Detection of NRAS Mutation in Kaposiform Lymphangiomatosis Using Cell-free DNA from Plasma by Fiona Lynch, Veronika Dvorakova, Alan D. Irvine

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Model-Based Meta-Analysis to Optimize Staphylococcus aureus‒Targeted Therapies for Atopic Dermatitis by Takuya Miyano, Alan D. Irvine, Reiko J. Tanaka

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Peripheral Blood Gene Expression Profile of Infants with Atopic Dermatitis by Janna Nousbeck, Maeve A. McAleer, Alan D. Irvine

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Study protocol: assessing SleeP IN infants with early-onset atopic Dermatitis by Longitudinal Evaluation (The SPINDLE study) by Cathal O’Connor, Alan D. Irvine, Deirdre Murray, Michelle Murphy, Jonathan O’B Hourihane, Geraldine Boylan

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Changes in nano-mechanical properties of human epidermal cornified cells in children with atopic dermatitis [version 2; peer review: 2 approved] by Marek Haftek, Maeve A McAleer, Ivone Jakasa, WH Irwin McLean, Sanja Kezic, Alan D. Irvine

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A real‐world retrospective observational study exploring resource use for secondary care management of moderate‐to‐severe atopic dermatitis in children and adolescents at a single... by Alan D. Irvine, Thishi Surendranathan, Liz Hennessy, Ivana Rajkovic, Annette Durkan, Dearbhla Coughlan, Sean Conlon, Richard Hudson

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Efficacy of Sirolimus in Patients Requiring Tracheostomy for Life-Threatening Lymphatic Malformation of the Head and Neck: A Report From the European Reference Network by Annegret Holm, Annegret Holm, Maroeska te Loo, Maroeska te Loo, Leo Schultze Kool, Leo Schultze Kool, Päivi Salminen, Päivi Salminen, Veronica Celis, Eulalia Baselga, Sophie Duignan, Sophie Duignan, Sophie Duignan, Sophie Duignan, Veronika Dvorakova, Veronika Dvorakova, Veronika Dvorakova, Veronika Dvorakova, Alan D. Irvine, Alan D. Irvine, Alan D. Irvine, Alan D. Irvine, Laurence M. Boon, Laurence M. Boon, Miikka Vikkula, Miikka Vikkula, Miikka Vikkula, Nader Ghaffarpour, Nader Ghaffarpour, Charlotte M. Niemeyer, Charlotte M. Niemeyer, Jochen Rössler, Jochen Rössler, Jochen Rössler, Friedrich G. Kapp, Friedrich G. Kapp

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Novel mixed-method, inclusive protocol involving global key stakeholders, including carers as experts, to co-develop relevant Caregiver-Reported Outcome Domains (CRODs) in skin dis... by Anthony Bewley, Fiona Browne, Alan D Irvine, Gerard Leavey, Amy S Paller, Jemima E Mellerio, Carleen Walsh, Marian Mc Laughlin

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Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children—the MAGPIE trial (MEOF-002): study protocol for a randomised controlled trial by Stuart Hartshorn, Michael J. Barrett, Mark D. Lyttle, Sue Anne Yee, Alan T. Irvine, in collaboration with Paediatric Emergency Research in the UK and Ireland (PERUKI)

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Clinical experience with the AKT1 inhibitor miransertib in two children with PIK3CA-related overgrowth syndrome by Karina Forde, Nicoletta Resta, Carlotta Ranieri, David Rea, Olga Kubassova, Mark Hinton, Katrina A. Andrews, Robert Semple, Alan D. Irvine, Veronika Dvorakova

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Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort. by Santiago Rodriguez, Amanda J Hall, Raquel Granell, W H Irwin McLean, Alan D Irvine, Colin N A Palmer, George Davey Smith, John Henderson, Ian N M Day

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Safety profile of upadacitinib over 15 000 patient-years across rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and atopic dermatitis by Peter Nash, Atul Deodhar, Philip J Mease, Yoshiya Tanaka, Tim Shaw, Gerd R Burmester, Kevin L Winthrop, Alan D Irvine, Eduardo Mysler, Stanley B Cohen, Ana P Lacerda, John Liu, Hannah Palac, Emma Guttman‑Yassky

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Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy. by Haihui Liao, Alan D Irvine, Caroline J Macewen, Kathryn H Weed, Louise Porter, Laura D Corden, A Bethany Gibson, Jonathan E Moore, Frances J D Smith, W H Irwin McLean, C B Tara Moore

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Safety and Efficacy of Lebrikizumab in Adolescent Patients with Moderate-to-Severe Atopic Dermatitis: A 52-Week, Open-Label, Phase 3 Study by Amy S. Paller, Carsten Flohr, Lawrence F. Eichenfield, Alan D. Irvine, Jamie Weisman, Jennifer Soung, Ana Pinto Correia, Chitra R. Natalie, Claudia Rodriguez Capriles, Evangeline Pierce, Sarah Reifeis, Renata Gontijo Lima, Clara Armengol Tubau, Vivian Laquer, Stephan Weidinger

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The VASCERN-VASCA Working Group Diagnostic and Management Pathways for Venous Malformations by Anne Dompmartin, Eulalia Baselga, Laurence M. Boon, Andrea Diociaiuti, Veronika Dvorakova, May El Hachem, Paolo Gasparella, Emir Haxhija, Nader Ghaffarpour, Kristiina Kyrklund, Alan D. Irvine, Friedrich G. Kapp, Jochen Rößler, Päivi Salminen, Caroline van den Bosch, Carine van der Vleuten, Leo Schultze Kool, Miikka Vikkula

