The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets by Thalhammer, A, Aik, W, Bagg, E, Schofield, C

The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets by Thalhammer, A, Aik, W, Bagg, E, Schofield, C

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. by Aik, W, McDonough, M, Thalhammer, A, Chowdhury, R, Schofield, C

Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. by Xu, C, Liu, K, Tempel, W, Demetriades, M, Aik, W, Schofield, C, Min, J

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation by Aik, W, Scotti, J, Choi, H, Gong, L, Demetriades, M, Schofield, C, McDonough, M

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. by Aik, W, Scotti, J, Choi, H, Gong, L, Demetriades, M, Schofield, C, McDonough, M

Structural basis for inhibition of the fat mass and obesity associated protein (FTO). by Aik, W, Demetriades, M, Hamdan, M, Bagg, E, Yeoh, K, Lejeune, C, Zhang, Z, McDonough, M, Schofield, C

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases by Horita, S, Scotti, J, Thinnes, C, Taromsari, Y, Thalhammer, A, Ge, W, Aik, W, Loenarz, C, Schofield, C, McDonough, M

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. by Brem, J, van Berkel, S, Aik, W, Rydzik, A, Avison, M, Pettinati, I, Umland, K, Kawamura, A, Spencer, J, Claridge, T, McDonough, M, Schofield, C

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. by Woon, E, Demetriades, M, Bagg, E, Aik, W, Krylova, S, Ma, J, Chan, M, Walport, L, Wegman, D, Dack, K, McDonough, M, Krylov, SN, Schofield, C

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. by Scotti, J, Leung, I, Ge, W, Bentley, M, Paps, J, Kramer, H, Lee, J, Aik, W, Choi, H, Paulsen, S, Bowman, L, Loik, N, Horita, S, Ho, C, Kershaw, N, Tang, C, Claridge, T, Preston, G, McDonough, M, Schofield, C

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation by Hopkinson, R, Tumber, A, Yapp, C, Chowdhury, R, Aik, W, Che, K, Li, X, Kristensen, J, King, O, Chan, M, Yeoh, K, Choi, H, Walport, L, Thinnes, C, Bush, J, Lejeune, C, Rydzik, A, Rose, N, Bagg, E, McDonough, M, Krojer, T, Yue, W, Ng, S, Olsen, L, Brennan, P

Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis by Eveline M. Delemarre, Eveline M. Delemarre, Laura van Hoorn, Laura van Hoorn, Aik W. J. Bossink, Julia Drylewicz, Simone A. Joosten, Tom H. M. Ottenhoff, Onno W. Akkerman, Delia Goletti, Elisa Petruccioli, Assunta Navarra, Brigitte T. A. van den Broek, Sanne P. A. Paardekooper, Ineke van Haeften, Leo Koenderman, Leo Koenderman, Jan-Willem J. Lammers, Steven F. T. Thijsen, Regina W. Hofland, Regina W. Hofland, Stefan Nierkens, Stefan Nierkens

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The diagnostic value of nasal microbiota and clinical parameters in a multi-parametric prediction model to differentiate bacterial versus viral infections in lower respiratory trac... by Yunlei Li, Chantal B van Houten, Stefan A Boers, Ruud Jansen, Asi Cohen, Dan Engelhard, Robert Kraaij, Saskia D Hiltemann, Jie Ju, David Fernández, Cristian Mankoc, Eva González, Wouter J de Waal, Karin M de Winter-de Groot, Tom F W Wolfs, Pieter Meijers, Bart Luijk, Jan Jelrik Oosterheert, Sanjay U C Sankatsing, Aik W J Bossink, Michal Stein, Adi Klein, Jalal Ashkar, Ellen Bamberger, Isaac Srugo, Majed Odeh, Yaniv Dotan, Olga Boico, Liat Etshtein, Meital Paz, Roy Navon, Tom Friedman, Einav Simon, Tanya M Gottlieb, Ester Pri-Or, Gali Kronenfeld, Kfir Oved, Eran Eden, Andrew P Stubbs, Louis J Bont, John P Hays

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The diagnostic value of nasal microbiota and clinical parameters in a multi-parametric prediction model to differentiate bacterial versus viral infections in lower respiratory trac... by Yunlei Li, Chantal B. van Houten, Stefan A. Boers, Ruud Jansen, Asi Cohen, Dan Engelhard, Robert Kraaij, Saskia D. Hiltemann, Jie Ju, David Fernández, Cristian Mankoc, Eva González, Wouter J. de Waal, Karin M. de Winter-de Groot, Tom F. W. Wolfs, Pieter Meijers, Bart Luijk, Jan Jelrik Oosterheert, Sanjay U. C. Sankatsing, Aik W. J. Bossink, Michal Stein, Adi Klein, Jalal Ashkar, Ellen Bamberger, Isaac Srugo, Majed Odeh, Yaniv Dotan, Olga Boico, Liat Etshtein, Meital Paz, Roy Navon, Tom Friedman, Einav Simon, Tanya M. Gottlieb, Ester Pri-Or, Gali Kronenfeld, Kfir Oved, Eran Eden, Andrew P. Stubbs, Louis J. Bont, John P. Hays

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