Advancing CART therapy for acute myeloid leukemia: recent breakthroughs and strategies for future development by Lorena Pérez-Amill, Lorena Pérez-Amill, Lorena Pérez-Amill, Àlex Bataller, Àlex Bataller, Julio Delgado, Julio Delgado, Julio Delgado, Jordi Esteve, Jordi Esteve, Jordi Esteve, Manel Juan, Manel Juan, Manel Juan, Manel Juan, Nela Klein-González, Nela Klein-González, Nela Klein-González

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P743: CLINICAL OUTCOMES OF PATIENTS WITH MYELODYSPLASTIC SYNDROME AND SPLICEOSOME MUTATIONS by Samuel Urrutia, Emmanuel Almanza, Alex Bataller, Koji Sasaki, Kelly Chien, Rashmi Kanagal-Shamanna, Guillermo Montalban-Bravo, Carlos Bueso-Ramos, Sherry Pierce, Hagop Kantarjian, Guillermo Garcia-Manero

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P532: KINETICS AND PROGNOSTIC VALUE OF MEASURABLE RESIDUAL DISEASE (MRD) IN PATIENTS DIAGNOSED WITH ACUTE MYELOID LEUKEMIA (AML) TREATED WITH VENETOCLAX IN COMBINATION WITH HYPOMET... by Carlos Jimenez-Vicente, Francesca Guijarro, Monica Lopez-Guerra, Ares Guardia-Torrelles, Alexandra Martínez Roca, Alex Bataller, Daniel Esteban, Albert Cortés, Inés Zugasti, Daniel Munarriz, Dolors Colomer, Marina Diaz-Beya, Jordi Esteve

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Myeloid lineage switch in <i>KMT2A-</i>rearranged acute lymphoblastic leukemia treated with lymphoid lineagedirected therapies by Alex Bataller, Tareq Abuasab, David McCall, Wei Wang, Branko Cuglievan, Ghayas C. Issa, Elias Jabbour, Nicholas Short, Courtney D. DiNardo, Guilin Tang, Guillermo Garcia-Manero, Hagop M. Kantarjian, Koji Sasaki

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PB1846: MANAGEMENT OF PATIENTS TREATED WITH VENETOCLAX WITH HYPOMETHYLATING AGENTS: LONG-TERM INCIDENCE OF CYTOPENIAS AND INFECTIONS by Ares Guardia-Torrelles, Carlos Jimenez-Vicente, Alexandra Martínez Roca, Sandra Castaño-Díez, Helena Brillembourg, Francesca Guijarro, Àlex Bataller, Daniel Esteban, Albert Cortés, Inés Zugasti, Daniel Munarriz, Marina Diaz-Beya, Jordi Esteve, Beatriz Merchan

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P728: EVALUATION OF IPSS-M IN PATIENTS WITH MYELODYSPLASTIC SYNDROME AND SPLICEOSOME MUTATIONS by Samuel Urrutia, Ziyi LI, Emmanuel Almanza, Alex Bataller, Rashmi Kanagal-Shamanna, Jayastu Senapati, Koji Sasaki, Kelly Chien, Guillermo Montalban-Bravo, Courtney Dinardo, Gautam Borthakur, Carlos Bueso Ramos, Sherry Pierce, Hagop Kantarjian, Guillermo Garcia-Manero

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P500: SUPERIOR OUTCOMES AFTER ALLOGENEIC STEM CELL TRANSPLANTATION AMONG PATIENTS ≥ 60 YEARS TREATED WITH CLADRIBINE, LOW DOSE CYTARABINE PLUS VENETOCLAX FOR NEWLY DIAGNOSED ACUTE... by Jayastu Senapati, Hagop Kantarjian, Alexandre Bazinet, Patrick Reville, Gautam Borthakur, Naval Daver, Courtney Dinardo, Alex Bataller, Elias Jabbour, Nicholas Short, Uday R. Popat, Amin Majid Alousi, Elizabeth J. Shpall, Guillermo Garcia-Manero, Farhad Ravandi, Tapan Kadia

