Inhibition of EGFR signaling: all mutations are not created equal. by Adi F Gazdar, John D Minna

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TP53 Abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma§ by Mauricio Moreno, Fernando Pimentel, Adi F. Gazdar, Ignacio I. Wistuba, Juan F. Miquel

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Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures by Luka Brcic, Christian Kuchler, Sylvia Eidenhammer, Daniela Pabst, Franz Quehenberger, Adi F. Gazdar, Helmut Popper

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SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II–III Diffuse Gliomas by Yu-An Zhang, Yunyun Zhou, Xin Luo, Kai Song, Xiaotu Ma, Adwait Sathe, Luc Girard, Guanghua Xiao, Adi F Gazdar

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ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration by Jia-Hao Bi, Yi-Fan Tong, Zhe-Wei Qiu, Xing-Feng Yang, John Minna, Adi F. Gazdar, Kai Song

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Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer. by Bradley P Coe, Kelsie L Thu, Sarit Aviel-Ronen, Emily A Vucic, Adi F Gazdar, Stephen Lam, Ming-Sound Tsao, Wan L Lam

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The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors by Min He, Shanshan Liu, Sachith Gallolu Kankanamalage, Mark D. Borromeo, Luc Girard, Adi F. Gazdar, John D. Minna, Jane E. Johnson, Melanie H. Cobb

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Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. by Jessica Kao, Keyan Salari, Melanie Bocanegra, Yoon-La Choi, Luc Girard, Jeet Gandhi, Kevin A Kwei, Tina Hernandez-Boussard, Pei Wang, Adi F Gazdar, John D Minna, Jonathan R Pollack

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ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs by Mark D. Borromeo, Trisha K. Savage, Rahul K. Kollipara, Min He, Alexander Augustyn, Jihan K. Osborne, Luc Girard, John D. Minna, Adi F. Gazdar, Melanie H. Cobb, Jane E. Johnson

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Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. by Jeet Gandhi, Jianling Zhang, Yang Xie, Junichi Soh, Hisayuki Shigematsu, Wei Zhang, Hiromasa Yamamoto, Michael Peyton, Luc Girard, William W Lockwood, Wan L Lam, Marileila Varella-Garcia, John D Minna, Adi F Gazdar

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Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability. by Kelsie L Thu, Emily A Vucic, Raj Chari, Wei Zhang, William W Lockwood, John C English, Rong Fu, Pei Wang, Ziding Feng, Calum E MacAulay, Adi F Gazdar, Stephen Lam, Wan L Lam

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SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers by Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A. Wheeler, John D. Minna, Michael A. White, Adi F. Gazdar, Michael G. Roth

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miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. by Liqin Du, Maria C Subauste, Christopher DeSevo, Zhenze Zhao, Michael Baker, Robert Borkowski, Jeoffrey J Schageman, Rachel Greer, Chin-Rang Yang, Milind Suraokar, Ignacio I Wistuba, Adi F Gazdar, John D Minna, Alexander Pertsemlidis

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Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers. by Masaharu Nomura, Hisayuki Shigematsu, Lin Li, Makoto Suzuki, Takao Takahashi, Pila Estess, Mark Siegelman, Ziding Feng, Harubumi Kato, Antonio Marchetti, Jerry W Shay, Margaret R Spitz, Ignacio I Wistuba, John D Minna, Adi F Gazdar

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Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. by Junichi Soh, Naoki Okumura, William W Lockwood, Hiromasa Yamamoto, Hisayuki Shigematsu, Wei Zhang, Raj Chari, David S Shames, Ximing Tang, Calum MacAulay, Marileila Varella-Garcia, Tõnu Vooder, Ignacio I Wistuba, Stephen Lam, Rolf Brekken, Shinichi Toyooka, John D Minna, Wan L Lam, Adi F Gazdar

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Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis by Hans K. Ghayee, Yiling Xu, Heather Hatch, Richard Brockway, Asha S. Multani, Tongjun Gu, Wendy B. Bollag, Adina Turcu, William E. Rainey, Juilee Rege, Kazutaka Nanba, Vikash J. Bhagwandin, Fiemu Nwariaku, Victor Stastny, Adi F. Gazdar, Jerry W. Shay, Richard J. Auchus, Sergei G. Tevosian

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Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor. by Hans K Ghayee, Vikash J Bhagwandin, Victor Stastny, Arielle Click, Liang-Hao Ding, Dario Mizrachi, Ying S Zou, Raj Chari, Wan L Lam, Robert M Bachoo, Alice L Smith, Michael D Story, Stan Sidhu, Bruce G Robinson, Fiemu E Nwariaku, Adi F Gazdar, Richard J Auchus, Jerry W Shay

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Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma. by William W Lockwood, Raj Chari, Bradley P Coe, Kelsie L Thu, Cathie Garnis, Chad A Malloff, Jennifer Campbell, Ariane C Williams, Dorothy Hwang, Chang-Qi Zhu, Timon P H Buys, John Yee, John C English, Calum Macaulay, Ming-Sound Tsao, Adi F Gazdar, John D Minna, Stephen Lam, Wan L Lam

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Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development. by William W Lockwood, Ian M Wilson, Bradley P Coe, Raj Chari, Larissa A Pikor, Kelsie L Thu, Luisa M Solis, Maria I Nunez, Carmen Behrens, John Yee, John English, Nevin Murray, Ming-Sound Tsao, John D Minna, Adi F Gazdar, Ignacio I Wistuba, Calum E MacAulay, Stephen Lam, Wan L Lam

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A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. by David S Shames, Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M Lewis, Narayan Shivapurkar, Aixiang Jiang, Charles M Perou, Young H Kim, Jonathan R Pollack, Kwun M Fong, Chi-Leung Lam, Maria Wong, Yu Shyr, Rita Nanda, Olufunmilayo I Olopade, William Gerald, David M Euhus, Jerry W Shay, Adi F Gazdar, John D Minna

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