Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants by Scott C. Ritchie, Praveen Surendran, Savita Karthikeyan, Samuel A. Lambert, Thomas Bolton, Lisa Pennells, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Michael Inouye

Get full text

Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. by Peter Willeit, Julia Raschenberger, Emma E Heydon, Sotirios Tsimikas, Margot Haun, Agnes Mayr, Siegfried Weger, Joseph L Witztum, Adam S Butterworth, Johann Willeit, Florian Kronenberg, Stefan Kiechl

Get full text

Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis by Lucy J. Goudswaard, Laura J. Corbin, Kate L. Burley, Andrew Mumford, Parsa Akbari, Nicole Soranzo, Adam S. Butterworth, Nicholas A. Watkins, Dimitri J. Pournaras, Jessica Harris, Nicholas J. Timpson, Ingeborg Hers

Get full text

Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease by Yu Xu, Dragana Vuckovic, Scott C. Ritchie, Parsa Akbari, Tao Jiang, Jason Grealey, Adam S. Butterworth, Willem H. Ouwehand, David J. Roberts, Emanuele Di Angelantonio, John Danesh, Nicole Soranzo, Michael Inouye

Get full text

Risk Factors of Secondary Cardiovascular Events in a Multi-Ethnic Asian Population with Acute Myocardial Infarction: A Retrospective Cohort Study from Malaysia by Sophia Rasheeqa Ismail, Mohd Shawal Faizal Mohammad, Adam S. Butterworth, Rajiv Chowdhury, John Danesh, Emanuele Di Angelantonio, Simon J. Griffin, Lisa Pennells, Angela M. Wood, Mohd Fairulnizal Md Noh, Shamsul Azhar Shah

Get full text

Genetically personalised organ-specific metabolic models in health and disease by Carles Foguet, Yu Xu, Scott C. Ritchie, Samuel A. Lambert, Elodie Persyn, Artika P. Nath, Emma E. Davenport, David J. Roberts, Dirk S. Paul, Emanuele Di Angelantonio, John Danesh, Adam S. Butterworth, Christopher Yau, Michael Inouye

Get full text

The influence of rare variants in circulating metabolic biomarkers. by Fernando Riveros-Mckay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, INTERVAL Study, Eleanor Wheeler, Eleftheria Zeggini, Adam S Butterworth, Inês Barroso

Get full text

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease. by Manish D Paranjpe, Mark Chaffin, Sohail Zahid, Scott Ritchie, Jerome I Rotter, Stephen S Rich, Robert Gerszten, Xiuqing Guo, Susan Heckbert, Russ Tracy, John Danesh, Eric S Lander, Michael Inouye, Sekar Kathiresan, Adam S Butterworth, Amit V Khera

Get full text

Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank by Qingning Wang, Veryan Codd, Zahra Raisi-Estabragh, Crispin Musicha, Vasiliki Bountziouka, Stephen Kaptoge, Elias Allara, Emanuele Di Angelantonio, Adam S. Butterworth, Angela M. Wood, John R. Thompson, Steffen E Petersen, Nicholas C. Harvey, John N. Danesh, Nilesh J. Samani, Christopher P. Nelson

Get full text

Risk factors and prediction models for incident heart failure with reduced and preserved ejection fraction by Liam Gaziano, Kelly Cho, Luc Djousse, Petra Schubert, Ashley Galloway, Yuk‐Lam Ho, Katherine Kurgansky, David R. Gagnon, John P. Russo, Emanuele Di Angelantonio, Angela M. Wood, John Danesh, John Michael Gaziano, Adam S. Butterworth, Peter W.F. Wilson, Jacob Joseph

Get full text

Association of shorter leucocyte telomere length with risk of frailty by Vasiliki Bountziouka, Christopher P. Nelson, Veryan Codd, Qingning Wang, Crispin Musicha, Elias Allara, Stephen Kaptoge, Emanuele Di Angelantonio, Adam S. Butterworth, John R. Thompson, Elizabeth M. Curtis, Angela M. Wood, John N. Danesh, Nicholas C. Harvey, Cyrus Cooper, Nilesh J. Samani