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Serum monoclonal component in chronic lymphocytic leukemia: baseline correlations and prognostic impact by Pablo Mozas, Juan A. Pineyroa, Ferran Nadeu, Laura Magnano, Andrea Rivero, Alfredo Rivas-Delgado, Alex Bataller, Aleix Fabregat, Eva Gine, Tycho Baumann, Neus Villamor, Juan Ignacio Arostegui, Marta Aymerich, Armando Lopez-Guillermo, Elias Campo, Julio Delgado

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Long-Term Responders After Autologous Stem Cell Transplantation in Multiple Myeloma by Aina Oliver-Caldes, Aina Oliver-Caldes, Juan Carlos Soler-Perromat, Ester Lozano, Ester Lozano, David Moreno, David Moreno, Alex Bataller, Alex Bataller, Pablo Mozas, Pablo Mozas, Marta Garrote, Xavier Setoain, Juan Ignacio Aróstegui, Jordi Yagüe, Natalia Tovar, Natalia Tovar, Raquel Jiménez, Raquel Jiménez, Luis Gerardo Rodríguez-Lobato, Luis Gerardo Rodríguez-Lobato, M. Teresa Cibeira, M. Teresa Cibeira, Laura Rosiñol, Laura Rosiñol, Joan Bladé, Joan Bladé, Manel Juan, Manel Juan, Carlos Fernández de Larrea, Carlos Fernández de Larrea

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S172: PHASE 1/2 STUDY OF ORAL DECITABINE/CEDAZURIDINE IN COMBINATION WITH VENETOCLAX IN TREATMENT-NAÏVE HIGHER-RISK MYELODYSPLASTIC SYNDROMES OR CHRONIC MYELOMONOCYTIC LEUKEMIA by Alex Bataller, Alexandre Bazinet, Sangeetha Venugopal, Guillermo Montalban-Bravo, Yesid Alvarado, Kelly Chien, Ghayas Issa, Nicholas Short, Danielle Hammond, Lucia Masarova, Tapan Kadia, Rashmi Kanagal-Shamanna, Stephany Hendrickson, Farhad Ravandi, Elias Jabbour, Hagop Kantarjian, Guillermo Garcia-Manero

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P748: IPSS-M PERFORMANCE IN PATIENTS WITH MYELODYSPLASTIC SYNDROME AT THE TIME OF HYPOMETHYLATING AGENT FAILURE by Samuel Urrutia, Kelly Chien, Ziyi LI, Alex Bataller, Emmanuel Almanza, Koji Sasaki, Guillermo Montalban-Bravo, Nicholas Short, Elias Jabbour, Tapan Kadia, Farhad Ravandi, Gautam Borthakur, Rashmi Kanagal-Shamanna, Carlos Bueso Ramos, Sherry Pierce, Hagop Kantarjian, Guillermo Garcia-Manero

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P730: EVOLUTION OF IPSS-M RISK CATEGORIES IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES FROM DIAGNOSIS TO HYPOMETHYLATING AGENT FAILURE by Kelly Chien, Samuel Urrutia, Ziyi LI, Rashmi Kanagal-Shamanna, Emmanuel Almanza, Tareq Abuasab, Georgina Gener, Alex Bataller, Alexandre Bazinet, Guillermo Montalban-Bravo, Nicholas Short, Elias Jabbour, Tapan Kadia, Farhad Ravandi, Gautam Borthakur, Danielle Hammond, Mahesh Swaminathan, Koji Sasaki, Sherry Pierce, Hagop Kantarjian, Guillermo Garcia-Manero

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Impact of measurable residual disease clearance kinetics in patients with AML undergoing intensive chemotherapy by Wei-Ying Jen, Koji Sasaki, Farhad Ravandi, Tapan M. Kadia, Sa A. Wang, Wei Wang, Sanam Loghavi, Naval G. Daver, Courtney D. DiNardo, Ghayas C. Issa, Hussein A. Abbas, Cedric Nasnas, Alex Bataller, Samuel Urrutia, Omer S. Karrar, Sherry Pierce, Hagop M. Kantarjian, Nicholas J. Short

