Heterogeneity in white blood cells has potential to confound DNA methylation measurements. by Bjorn T Adalsteinsson, Haukur Gudnason, Thor Aspelund, Tamara B Harris, Lenore J Launer, Gudny Eiriksdottir, Albert V Smith, Vilmundur Gudnason

Get full text

FixItFelix: improving genomic analysis by fixing reference errors by Sairam Behera, Jonathon LeFaive, Peter Orchard, Medhat Mahmoud, Luis F. Paulin, Jesse Farek, Daniela C. Soto, Stephen C. J. Parker, Albert V. Smith, Megan Y. Dennis, Justin M. Zook, Fritz J. Sedlazeck

Get full text

GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing by Ravi Mathur, Fang Fang, Nathan Gaddis, Dana B. Hancock, Michael H. Cho, John E. Hokanson, Laura J. Bierut, Sharon M. Lutz, Kendra Young, Albert V. Smith, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Edwin K. Silverman, Grier P. Page, Eric O. Johnson

Get full text

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study by Carina Törn, Xiang Liu, Suna Onengut-Gumuscu, Kevin M. Counts, Jose Leonardo Moreno, Cassandra L. Remedios, Wei-Min Chen, Jonathon LeFaive, Martha D. Butterworth, Beena Akolkar, Jeffrey P. Krischer, Åke Lernmark, Marian Rewers, Jin-Xiong She, Jorma Toppari, Anette-Gabriele Ziegler, Aakrosh Ratan, Albert V. Smith, William A. Hagopian, Stephen S. Rich, Hemang M. Parikh, The TEDDY Study Group

Get full text

Accounting for population structure in genetic studies of cystic fibrosis by Hanley Kingston, Adrienne M. Stilp, William Gordon, Jai Broome, Stephanie M. Gogarten, Hua Ling, John Barnard, Shannon Dugan-Perez, Patrick T. Ellinor, Stacey Gabriel, Soren Germer, Richard A. Gibbs, Namrata Gupta, Kenneth Rice, Albert V. Smith, Michael C. Zody, Scott M. Blackman, Garry Cutting, Michael R. Knowles, Yi-Hui Zhou, Margaret Rosenfeld, Ronald L. Gibson, Michael Bamshad, Alison Fohner, Elizabeth E. Blue

Get full text

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. by Caroline S Fox, Yongmei Liu, Charles C White, Mary Feitosa, Albert V Smith, Nancy Heard-Costa, Kurt Lohman, GIANT Consortium, MAGIC Consortium, GLGC Consortium, Andrew D Johnson, Meredith C Foster, Danielle M Greenawalt, Paula Griffin, Jinghong Ding, Anne B Newman, Fran Tylavsky, Iva Miljkovic, Stephen B Kritchevsky, Lenore Launer, Melissa Garcia, Gudny Eiriksdottir, J Jeffrey Carr, Vilmunder Gudnason, Tamara B Harris, L Adrienne Cupples, Ingrid B Borecki

Get full text

The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels. by Elisabeth M van Leeuwen, Françoise A S Smouter, Tony Kam-Thong, Nazanin Karbalai, Albert V Smith, Tamara B Harris, Lenore J Launer, Colleen M Sitlani, Guo Li, Jennifer A Brody, Joshua C Bis, Charles C White, Alok Jaiswal, Ben A Oostra, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, Eric Boerwinkle, Christie M Ballantyne, Vilmundur Gudnason, Bruce M Psaty, L Adrienne Cupples, Marjo-Riitta Järvelin, Samuli Ripatti, Aaron Isaacs, Bertram Müller-Myhsok, Lennart C Karssen, Cornelia M van Duijn

Get full text

Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. by Yukinori Okada, Tomomitsu Hirota, Yoichiro Kamatani, Atsushi Takahashi, Hiroko Ohmiya, Natsuhiko Kumasaka, Koichiro Higasa, Yumi Yamaguchi-Kabata, Naoya Hosono, Michael A Nalls, Ming Huei Chen, Frank J A van Rooij, Albert V Smith, Toshiko Tanaka, David J Couper, Neil A Zakai, Luigi Ferrucci, Dan L Longo, Dena G Hernandez, Jacqueline C M Witteman, Tamara B Harris, Christopher J O'Donnell, Santhi K Ganesh, Koichi Matsuda, Tatsuhiko Tsunoda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Mayumi Tamari, Kazuhiko Yamamoto, Naoyuki Kamatani

Get full text

Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. by Megan L Grove, Bing Yu, Barbara J Cochran, Talin Haritunians, Joshua C Bis, Kent D Taylor, Mark Hansen, Ingrid B Borecki, L Adrienne Cupples, Myriam Fornage, Vilmundur Gudnason, Tamara B Harris, Sekar Kathiresan, Robert Kraaij, Lenore J Launer, Daniel Levy, Yongmei Liu, Thomas Mosley, Gina M Peloso, Bruce M Psaty, Stephen S Rich, Fernando Rivadeneira, David S Siscovick, Albert V Smith, Andre Uitterlinden, Cornelia M van Duijn, James G Wilson, Christopher J O'Donnell, Jerome I Rotter, Eric Boerwinkle