Get full text

Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans by Susanna Lemmelä, Eleanor M Wigmore, Christian Benner, Aki S Havulinna, Rachel MY Ong, Tibor Kempf, Kai C Wollert, Stefan Blankenberg, Tanja Zeller, James E Peters, Veikko Salomaa, Maria Fritsch, Ruth March, Aarno Palotie, Mark Daly, Adam S Butterworth, Mervi Kinnunen, Dirk S Paul, Athena Matakidou

Get full text

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income by W. David Hill, Neil M. Davies, Stuart J. Ritchie, Nathan G. Skene, Julien Bryois, Steven Bell, Emanuele Di Angelantonio, David J. Roberts, Shen Xueyi, Gail Davies, David C. M. Liewald, David J. Porteous, Caroline Hayward, Adam S. Butterworth, Andrew M. McIntosh, Catharine R. Gale, Ian J. Deary

Get full text

Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses. by Luanluan Sun, Lisa Pennells, Stephen Kaptoge, Christopher P Nelson, Scott C Ritchie, Gad Abraham, Matthew Arnold, Steven Bell, Thomas Bolton, Stephen Burgess, Frank Dudbridge, Qi Guo, Eleni Sofianopoulou, David Stevens, John R Thompson, Adam S Butterworth, Angela Wood, John Danesh, Nilesh J Samani, Michael Inouye, Emanuele Di Angelantonio

Get full text

Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke by Lingyan Chen, James E. Peters, Bram Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova-Doing, Emanuele Di Angelantonio, David J. Roberts, Nicholas A. Watkins, Willem H. Ouwehand, John Danesh, Cathryn M. Lewis, Paola G. Bronson, Hugh S. Markus, Stephen Burgess, Adam S. Butterworth, Joanna M. M. Howson

Get full text

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. by Ricardo C Ferreira, Daniel F Freitag, Antony J Cutler, Joanna M M Howson, Daniel B Rainbow, Deborah J Smyth, Stephen Kaptoge, Pamela Clarke, Charlotte Boreham, Richard M Coulson, Marcin L Pekalski, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Adam S Butterworth, Anders Malarstig, John Danesh, John A Todd

Get full text

Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age by Sarah E. Harris, Simon R. Cox, Steven Bell, Riccardo E. Marioni, Bram P. Prins, Alison Pattie, Janie Corley, Susana Muñoz Maniega, Maria Valdés Hernández, Zoe Morris, Sally John, Paola G. Bronson, Elliot M. Tucker-Drob, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Adam S. Butterworth, Ian J. Deary

Get full text

Trans‐ethnic polygenic risk scores for body mass index: An international hundred K+ cohorts consortium study by Hui‐Qi Qu, John J Connolly, Peter Kraft, Jirong Long, Alexandre Pereira, Christopher Flatley, Constance Turman, Bram Prins, Frank Mentch, Paulo A Lotufo, Per Magnus, Meir J Stampfer, Rulla Tamimi, A Heather Eliassen, Wei Zheng, Gun Peggy Stromstad Knudsen, Oyvind Helgeland, Adam S. Butterworth, Hakon Hakonarson, Patrick M. Sleiman, the IHCC consortium

Get full text

Author Correction: Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease by Chen Yao, George Chen, Ci Song, Joshua Keefe, Michael Mendelson, Tianxiao Huan, Benjamin B. Sun, Annika Laser, Joseph C. Maranville, Hongsheng Wu, Jennifer E. Ho, Paul Courchesne, Asya Lyass, Martin G. Larson, Christian Gieger, Johannes Graumann, Andrew D. Johnson, John Danesh, Heiko Runz, Shih-Jen Hwang, Chunyu Liu, Adam S. Butterworth, Karsten Suhre, Daniel Levy

Get full text

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. by Leonardo Bottolo, Marc Chadeau-Hyam, David I Hastie, Tanja Zeller, Benoit Liquet, Paul Newcombe, Loic Yengo, Philipp S Wild, Arne Schillert, Andreas Ziegler, Sune F Nielsen, Adam S Butterworth, Weang Kee Ho, Raphaële Castagné, Thomas Munzel, David Tregouet, Mario Falchi, François Cambien, Børge G Nordestgaard, Fredéric Fumeron, Anne Tybjærg-Hansen, Philippe Froguel, John Danesh, Enrico Petretto, Stefan Blankenberg, Laurence Tiret, Sylvia Richardson

Get full text