Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection by Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier

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Hydroxychloroquine/chloroquine for the treatment of hospitalized patients with COVID-19: An individual participant data meta-analysis. by Leon Di Stefano, Elizabeth L Ogburn, Malathi Ram, Daniel O Scharfstein, Tianjing Li, Preeti Khanal, Sheriza N Baksh, Nichol McBee, Joshua Gruber, Marianne R Gildea, Megan R Clark, Neil A Goldenberg, Yussef Bennani, Samuel M Brown, Whitney R Buckel, Meredith E Clement, Mark J Mulligan, Jane A O'Halloran, Adriana M Rauseo, Wesley H Self, Matthew W Semler, Todd Seto, Jason E Stout, Robert J Ulrich, Jennifer Victory, Barbara E Bierer, Daniel F Hanley, Daniel Freilich, Pandemic Response COVID-19 Research Collaboration Platform for HCQ/CQ Pooled Analyses

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Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections by Christopher JR Illingworth, William L Hamilton, Ben Warne, Matthew Routledge, Ashley Popay, Chris Jackson, Tom Fieldman, Luke W Meredith, Charlotte J Houldcroft, Myra Hosmillo, Aminu S Jahun, Laura G Caller, Sarah L Caddy, Anna Yakovleva, Grant Hall, Fahad A Khokhar, Theresa Feltwell, Malte L Pinckert, Iliana Georgana, Yasmin Chaudhry, Martin D Curran, Surendra Parmar, Dominic Sparkes, Lucy Rivett, Nick K Jones, Sushmita Sridhar, Sally Forrest, Tom Dymond, Kayleigh Grainger, Chris Workman, Mark Ferris, Effrossyni Gkrania-Klotsas, Nicholas M Brown, Michael P Weekes, Stephen Baker, Sharon J Peacock, Ian G Goodfellow, Theodore Gouliouris, Daniela de Angelis, M Estée Török

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Research on the Epidemiology of SARS-CoV-2 in Essential Response Personnel (RECOVER): Protocol for a Multisite Longitudinal Cohort Study by Laura J Edwards, Ashley L Fowlkes, Meredith G Wesley, Jennifer L Kuntz, Marilyn J Odean, Alberto J Caban-Martinez, Kayan Dunnigan, Andrew L Phillips, Lauren Grant, Meghan K Herring, Holly C Groom, Karley Respet, Shawn Beitel, Tnelda Zunie, Kurt T Hegmann, Archana Kumar, Gregory Joseph, Brandon Poe, Paola Louzado-Feliciano, Michael E Smith, Matthew S Thiese, Natasha Schaefer-Solle, Young M Yoo, Carlos A Silvera, Julie Mayo Lamberte, Josephine Mak, L Clifford McDonald, Matthew J Stuckey, Preeta Kutty, Melissa L Arvay, Sarang K Yoon, Harmony L Tyner, Jefferey L Burgess, Danielle Rentz Hunt, Jennifer Meece, Manjusha Gaglani, Allison L Naleway, Mark G Thompson

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Genomic epidemiology of COVID-19 in care homes in the east of England by William L Hamilton, Gerry Tonkin-Hill, Emily R Smith, Dinesh Aggarwal, Charlotte J Houldcroft, Ben Warne, Luke W Meredith, Myra Hosmillo, Aminu S Jahun, Martin D Curran, Surendra Parmar, Laura G Caller, Sarah L Caddy, Fahad A Khokhar, Anna Yakovleva, Grant Hall, Theresa Feltwell, Malte L Pinckert, Iliana Georgana, Yasmin Chaudhry, Colin S Brown, Sonia Gonçalves, Roberto Amato, Ewan M Harrison, Nicholas M Brown, Mathew A Beale, Michael Spencer Chapman, David K Jackson, Ian Johnston, Alex Alderton, John Sillitoe, Cordelia Langford, Gordon Dougan, Sharon J Peacock, Dominic P Kwiatowski, Ian G Goodfellow, M Estee Torok, COVID-19 Genomics Consortium UK

