The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis by Md. Aejazur Rahman, Joel N. Glasgow, Sajid Nadeem, Vineel P. Reddy, Ritesh R. Sevalkar, Jack R. Lancaster, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn

Get full text

Heme Oxygenase-1 as a Pharmacological Target for Host-Directed Therapy to Limit Tuberculosis Associated Immunopathology by Krishna C. Chinta, Hayden T. Pacl, Anupam Agarwal, Adrie J. C. Steyn

Get full text

Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection by Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Joel N. Glasgow, Travis D. Hull, Amie Traylor, Fernanda Rey-Stolle, Miguel P. Soares, Rajhmun Madansein, Md Aejazur Rahman, Coral Barbas, Kievershen Nargan, Threnesan Naidoo, Pratistadevi K. Ramdial, James F. George, Anupam Agarwal, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn

Get full text

Use of telepathology to facilitate COVID-19 research and education through an online COVID-19 autopsy biorepository by Paul V Benson, Silvio H Litovsky, Adrie J C Steyn, Camilla Margaroli, Egiebade Iriabho, Peter G Anderson

Get full text

Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish by Zhenkang Chen, Yangbo Hu, Bridgette M. Cumming, Pei Lu, Lipeng Feng, Jiaoyu Deng, Adrie J.C. Steyn, Shiyun Chen

Get full text

A Feedback Regulatory Loop Containing McdR and WhiB2 Controls Cell Division and DNA Repair in Mycobacteria by Wei Zhou, Shaojia Huang, Bridgette M. Cumming, Yong Zhang, Wei Tang, Adrie J. C. Steyn, Shiyun Chen, Yangbo Hu

Get full text

Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response. by Amit Singh, David K Crossman, Deborah Mai, Loni Guidry, Martin I Voskuil, Matthew B Renfrow, Adrie J C Steyn

Get full text

Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Mycobacterium tuberculosis Expressed Determinants by Micah D. Dunlap, Micah D. Dunlap, Oliver A. Prince, Javier Rangel-Moreno, Kimberly A. Thomas, Julia M. Scordo, Jordi B. Torrelles, Jeffery Cox, Adrie J. C. Steyn, Adrie J. C. Steyn, Joaquín Zúñiga, Deepak Kaushal, Deepak Kaushal, Deepak Kaushal, Shabaana A. Khader, Shabaana A. Khader

Get full text

LiLA: lipid lung-based ATLAS built through a comprehensive workflow designed for an accurate lipid annotation by Belén Fernández Requena, Sajid Nadeem, Vineel P. Reddy, Vanessa Naidoo, Joel N. Glasgow, Adrie J. C. Steyn, Coral Barbas, Carolina Gonzalez-Riano

Get full text

Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response by Hylton E. Rodel, Hylton E. Rodel, Isabella A. T. M. Ferreira, Carly G. K. Ziegler, Carly G. K. Ziegler, Carly G. K. Ziegler, Carly G. K. Ziegler, Yashica Ganga, Mallory Bernstein, Shi-Hsia Hwa, Shi-Hsia Hwa, Kievershen Nargan, Gila Lustig, Gilla Kaplan, Mahdad Noursadeghi, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn, Alex Sigal, Alex Sigal, Alex Sigal, Alex Sigal

Get full text

Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection. by Bridgette M Cumming, Md Aejazur Rahman, Dirk A Lamprecht, Kyle H Rohde, Vikram Saini, John H Adamson, David G Russell, Adrie J C Steyn

Get full text

Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection. by Bridgette M Cumming, Md Aejazur Rahman, Dirk A Lamprecht, Kyle H Rohde, Vikram Saini, John H Adamson, David G Russell, Adrie J C Steyn

Get full text

B cells promote granulomatous inflammation during chronic Mycobacterium tuberculosis infection in mice. by Yong Chen, Sushma Bharrhan, Jiayong Xu, Tarina Sharma, Yanhua Wang, Padmini Salgame, Jinghang Zhang, Kievershen Nargan, Adrie J C Steyn, Paul J Maglione, John Chan

Get full text

A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing by Harriet D. Gliddon, Dan Frampton, Vanisha Munsamy, Jude Heaney, Thomas Pataillot-Meakin, Eleni Nastouli, Alexander S. Pym, Adrie J. C. Steyn, Deenan Pillay, Rachel A. McKendry

Get full text

NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis by Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kievershen Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn

Get full text

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> by Caroline S. Foo, Andréanne Lupien, Maryline Kienle, Anthony Vocat, Andrej Benjak, Raphael Sommer, Dirk A. Lamprecht, Adrie J. C. Steyn, Kevin Pethe, Jérémie Piton, Karl-Heinz Altmann, Stewart T. Cole

Get full text

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection by Shannon L. Russell, Dirk A. Lamprecht, Tawanda Mandizvo, Terrence T. Jones, Vanessa Naidoo, Kelvin W. Addicott, Chivonne Moodley, Bongani Ngcobo, David K. Crossman, Gordon Wells, Adrie J.C. Steyn

Get full text

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis. by Andréanne Lupien, Caroline Shi-Yan Foo, Svetlana Savina, Anthony Vocat, Jérémie Piton, Natalia Monakhova, Andrej Benjak, Dirk A Lamprecht, Adrie J C Steyn, Kevin Pethe, Vadim A Makarov, Stewart T Cole

Get full text

Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the DosR dormancy regulon by Ritesh R. Sevalkar, Joel N. Glasgow, Martín Pettinati, Marcelo A. Marti, Vineel P. Reddy, Swati Basu, Elmira Alipour, Daniel B. Kim-Shapiro, Dario A. Estrin, Jack R. Lancaster, Jr., Adrie J.C. Steyn

Get full text

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10 by Mohamed Ahmed, Jared Mackenzie, Liku Tezera, Robert Krause, Barry Truebody, Diana Garay-Baquero, Andres Vallejo, Katya Govender, John Adamson, Hayden Fisher, Jonathan W. Essex, Salah Mansour, Paul Elkington, Adrie J. C. Steyn, Alasdair Leslie

Get full text