497 PTT-4256 is a first-in-class small molecule inhibitor of GPR65 that counteracts the low pH-dependent immunosuppressive effects on immune cells and displays pronounced anti-tumo... by David Miller, Alastair Corbin, Barbara Young, Preeti Singh, Tobias Bopp, Darryl Turner, Barbara Cipriani, Alan Naylor, Gavin Milne, Rupert Satchell, Mussa Quareshy, Sourav Sarkar, Tobias Moechel, Philip MacFaul, Stuart Paine, Oliver Horne, Jessica Holien, Anastasia Nika, Gavin Knox, Toszka Bohn, Tom McCarthy, Stuart Hughes