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Southern ocean carbon and heat impact on climate by Sallée, JB, Abrahamsen, EP, Allaigre, C, Auger, M, Ayres, H, Badhe, R, Boutin, J, Brearley, JA, de Lavergne, C, Ten Doeschate, AMM, Droste, ES, du Plessis, MD, Ferreira, D, Giddy, IS, Gülk, B, Gruber, N, Hague, M, Hoppema, M, Josey, SA, Kanzow, T, Kimmritz, M, Lindeman, MR, Llanillo, PJ, Lucas, NS, Madec, G, Marshall, DP, Meijers, AJS, Meredith, MP, Mohrmann, M, Monteiro, PMS, Mosneron Dupin, C, Naeck, K, Narayanan, A, Naveira Garabato, AC, Nicholson, S-A, Novellino, A, Ödalen, M, Østerhus, S, Park, W, Patmore, RD, Piedagnel, E, Roquet, F, Rosenthal, HS, Roy, T, Saurabh, R, Silvy, Y, Spira, T, Steiger, N, Styles, AF

Using electronic health records to enhance surveillance of diabetes in children, adolescents and young adults: a study protocol for the DiCAYA Network by Hui Zhou, Manmohan Kamboj, Yi Guo, Angela D Liese, Rebecca Anthopolos, Lu Zhang, John Chang, Anna Roberts, Tessa Crume, Brian E Dixon, Hui Shao, David C Lee, Lorna E Thorpe, Dimitri Christakis, Eneida A Mendonca, Katie Allen, Dana Dabelea, Giuseppina Imperatore, Mark Weiner, Meredith Akerman, Rong Wei, Kristi Reynolds, Annemarie G Hirsch, Jasmin Divers, Tianchen Lyu, Alex Ewing, Shaun Grannis, Yuan Luo, Bo Cai, Anthony Wong, Brian S Schwartz, Meda Pavkov, Meredith Lewis, Sarah Conderino, Jiang Bian, Yonghui Wu, Jihad S Obeid, Harold P Lehmann, Charles Bailey, Theresa Anderson, Elizabeth A Shenkman, Elizabeth Nauman, Christopher Forrest, Mattia Prosperi, Seho Park, Cara M Nordberg, Tessa L Crume, Anna Bellatorre, Stefanie Bendik, Marc Rosenman, Levon Utidjian, Mitch Maltenfort, Amy Shah, G Todd Alonso, Sara Deakyne-Davies, Tim Bunnell, Anne Kazak, Melody Kitzmiller, Daksha Ranade, Joseph J DeWalle, H Lester Kirchner, Dione G Mercer, Amy Poissant, Nimish Valvi, Jeff Warvel, Ashley Wiensch, Tamara Hannon, Eva Lustigova, Don McCarthy, Matthew T Mefford, George Lales, Allison Zelinski, Pedro Rivera, Thomas Carton, Victor W Zhong, Andrew Fair, Jessica Guillaume, Shahidul Islam, Alan Jacobson, Chinyere Okpara, Anand Rajan, Andrea Titus, Rebecca Conway, Toan Ong, Jack Pattee, Shawna Burgett, Bethlehem Shiferaw, Sarah J Bost, William T Donahoo, William R Hogan, Piaopiao Li, Lisa Knight, Caroline Rudisill, Jessica Stucker, Deborah Bowlby, Elaine Apperson, Deborah B Rolka

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Patterns of within-host genetic diversity in SARS-CoV-2 by Gerry Tonkin-Hill, Inigo Martincorena, Roberto Amato, Andrew RJ Lawson, Moritz Gerstung, Ian Johnston, David K Jackson, Naomi Park, Stefanie V Lensing, Michael A Quail, Sónia Gonçalves, Cristina Ariani, Michael Spencer Chapman, William L Hamilton, Luke W Meredith, Grant Hall, Aminu S Jahun, Yasmin Chaudhry, Myra Hosmillo, Malte L Pinckert, Iliana Georgana, Anna Yakovleva, Laura G Caller, Sarah L Caddy, Theresa Feltwell, Fahad A Khokhar, Charlotte J Houldcroft, Martin D Curran, Surendra Parmar, The COVID-19 Genomics UK (COG-UK) Consortium, Alex Alderton, Rachel Nelson, Ewan M Harrison, John Sillitoe, Stephen D Bentley, Jeffrey C Barrett, M Estee Torok, Ian G Goodfellow, Cordelia Langford, Dominic Kwiatkowski, Wellcome Sanger Institute COVID-19 Surveillance Team

