Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability. nork Raimondo, A, Chakera, A, Thomsen, S, Colclough, K, Barrett, A, De Franco, E, Chatelas, A, Demirbilek, H, Akcay, T, Alawneh, H, Flanagan, SE, Van De Bunt, M, Hattersley, A, Gloyn, A, Ellard, S