Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma by Leonard E. Estephan, Gaurav Kumar, Gaurav Kumar, Matthew Stewart, Matthew Stewart, Raphael Banoub, Alban Linnenbach, Alban Linnenbach, Larry A. Harshyne, Larry A. Harshyne, Ubaldo E. Martinez-Outschoorn, Ubaldo E. Martinez-Outschoorn, My G. Mahoney, My G. Mahoney, Joseph M. Curry, Joseph M. Curry, Jennifer Johnson, Jennifer Johnson, Jennifer Johnson, Andrew P. South, Andrew P. South, Adam J. Luginbuhl, Adam J. Luginbuhl

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555 Challenges in predicting ICI response in HPV+ HNSCC: insights into the tumor microenvironment by Nathan Fowler, Nikita Kotlov, Adam J Luginbuhl, Vladimir Kushnarev, Anna Love, Alexander Bagaev, Joseph M Curry, Alban J Linnenbach, Anastasia Sobol, Evgeniia Alekseeva, Andrey Tyshevich, Christopher JH Davitt, Anastasiia Nikitina

Nivolumab and ipilimumab in combination with radiotherapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck by Madalina Tuluc, Ioannis A Vathiotis, Joseph Curry, Jennifer M Johnson, Ayesha Ali, Larry A Harshyne, Voichita Bar Ad, Rita Axelrod, Emily Lorber, David M Cognetti, Adam J Luginbuhl, Scott Keith, Mỹ G Mahoney, Athanassios Argiris

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629-B Window of opportunity for durvalumab plus metformin trial in head & neck squamous cell carcinoma (HNSCC) by Madalina Tuluc, Jennifer Johnson, Derek Mann, Ubaldo Martinez-Outschoorn, Adam J Luginbuhl, Athanassios Argiris, Ramez Philips, Angela Alnemri, Sruti Tekumalla, Hushan Yang, Alban Linnenbach, Diana Menezes, Voichita Bar-Ad, David Cognetti, Ramakrishna Mitra, Joseph M Curry

Predictive capacity of immune‐related adverse events and cytokine profiling in neoadjuvant immune checkpoint inhibitor trials for head and neck squamous cell carcinoma by Angela E. Alnemri, Sruti Tekumalla, Annie E. Moroco, Ioannis Vathiotis, Madalina Tuluc, Stacey Gargano, Tingting Zhan, David M. Cognetti, Joseph M. Curry, Athanassios Argiris, Alban Linnenbach, Andrew P. South, Larry A. Harshyne, Jennifer M. Johnson, Adam J. Luginbuhl

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222-K Integrated immunoprofiling and RNA sequencing (RNA-seq) for anti-PD-1 response prediction in head and neck squamous cell carcinomas (HNSCC) by Madalina Tuluc, Jennifer Johnson, Adam J Luginbuhl, Vladimir Kushnarev, Alexander Bagaev, Anastasia Nikitina, Alexander Zaytcev, Eric Mastrolonardo, Alban J Linnenbach, Anastasia Sobol, Tatiana Vasileva, Arseniy Sokolov, Daniiar Dyikanov, Evgeniia Alekseeva, Andrey Tyshevich, Christopher JH Davitt, Michael F Goldberg, Cagdas Tazearslan