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Risk Factors for Reinfection with SARS-CoV-2 Omicron Variant among Previously Infected Frontline Workers by Katherine D. Ellingson, James Hollister, Cynthia J. Porter, Sana M. Khan, Leora R. Feldstein, Allison L. Naleway, Manjusha Gaglani, Alberto J. Caban-Martinez, Harmony L. Tyner, Ashley A. Lowe, Lauren E.W. Olsho, Jennifer Meece, Sarang K. Yoon, Josephine Mak, Jennifer L. Kuntz, Natasha Schaefer Solle, Karley Respet, Zoe Baccam, Meredith G. Wesley, Matthew S. Thiese, Young M. Yoo, Marilyn J. Odean, Flavia N. Miiro, Steve L. Pickett, Andrew L. Phillips, Lauren Grant, James K. Romine, Meghan K. Herring, Kurt T. Hegmann, Julie Mayo Lamberte, Brian Sokol, Krystal S. Jovel, Mark G. Thompson, Patrick Rivers, Tamara Pilishvili, Karen Lutrick, Jefferey L. Burgess, Claire M. Midgley, Ashley L. Fowlkes

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Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa by Weiyin Zhou, Anja Fischer, Martin D. Ogwang, Wen Luo, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Mateus H. Gouveia, Nathan Cole, Belynda Hicks, Kristine Jones, Michael Hummel, Mathias Schlesner, George Chagaluka, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Selina Glaser, Helene Kretzmer, Michelle Manning, Amy Hutchinson, Ann W. Hsing, Yao Tettey, Andrew A. Adjei, Stephen J. Chanock, Reiner Siebert, Meredith Yeager, Ludmila Prokunina-Olsson, Mitchell J. Machiela, Sam M. Mbulaiteye

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A Uniform Analysis of Debris Disks with the Gemini Planet Imager. I. An Empirical Search for Perturbations from Planetary Companions in Polarized Light Images by Katie A. Crotts, Brenda C. Matthews, Gaspard Duchêne, Thomas M. Esposito, Ruobing Dong, Justin Hom, Rebecca Oppenheimer, Malena Rice, Schuyler G. Wolff, Christine H. Chen, Clarissa R. Do Ó, Paul Kalas, Briley L. Lewis, Alycia J. Weinberger, David J. Wilner, Mark Ammons, Pauline Arriaga, Robert J. De Rosa, John H. Debes, Michael P. Fitzgerald, Eileen C. Gonzales, Dean C. Hines, Sasha Hinkley, A. Meredith Hughes, Ludmilla Kolokolova, Eve J. Lee, Ronald A. López, Bruce Macintosh, Johan Mazoyer, Stanimir Metchev, Maxwell A. Millar-Blanchaer, Eric L. Nielsen, Jenny Patience, Marshall D. Perrin, Laurent Pueyo, Fredrik T. Rantakyrö, Bin B. Ren, Glenn Schneider, Remi Soummer, Christopher C. Stark

