Predicting binding to p-glycoprotein by flexible receptor docking. by Elena Dolghih, Clifford Bryant, Adam R Renslo, Matthew P Jacobson

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Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system. by Yaneth Osorio, Bruno L Travi, Adam R Renslo, Alex G Peniche, Peter C Melby

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Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis by Tesfahun Dessale Admasu, Kristie Kim, Michael Rae, Roberto Avelar, Ryan L. Gonciarz, Abdelhadi Rebbaa, João Pedro de Magalhães, Adam R. Renslo, Alexandra Stolzing, Amit Sharma

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Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei by Mari Nishino, Jonathan W Choy, Nathan N Gushwa, Juan A Oses-Prieto, Kyriacos Koupparis, Alma L Burlingame, Adam R Renslo, James H McKerrow, Jack Taunton

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cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool by Vladimir Camarena, David W Sant, Tyler C Huff, Sushmita Mustafi, Ryan K Muir, Allegra T Aron, Christopher J Chang, Adam R Renslo, Paula V Monje, Gaofeng Wang

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Correction: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei by Mari Nishino, Jonathan W Choy, Nathan N Gushwa, Juan A Oses-Prieto, Kyriacos Koupparis, Alma L Burlingame, Adam R Renslo, James H McKerrow, Jack Taunton

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Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. by Maha-Hamadien Abdulla, Debbie S Ruelas, Brian Wolff, June Snedecor, Kee-Chong Lim, Fengyun Xu, Adam R Renslo, Janice Williams, James H McKerrow, Conor R Caffrey

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch by Ciara M Gallagher, Carolina Garri, Erica L Cain, Kenny Kean-Hooi Ang, Christopher G Wilson, Steven Chen, Brian R Hearn, Priyadarshini Jaishankar, Andres Aranda-Diaz, Michelle R Arkin, Adam R Renslo, Peter Walter

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Mining a cathepsin inhibitor library for new antiparasitic drug leads. by Kenny K H Ang, Joseline Ratnam, Jiri Gut, Jennifer Legac, Elizabeth Hansell, Zachary B Mackey, Katarzyna M Skrzypczynska, Anjan Debnath, Juan C Engel, Philip J Rosenthal, James H McKerrow, Michelle R Arkin, Adam R Renslo

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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response by Carmela Sidrauski, Jordan C Tsai, Martin Kampmann, Brian R Hearn, Punitha Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S Mendez, Billy W Newton, Edward L Tang, Erik Verschueren, Jeffrey R Johnson, Nevan J Krogan, Christopher S Fraser, Jonathan S Weissman, Adam R Renslo, Peter Walter

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Pharmacological brake-release of mRNA translation enhances cognitive memory by Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter

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A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons by Gha-Hyun J Kim, Han Mo, Harrison Liu, Zhihao Wu, Steven Chen, Jiashun Zheng, Xiang Zhao, Daryl Nucum, James Shortland, Longping Peng, Mannuel Elepano, Benjamin Tang, Steven Olson, Nick Paras, Hao Li, Adam R Renslo, Michelle R Arkin, Bo Huang, Bingwei Lu, Marina Sirota, Su Guo

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Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads by Emma L. Gunderson, Clifford Bryant, Christina A. Bulman, Chelsea Fischer, Mona Luo, Ian Vogel, Kee-Chong Lim, Shabnam Jawahar, Nancy Tricoche, Denis Voronin, Christopher Corbo, Rene B. Ayiseh, Faustin P. T. Manfo, Glory E. Mbah, Fidelis Cho-Ngwa, Brenda Beerntsen, Adam R. Renslo, Sara Lustigman, Judy A. Sakanari

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Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. by Christopher E Heise, Jeremy Murray, Katherine E Augustyn, Brandon Bravo, Preeti Chugha, Frederick Cohen, Anthony M Giannetti, Paul Gibbons, Rami N Hannoush, Brian R Hearn, Priyadarshini Jaishankar, Cuong Q Ly, Kinjalkumar Shah, Karen Stanger, Micah Steffek, Yinyan Tang, Xianrui Zhao, Joseph W Lewcock, Adam R Renslo, John Flygare, Michelle R Arkin

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Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target by Jonathan W. Choy, Clifford Bryant, Claudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiri Gut, Juan A. Oses-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, James M. McKerrow, Larissa M. Podust, Adam R. Renslo

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