Parkinson disease, LRRK2 and the endocytic-autophagic pathway. Por Alegre-Abarrategui, J, Wade-Martins, R

RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum. Por Thomas, M, Alegre-Abarrategui, J, Wade-Martins, R

Alpha-synuclein proximity ligation assay (AS-PLA) in brain sections to probe for alpha-synuclein oligomers Por Roberts, RF, Bengoa-Vergniory, N, Alegre-Abarrategui, J

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models. Por Sloan, M, Alegre-Abarrategui, J, Wade-Martins, R

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease. Por Alegre-Abarrategui, J, Ansorge, O, Esiri, M, Wade-Martins, R

A Novel Genomic DNA-Reporter Gene Model for the Study of Friedreich's Ataxia in Neuronal Cells Por Lufino, M, Alegre-Abarrategui, J, Lim, F, Wade-Martins, R

Alpha-synuclein oligomers: a new hope. Por Bengoa-Vergniory, N, Roberts, R, Wade-Martins, R, Alegre-Abarrategui, J

A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds. Por Lufino, M, Silva, A, Németh, A, Alegre-Abarrategui, J, Russell, A, Wade-Martins, R

Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease Por Ruffmann, C, Bengoa-Vergniory, N, Poggiolini, I, Ritchie, D, Hu, M, Alegre-Abarrategui, J, Parkkinen, L

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Por Alegre-Abarrategui, J, Christian, H, Lufino, M, Mutihac, R, Venda, L, Ansorge, O, Wade-Martins, R

TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons. Por Mutihac, R, Alegre-Abarrategui, J, Gordon, D, Farrimond, L, Yamasaki-Mann, M, Talbot, K, Wade-Martins, R

Selective vulnerability in α-synucleinopathies. Por Alegre-Abarrategui, J, Brimblecombe, K, Roberts, R, Velentza-Almpani, E, Tilley, B, Bengoa-Vergniory, N, Proukakis, C

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders Por Agarwal, D, Sandor, C, Volpato, V, Caffrey, TM, Monzón-Sandoval, J, Bowden, R, Alegre-Abarrategui, J, Wade-Martins, R, Webber, C

A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells. Por Phadwal, K, Alegre-Abarrategui, J, Watson, A, Pike, L, Anbalagan, S, Hammond, E, Wade-Martins, R, McMichael, A, Klenerman, P, Simon, A

Impairment of macroautophagy in dopamine neurons has opposing effects on parkinsonian pathology and behaviour Por Hunn, B, Vingill, S, Threlfell, S, Alegre-Abarrategui, J, Magdelyns, M, Deltheil, T, Bengoa-Vergniory, N, Oliver, P, Cioroch, M, Doig, N, Bannerman, D, Cragg, S, Wade-Martins, R

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells Por Smith, A, Depp, C, Ryan, B, Johnston, G, Alegre-Abarrategui, J, Evetts, S, Rolinski, M, Baig, F, Ruffmann, C, Simon, A, Hu, M, Wade-Martins, R

Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysf... Por Gordon, D, Dafinca, R, Scaber, J, Alegre-Abarrategui, J, Farrimond, L, Scott, C, Biggs, D, Kent, L, Oliver, P, Davies, B, Ansorge, O, Wade-Martins, R, Talbot, K

LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function. Por Sloan, M, Alegre-Abarrategui, J, Potgieter, D, Kaufmann, A, Exley, R, Deltheil, T, Threlfell, S, Connor-Robson, N, Brimblecombe, K, Wallings, R, Cioroch, M, Bannerman, D, Bolam, J, Magill, P, Cragg, S, Dodson, P, Wade-Martins, R

On the diagnosis of CADASIL. Por Ampuero, I, Alegre-Abarrategui, J, Rodal, I, España, A, Ros, R, Sendón, J, Galloway, E, Cervelló, A, Caminero, AB, Zabala, A, Erro, E, Jarauta, F, Morlán, L, López-Valdés, E, Aladro, Y, Seijo, M, Rivas, G, Muñoz, D, de Yébenes, J

The role of alpha-synuclein oligomers in Parkinson's disease pathophysiology and biology Por Roberts, R

Outros Autores: “...Abarrategui, J...”