Article Commentary: Should We Consider Cancers as Embryonic Diseases or as Consequences of Stem-Cell Deregulation? by Jérémy Bastid, Alain Puisieux, Stéphane Ansieau

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The cell-of-origin dictates the genomic landscape of breast cancers by Alain Puisieux, Roxane M. Pommier, Agnès Tissier, Anne-Pierre Morel

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Quantifying local malignant adaptation in tissue‐specific evolutionary trajectories by harnessing cancer’s repeatability at the genetic level by Natsuki Tokutomi, Caroline Moyret‐Lalle, Alain Puisieux, Sumio Sugano, Pierre Martinez

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Cellular Plasticity: A Route to Senescence Exit and Tumorigenesis by Hadrien De Blander, Anne-Pierre Morel, Aruni P. Senaratne, Maria Ouzounova, Alain Puisieux

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Assessing Cell Activities rather than Identities to Interpret Intra-Tumor Phenotypic Diversity and Its Dynamics by Laloé Monteiro, Lydie Da Silva, Boris Lipinski, Frédérique Fauvet, Arnaud Vigneron, Alain Puisieux, Pierre Martinez

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Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. by Baptiste Gras, Laurent Jacqueroud, Anne Wierinckx, Christelle Lamblot, Frédérique Fauvet, Joël Lachuer, Alain Puisieux, Stéphane Ansieau

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Intestinal Epithelial Cells Adapt to Chronic Inflammation through Partial Genetic Reprogramming by Guillaume Collin, Jean-Philippe Foy, Nicolas Aznar, Nicolas Rama, Anne Wierinckx, Pierre Saintigny, Alain Puisieux, Stéphane Ansieau

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Modulation of oxidative stress by twist oncoproteins. by Nicolas Floc'h, Jakub Kolodziejski, Leila Akkari, Yannick Simonin, Stéphane Ansieau, Alain Puisieux, Urszula Hibner, Patrice Lassus

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The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells by Laurent Jacqueroud, Charlotte Bouard, Geoffrey Richard, Léa Payen, Mojgan Devouassoux-Shisheboran, Douglas B. Spicer, Julie Caramel, Guillaume Collin, Alain Puisieux, Agnès Tissier, Stéphane Ansieau

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Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution by Roxane M. Pommier, Amélien Sanlaville, Laurie Tonon, Janice Kielbassa, Emilie Thomas, Anthony Ferrari, Anne-Sophie Sertier, Frédéric Hollande, Pierre Martinez, Agnès Tissier, Anne-Pierre Morel, Maria Ouzounova, Alain Puisieux

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TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma. by Karine Pallier, Anatole Cessot, Jean-Francois Côté, Pierre-Alexandre Just, Aurélie Cazes, Elizabeth Fabre, Claire Danel, Marc Riquet, Mojgan Devouassoux-Shisheboran, Stéphane Ansieau, Alain Puisieux, Pierre Laurent-Puig, Hélène Blons

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A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes by Jean-Philippe Foy, Louis Bazire, Sandra Ortiz-Cuaran, Sophie Deneuve, Janice Kielbassa, Emilie Thomas, Alain Viari, Alain Puisieux, Patrick Goudot, Chloé Bertolus, Nicolas Foray, Youlia Kirova, Pierre Verrelle, Pierre Saintigny

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ZEB1 transcription factor promotes immune escape in melanoma by Christophe Caux, Stephane Dalle, Arnaud de la Fouchardière, Laurie Tonon, Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Julie Caramel

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EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice. by Anne-Pierre Morel, George W Hinkal, Clémence Thomas, Frédérique Fauvet, Stéphanie Courtois-Cox, Anne Wierinckx, Mojgan Devouassoux-Shisheboran, Isabelle Treilleux, Agnès Tissier, Baptiste Gras, Julie Pourchet, Isabelle Puisieux, Gareth J Browne, Douglas B Spicer, Joël Lachuer, Stéphane Ansieau, Alain Puisieux

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Immunological and classical subtypes of oral premalignant lesions by Jean-Philippe Foy, Chloé Bertolus, Sandra Ortiz-Cuaran, Marie-Alexandra Albaret, William N Williams, Wenhua Lang, Solène Destandau, Geneviève De Souza, Emilie Sohier, Janice Kielbassa, Emilie Thomas, Sophie Deneuve, Patrick Goudot, Alain Puisieux, Alain Viari, Li Mao, Christophe Caux, SM Lippman, P Saintigny

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CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity by Maha Siouda, Audrey D. Dujardin, Laetitia Barbollat-Boutrand, Marco A. Mendoza-Parra, Benjamin Gibert, Maria Ouzounova, Jebrane Bouaoud, Laurie Tonon, Marie Robert, Jean-Philippe Foy, Vincent Lavergne, Serge N. Manie, Alain Viari, Alain Puisieux, Gabriel Ichim, Hinrich Gronemeyer, Pierre Saintigny, Peter Mulligan

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Correction: Inactivation of TIF1γ Cooperates with Kras to Induce Cystic Tumors of the Pancreas. by David F. Vincent, Kai-Ping Yan, Isabelle Treilleux, Fabien Gay, Vanessa Arfi, Bastien Kaniewski, Julien C. Marie, Florian Lepinasse, Sylvie Martel, Sophie Goddard-Leon, Juan L. Iovanna, Pierre Dubus, Stéphane Garcia, Alain Puisieux, Ruth Rimokh, Nabeel Bardeesy, Jean-Yves Scoazec, Régine Losson, Laurent Bartholin

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Low level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer by Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel

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