Sarah J., Parmigiani, Giovanni, Proudfoot, Nicholas J., Livingston, David M., Eaton, Matthew Lucas
Published 2016
Get full text
Get full text
Article -
170
Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome by Shi, Alvin, Kasumova, Gyulnara G, Michaud, William A, Cintolo-Gonzalez, Jessica, Díaz-Martínez, Marta, Ohmura, Jacqueline, Mehta, Arnav, Chien, Isabel, Frederick, Dennie T, Cohen, Sonia, Plana, Deborah, Johnson, Douglas, Flaherty, Keith T, Sullivan, Ryan J, Kellis, Manolis, Boland, Genevieve M
Published 2021
Article -
171
Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome by Shi, Alvin, Kasumova, Gyulnara G, Michaud, William A, Cintolo-Gonzalez, Jessica, Díaz-Martínez, Marta, Ohmura, Jacqueline, Mehta, Arnav, Chien, Isabel, Frederick, Dennie T, Cohen, Sonia, Plana, Deborah, Johnson, Douglas, Flaherty, Keith T, Sullivan, Ryan J, Kellis, Manolis, Boland, Genevieve M
Published 2022
Article -
172
CHD8 Regulates Neurodevelopmental Pathways Associated with Autism Spectrum Disorder in Neural Progenitors by Sugathan, Aarathi, Biagioli, Marta, Golzio, Christelle, Erdin, Serkan, Blumenthal, Ian, Manavalan, Poornima, Ragavendran, Ashok, Brand, Harrison, Lucente, Diane, Miles, Judith, Sheridan, Steven D., Stortchevoi, Alexei, Kellis, Manolis, Haggarty, Stephen J., Katsanis, Nicholas, Gusella, James F., Talkowski, Michael E.
Published 2015
Article -
173
Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes by Blanchard, Joel W, Bula, Michael, Davila-Velderrain, Jose, Akay, Leyla Anne, Zhu, Lena, Frank, Alexander, Victor, Matheus B, Bonner, Julia Maeve, Mathys, Hansruedi, Lin, Yuan-Ta, Ko, Tak, Bennett, David A, Cam, Hugh P, Kellis, Manolis, Tsai, Li-Huei
Published 2021
Article -
174
Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci by Altshuler, Robert Charles, Onuchic, Vitor, Lurie, Eugene, Carrero, Ivenise, Pawliczek, Piotr, Patel, Ronak Y., Rozowsky, Joel, Galeev, Timur, Huang, Zhuoyi, Harris, R. Alan, Coarfa, Cristian, Ashmore, Lillian, Bertol, Jessica W., Fakhouri, Walid D., Yu, Fuli, Kellis, Manolis, Gerstein, Mark, Milosavljevic, Aleksandar
Published 2019
Article -
175
The NF-κB Genomic Landscape in Lymphoblastoid B Cells by Zhao, Bo, Barrera, Luis A., Ersing, Ina, Willox, Bradford, Greenfeld, Hannah, Zhou, Hufeng, Mollo, Sarah B., Shi, Tommy T., Takasaki, Kaoru, Jiang, Sizun, Cahir-McFarland, Ellen, Kellis, Manolis, Bulyk, Martha L., Kieff, Elliott, Gewurz, Benjamin E., Schmidt, Stefanie C. S., Barrera, Luis A.
Published 2016
Get full text
Article -
176
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE by Kheradpour, Pouya, Bristow, Christopher A., Mag Washietl, Stefan, Ay, Ferhat, Jungreis, Irwin, Marbach, Daniel, Sealfon, Rachel Sima, Will, Sebastian, Berger, Bonnie, Kellis, Manolis, Roy, Sushmita, Ernst, Jason, Lin, Michael F., Meyer, Patrick E., Di Stefano, Luisa, Candeias, Rogerio, Nordman, Jared T., Orr-Weaver, Terry L.
Published 2013
Get full text
Get full text
Article -
177
Extensive Variation in Chromatin States Across Humans by Kasowski, Maya, Kyriazopoulou-Panagiotopoulou, Sofia, Grubert, Fabian, Zaugg, Judith B., Kundaje, Anshul, Liu, Yuling, Boyle, Alan P., Zhang, Qiangfeng Cliff, Zakharia, Fouad, Spacek, Damek V., Li, Jingjing, Xie, Dan, Olarerin-George, Anthony, Steinmetz, Lars M., Hogenesch, John B., Kellis, Manolis, Batzoglou, Serafim, Snyder, Michael
Published 2016
Article -
178
Inferring multimodal latent topics from electronic health records by Li, Yue, Nair, Pratheeksha, Lu, Xing Han, Wen, Zhi, Wang, Yuening, Dehaghi, Amir Ardalan Kalantari, Miao, Yan, Liu, Weiqi, Ordog, Tamas, Biernacka, Joanna M, Ryu, Euijung, Olson, Janet E, Frye, Mark A, Liu, Aihua, Guo, Liming, Marelli, Ariane, Ahuja, Yuri, Davila-Velderrain, Jose, Kellis, Manolis
Published 2021
Article -
179
Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity by Wertz, Mary H, Mitchem, Mollie R, Pineda, S Sebastian, Hachigian, Lea J, Lee, Hyeseung, Lau, Vanessa, Powers, Alex, Kulicke, Ruth, Madan, Gurrein K, Colic, Medina, Therrien, Martine, Vernon, Amanda, Beja-Glasser, Victoria F, Hegde, Mudra, Gao, Fan, Kellis, Manolis, Hart, Traver, Doench, John G, Heiman, Myriam
Published 2021
Article -
180
Chromatin Signature Reveals over a Thousand Highly Conserved Large Non-Coding Rnas in Mammals by Guttman, Mitchell, Amit, Ido, Garber, Manuel, French, Courtney, Lin, Michael F., Feldser, David M., Huarte, Maite, Zuk, Or, Carey, Bryce W., Cassady, John P., Cabili, Moran N., Jaenisch, Rudolf, Jacks, Tyler E., Hacohen, Nir, Bernstein, Bradley E., Kellis, Manolis, Lander, Eric S., Mikkelsen, Tarjei Sigurd, 1978-
Published 2010
Get full text
Get full text
Article