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Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report by Buckland, MS, Galloway, JB, Fhogartaigh, CN, Meredith, L, Provine, NM, Bloor, S, Ogbe, A, Zelek, WM, Smielewska, A, Yakovleva, A, Mann, T, Bergamaschi, L, Turner, L, Mescia, F, Toonen, EJM, Hackstein, C-P, Akther, HD, Vieira, VA, Ceron-Gutierrez, L, Periselneris, J, Kiani-Alikhan, S, Grigoriadou, S, Vaghela, D, Lear, SE, Török, ME, Hamilton, WL, Stockton, J, Quick, J, Nelson, P, Hunter, M, Coulter, TI, Devlin, L, CITIID-NIHR COVID-19 BioResource Collaboration, MRC-Toxicology Unit COVID-19 Consortium, Bradley, JR, Smith, KGC, Ouwehand, WH, Estcourt, L, Harvala, H, Roberts, DJ, Wilkinson, IB, Screaton, N, Loman, N, Doffinger, R, Lyons, PA, Morgan, BP, Goodfellow, IG, Klenerman, P, Lehner, PJ, Matheson, NJ

Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma by Zhiwei Liu, Yang Luo, Samuel Kirimunda, Murielle Verboom, Olusegun O. Onabajo, Mateus H. Gouveia, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Herry Dhudha, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Nathan Cole, Wen Luo, Jia Liu, Michelle Manning, Belynda Hicks, Ludmila Prokunina-Olsson, George Chagaluka, W. Thomas Johnston, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Ann W. Hsing, James E. Mensah, Anthony A. Adjei, Amy Hutchinson, Mary Carrington, Meredith Yeager, Rainer Blasczyk, Stephen J. Chanock, Soumya Raychaudhuri, Sam M. Mbulaiteye

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Cardiac outcomes of subjects on adjuvant trastuzumab emtansine vs paclitaxel in combination with trastuzumab for stage I HER2-positive breast cancer (ATEMPT) study (TBCRC033): a ra... by Romualdo Barroso-Sousa, Paolo Tarantino, Nabihah Tayob, Chau Dang, Denise A. Yardley, Steven J. Isakoff, Vicente Valero, Meredith Faggen, Therese Mulvey, Ron Bose, Jiani Hu, Douglas Weckstein, Antonio C. Wolff, Katherine Reeder-Hayes, Hope S. Rugo, Bhuvaneswari Ramaswamy, Dan Zuckerman, Lowell Hart, Vijayakrishna K. Gadi, Michael Constantine, Kit Cheng, Frederick Briccetti, Bryan Schneider, Audrey Merrill Garrett, Kelly Marcom, Kathy Albain, Patricia DeFusco, Nadine Tung, Blair Ardman, Rita Nanda, Rachel C. Jankowitz, Mothaffar Rimawi, Vandana Abramson, Paula R. Pohlmann, Catherine Van Poznak, Andres Forero-Torres, Minetta Liu, Kathryn J. Ruddy, Yue Zheng, Shoshana M. Rosenberg, Richard D. Gelber, Lorenzo Trippa, William Barry, Michelle DeMeo, Harold Burstein, Ann Partridge, Eric P. Winer, Ian Krop, Sara M. Tolaney

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Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases by Arias, A, Watson, S, Asogun, D, Tobin, E, Lu, J, Phan, M, Jah, U, Wadoum, R, Meredith, L, Thorne, L, Caddy, S, Tarawalie, A, Langat, P, Dudas, G, Faria, N, Dellicour, S, Kamara, A, Kargbo, B, Kamara, B, Gevao, S, Cooper, D, Newport, M, Horby, P, Dunning, J, Sahr, F, Brooks, T, Simpson, A, Groppelli, E, Liu, G, Mulakken, N, Rhodes, K, Akpablie, J, Yoti, Z, Lamunu, M, Vitto, E, Otim, P, Owilli, C, Boateng, I, Okoror, L, Omomoh, E, Oyakhilome, J, Omiunu, R, Yemisis, I, Adomeh, D, Ehikhiametalor, S, Akhilomen, P, Aire, C, Kurth, A, Cook, N, Baumann, J, Gabriel, M, Wölfel, R, Di Caro, A, Carroll, M, Günther, S, Redd, J, Naidoo, D, Pybus, O, Rambaut, A, Kellam, P, Goodfellow, I, Cotten, M

