783 Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: a report from the International RRD consortium by Birgit Ertl-Wagner, Uri Tabori, Adrian Levine, Trevor Pugh, Anirban Das, Nicholas Fernandez, Vanessa Bianchi, Lucie Stengs, Melissa Edwards, Derek Tsang, Daniel Morgenstern, Cynthia Hawkins, Eric Bouffet