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Meta-Analysis of Mutations in <i>ALOX12B</i> or <i>ALOXE3</i> Identified in a Large Cohort of 224 Patients by Alrun Hotz, Julia Kopp, Emmanuelle Bourrat, Vinzenz Oji, Katalin Komlosi, Kathrin Giehl, Bakar Bouadjar, Anette Bygum, Iliana Tantcheva-Poor, Maritta Hellström Pigg, Cristina Has, Zhou Yang, Alan D. Irvine, Regina C. Betz, Giovanna Zambruno, Gianluca Tadini, Kira Süßmuth, Robert Gruber, Matthias Schmuth, Juliette Mazereeuw-Hautier, Natalie Jonca, Sophie Guez, Michela Brena, Angela Hernandez-Martin, Peter van den Akker, Maria C. Bolling, Katariina Hannula-Jouppi, Andreas D. Zimmer, Svenja Alter, Anders Vahlquist, Judith Fischer

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Comparison of real-world treatment outcomes of systemic immunomodulating therapy in atopic dermatitis patients with dark and light skin typesCapsule Summary by Angela L. Bosma, MD, Wouter Ouwerkerk, PhD, Madeline J. Heidema, MD, David Prieto-Merino, PhD, Michael R. Ardern-Jones, MD, PhD, Paula Beattie, MD, Sara J. Brown, MD, PhD, John R. Ingram, MD, PhD, Alan D. Irvine, MD, DSc, Graham Ogg, MD, PhD, Prakash Patel, BSc, Nick J. Reynolds, MD, PhD, R.M. Ross Hearn, MD, Mandy Wan, PhD, Richard B. Warren, MD, PhD, Richard T. Woolf, MD, PhD, Ariënna M. Hyseni, Louise A.A. Gerbens, MD, PhD, Phyllis I. Spuls, MD, PhD, Carsten Flohr, MD, PhD, Maritza A. Middelkamp-Hup, MD, PhD

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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation by Ashley Budu-Aggrey, Anna Kilanowski, Maria K. Sobczyk, 23andMe Research Team, Suyash S. Shringarpure, Ruth Mitchell, Kadri Reis, Anu Reigo, Estonian Biobank Research Team, Reedik Mägi, Mari Nelis, Nao Tanaka, Ben M. Brumpton, Laurent F. Thomas, Pol Sole-Navais, Christopher Flatley, Antonio Espuela-Ortiz, Esther Herrera-Luis, Jesus V. T. Lominchar, Jette Bork-Jensen, Ingo Marenholz, Aleix Arnau-Soler, Ayoung Jeong, Katherine A. Fawcett, Hansjorg Baurecht, Elke Rodriguez, Alexessander Couto Alves, Ashish Kumar, Patrick M. Sleiman, Xiao Chang, Carolina Medina-Gomez, Chen Hu, Cheng-jian Xu, Cancan Qi, Sarah El-Heis, Philip Titcombe, Elie Antoun, João Fadista, Carol A. Wang, Elisabeth Thiering, Baojun Wu, Sara Kress, Dilini M. Kothalawala, Latha Kadalayil, Jiasong Duan, Hongmei Zhang, Sabelo Hadebe, Thomas Hoffmann, Eric Jorgenson, Hélène Choquet, Neil Risch, Pål Njølstad, Ole A. Andreassen, Stefan Johansson, Catarina Almqvist, Tong Gong, Vilhelmina Ullemar, Robert Karlsson, Patrik K. E. Magnusson, Agnieszka Szwajda, Esteban G. Burchard, Jacob P. Thyssen, Torben Hansen, Line L. Kårhus, Thomas M. Dantoft, Alexander C.S.N. Jeanrenaud, Ahla Ghauri, Andreas Arnold, Georg Homuth, Susanne Lau, Markus M. Nöthen, Norbert Hübner, Medea Imboden, Alessia Visconti, Mario Falchi, Veronique Bataille, Pirro Hysi, Natalia Ballardini, Dorret I. Boomsma, Jouke J. Hottenga, Martina Müller-Nurasyid, Tarunveer S. Ahluwalia, Jakob Stokholm, Bo Chawes, Ann-Marie M. Schoos, Ana Esplugues, Mariona Bustamante, Benjamin Raby, Syed Arshad, Chris German, Tõnu Esko, Lili A. Milani, Andres Metspalu, Chikashi Terao, Katrina Abuabara, Mari Løset, Kristian Hveem, Bo Jacobsson, Maria Pino-Yanes, David P. Strachan, Niels Grarup, Allan Linneberg, Young-Ae Lee, Nicole Probst-Hensch, Stephan Weidinger, Marjo-Riitta Jarvelin, Erik Melén, Hakon Hakonarson, Alan D. Irvine, Deborah Jarvis, Tamar Nijsten, Liesbeth Duijts, Judith M. Vonk, Gerard H. Koppelmann, Keith M. Godfrey, Sheila J. Barton, Bjarke Feenstra, Craig E. Pennell, Peter D. Sly, Patrick G. Holt, L. Keoki Williams, Hans Bisgaard, Klaus Bønnelykke, John Curtin, Angela Simpson, Clare Murray, Tamara Schikowski, Supinda Bunyavanich, Scott T. Weiss, John W. Holloway, Josine L. Min, Sara J. Brown, Marie Standl, Lavinia Paternoster

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