Splicing profile by capture RNA-seq identifies pathogenic germline variants in tumor suppressor genes by Tyler Landrith, Bing Li, Ashley A. Cass, Blair R. Conner, Holly LaDuca, Danielle B. McKenna, Kara N. Maxwell, Susan Domchek, Nichole A. Morman, Christopher Heinlen, Deborah Wham, Cathryn Koptiuch, Jennie Vagher, Ragene Rivera, Ann Bunnell, Gayle Patel, Jennifer L. Geurts, Morgan M. Depas, Shraddha Gaonkar, Sara Pirzadeh-Miller, Rebekah Krukenberg, Meredith Seidel, Robert Pilarski, Meagan Farmer, Khateriaa Pyrtel, Kara Milliron, John Lee, Elizabeth Hoodfar, Deepika Nathan, Amanda C. Ganzak, Sitao Wu, Huy Vuong, Dong Xu, Aarani Arulmoli, Melissa Parra, Lily Hoang, Bhuvan Molparia, Michele Fennessy, Susanne Fox, Sinead Charpentier, Julia Burdette, Tina Pesaran, Jessica Profato, Brandon Smith, Ginger Haynes, Emily Dalton, Joy Rae-Radecki Crandall, Ruth Baxter, Hsiao-Mei Lu, Brigette Tippin-Davis, Aaron Elliott, Elizabeth Chao, Rachid Karam

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Author Correction: CD98hc is a target for brain delivery of biotherapeutics by Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis

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CD98hc is a target for brain delivery of biotherapeutics by Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis

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Pediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT): Protocol for a Multisite Longitudinal Cohort Study by Joy Burns, Patrick Rivers, Lindsay B LeClair, Krystal S Jovel, Ramona P Rai, Ashley A Lowe, Laura J Edwards, Sana M Khan, Clare Mathenge, Maria Ferraris, Jennifer L Kuntz, Julie Mayo Lamberte, Kurt T Hegmann, Marilyn J Odean, Hilary McLeland-Wieser, Shawn Beitel, Leah Odame-Bamfo, Natasha Schaefer Solle, Josephine Mak, Andrew L Phillips, Brian E Sokol, James Hollister, Jezahel S Ochoa, Lauren Grant, Matthew S Thiese, Keya B Jacoby, Karen Lutrick, Felipe A Pubillones, Young M Yoo, Danielle Rentz Hunt, Katherine Ellingson, Mark C Berry, Joe K Gerald, Joanna Lopez, Lynn B Gerald, Meredith G Wesley, Karl Krupp, Meghan K Herring, Purnima Madhivanan, Alberto J Caban-Martinez, Harmony L Tyner, Jennifer K Meece, Sarang K Yoon, Ashley L Fowlkes, Allison L Naleway, Lisa Gwynn, Jefferey L Burgess, Mark G Thompson, Lauren EW Olsho, Manjusha Gaglani

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Safety and efficacy of HSP90 inhibitor ganetespib for neoadjuvant treatment of stage II/III breast cancer by Julie E. Lang, Andres Forero-Torres, Douglas Yee, Christina Yau, Denise Wolf, John Park, Barbara A. Parker, A. Jo Chien, Anne M. Wallace, Rashmi Murthy, Kathy S. Albain, Erin D. Ellis, Heather Beckwith, Barbara B. Haley, Anthony D. Elias, Judy C. Boughey, Rachel L. Yung, Claudine Isaacs, Amy S. Clark, Hyo S. Han, Rita Nanda, Qamar J. Khan, Kristen K. Edmiston, Erica Stringer-Reasor, Elissa Price, Bonnie Joe, Minetta C. Liu, Lamorna Brown-Swigart, Emanuel F. Petricoin, Julia D. Wulfkuhle, Meredith Buxton, Julia L. Clennell, Ashish Sanil, Scott Berry, Smita M. Asare, Amy Wilson, Gillian L. Hirst, Ruby Singhrao, Adam L. Asare, Jeffrey B. Matthews, Michelle Melisko, Jane Perlmutter, Hope S. Rugo, W. Fraser Symmans, Laura J. van ‘t Veer, Nola M. Hylton, Angela M. DeMichele, Donald A. Berry, Laura J. Esserman

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