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Survival improvement of patients with FLT3 mutated acute myeloid leukemia: results from a prospective 9 years cohort by Guadalupe Oñate, Marta Pratcorona, Ana Garrido, Alicia Artigas-Baleri, Alex Bataller, Mar Tormo, Montserrat Arnan, Susana Vives, Rosa Coll, Olga Salamero, Ferran Vall-Llovera, Antònia Sampol, Antoni Garcia, Marta Cervera, Sara Garcia Avila, Joan Bargay, Xavier Ortín, Josep F. Nomdedéu, Jordi Esteve, Jorge Sierra, Spanish Cooperative Group for the Study and Treatment of Acute Leukemias and Myelodysplasias (CETLAM)

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Outcomes and genetic dynamics of acute myeloid leukemia at first relapse by Alex Bataller, Hagop Kantarjian, Alexandre Bazinet, Tapan Kadia, Naval Daver, Courtney D. DiNardo, Gautam Borthakur, Sanam Loghavi, Keyur Patel, Guilin Tang, Koji Sasaki, Nicholas J. Short, Musa Yilmaz, Ghayas C. Issa, Yesid Alvarado, Guillermo Montalban-Bravo, Abhishek Maiti, Hussein A. Abbas, Koichi Takahashi, Sherry Pierce, Elias Jabbour, Guillermo Garcia-Manero, Farhad Ravandi

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41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo by Pablo Menendez, Maria Castella, Pedro Marín, Alex Bataller, Jordi Esteve, Diego Sánchez Martínez, Francisco Gutiérrez Agüera, Heleia Roca Ho, Clara Bueno, Matteo Libero Baroni, Talia Velasco Hernandez, Rafael Diaz de la Guardia, Julio Castaño, Eduardo Anguita, Susana Vives, Josep Nomdedeu, Helene Lapillone, Anne E Bras, Vincent H J van der Velden, Jordi Junca, Binje Vick, Irmela Jeremias, Angel Lopez, Marc Sorigue

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Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high‐hyperdiploid B‐cell acute lymphoblastic leukemia by Mireia Ramos‐Muntada, Juan L. Trincado, Joan Blanco, Clara Bueno, Virginia C. Rodríguez‐Cortez, Alex Bataller, Belén López‐Millán, Claire Schwab, Margarita Ortega, Pablo Velasco, Maria L. Blanco, Josep Nomdedeu, Manuel Ramírez‐Orellana, Alfredo Minguela, Jose L. Fuster, Esther Cuatrecasas, Mireia Camós, Paola Ballerini, Gabriele Escherich, Judith Boer, Monique DenBoer, Jesús M. Hernández‐Rivas, Maria J. Calasanz, Giovanni Cazzaniga, Christine J. Harrison, Pablo Menéndez, Oscar Molina

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P1356: CD84-TARGETED CART-CELL THERAPY: A NOVEL STRATEGY FOR THE TREATMENT OF HAEMATOLOGICAL MALIGNANCIES by Lorenza Pérez Amill, Mercedes Armand Ugon, Sergio Peña Pérez, Maria Val Casals, Claudio Santos, Gerard Frigola, José Ramon Álamo, Francesca Guijarro, Alfredo Minguela, Àlex Bataller, Juan Gonzalo Correa Saldarriaga, Berta Casanovas Albertí, Mireia Uribe Herranz, Europa Azucena Gonzalez, Daniel Benitez-Ribas, Diego Sanchez, Nestor Tirado, Paola Romecin, Talía Velasco, Pablo Menendez, Antonio Martínez, Montserrat Rovira Tarrats, Jordi Esteve, Avaro Urbano Ispizua, Julio Delgado, Manel Juan, Nela Klein González

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Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells by Talia Velasco‐Hernandez, Juan L. Trincado, Meritxell Vinyoles, Adria Closa, Alba Martínez‐Moreno, Francisco Gutiérrez‐Agüera, Oscar Molina, Virginia C. Rodríguez‐Cortez, Pau Ximeno‐Parpal, Narcís Fernández‐Fuentes, Paolo Petazzi, Sergi Beneyto‐Calabuig, Lars Velten, Paola Romecin, Raquel Casquero, Fernando Abollo‐Jiménez, Rafael D. de laGuardia, Patricia Lorden, Alex Bataller, Hélène Lapillonne, Ronald W. Stam, Susana Vives, Montserrat Torrebadell, Jose L. Fuster, Clara Bueno, Jean‐Emmanuel Sarry, Eduardo Eyras, Holger Heyn, Pablo Menéndez

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