Get full text

Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium. by Faye L Norby, Samuel Adamsson Eryd, Maartje N Niemeijer, Lynda M Rose, Albert V Smith, Xiaoyan Yin, Sunil K Agarwal, Dan E Arking, Daniel L Chasman, Lin Y Chen, Mark Eijgelsheim, Gunnar Engström, Oscar H Franco, Jan Heeringa, George Hindy, Albert Hofman, Pamela L Lutsey, Jared W Magnani, David D McManus, Marju Orho-Melander, James S Pankow, Gull Rukh, Christina-Alexandra Schulz, André G Uitterlinden, Christine M Albert, Emelia J Benjamin, Vilmundur Gudnason, J Gustav Smith, Bruno H C Stricker, Alvaro Alonso

Get full text

Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program. by Chloé Sarnowski, Han Chen, Mary L Biggs, Sylvia Wassertheil-Smoller, Jan Bressler, Marguerite R Irvin, Kathleen A Ryan, David Karasik, Donna K Arnett, L Adrienne Cupples, David W Fardo, Stephanie M Gogarten, Benjamin D Heavner, Deepti Jain, Hyun Min Kang, Charles Kooperberg, Arch G Mainous, Braxton D Mitchell, Alanna C Morrison, Jeffrey R O'Connell, Bruce M Psaty, Kenneth Rice, Albert V Smith, Ramachandran S Vasan, B Gwen Windham, Douglas P Kiel, Joanne M Murabito, Kathryn L Lunetta, TOPMed Longevity and Healthy Aging Working Group, from the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

Get full text

Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes by Llilda Barata, Mary F. Feitosa, Lawrence F. Bielak, Brian Halligan, Abigail S. Baldridge, Xiuqing Guo, Laura M. Yerges‐Armstrong, Albert V. Smith, Jie Yao, Nicholette D. Palmer, Lisa B. VanWagner, J. Jeffrey Carr, Yii‐Der I. Chen, Matthew Allison, Matthew J. Budoff, Samuel K. Handelman, Sharon L.R. Kardia, Thomas H. Mosley Jr., Kathleen Ryan, Tamara B. Harris, Lenore J. Launer, Vilmundur Gudnason, Jerome I. Rotter, Myriam Fornage, Laura J. Rasmussen‐Torvik, Ingrid B. Borecki, Jeffrey R. O’Connell, Patricia A. Peyser, Elizabeth K. Speliotes, Michael A. Province

Get full text

Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. by Tamra E Meyer, Germaine C Verwoert, Shih-Jen Hwang, Nicole L Glazer, Albert V Smith, Frank J A van Rooij, Georg B Ehret, Eric Boerwinkle, Janine F Felix, Tennille S Leak, Tamara B Harris, Qiong Yang, Abbas Dehghan, Thor Aspelund, Ronit Katz, Georg Homuth, Thomas Kocher, Rainer Rettig, Janina S Ried, Christian Gieger, Hanna Prucha, Arne Pfeufer, Thomas Meitinger, Josef Coresh, Albert Hofman, Mark J Sarnak, Yii-Der Ida Chen, André G Uitterlinden, Aravinda Chakravarti, Bruce M Psaty, Cornelia M van Duijn, W H Linda Kao, Jacqueline C M Witteman, Vilmundur Gudnason, David S Siscovick, Caroline S Fox, Anna Köttgen, Genetic Factors for Osteoporosis Consortium, Meta Analysis of Glucose and Insulin Related Traits Consortium

Get full text

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. by Elizabeth K Speliotes, Laura M Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J Kim, Cameron D Palmer, Vilmundur Gudnason, Gudny Eiriksdottir, Melissa E Garcia, Lenore J Launer, Michael A Nalls, Jeanne M Clark, Braxton D Mitchell, Alan R Shuldiner, Johannah L Butler, Marta Tomas, Udo Hoffmann, Shih-Jen Hwang, Joseph M Massaro, Christopher J O'Donnell, Dushyant V Sahani, Veikko Salomaa, Eric E Schadt, Stephen M Schwartz, David S Siscovick, NASH CRN, GIANT Consortium, MAGIC Investigators, Benjamin F Voight, J Jeffrey Carr, Mary F Feitosa, Tamara B Harris, Caroline S Fox, Albert V Smith, W H Linda Kao, Joel N Hirschhorn, Ingrid B Borecki, GOLD Consortium

Get full text

Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function by Tianzhong Yang, Victoria E. Jackson, Albert V. Smith, Han Chen, Traci M. Bartz, Colleen M. Sitlani, Bruce M. Psaty, Sina A. Gharib, George T. O’Connor, Josée Dupuis, Jiayi Xu, Kurt Lohman, Yongmei Liu, Stephen B. Kritchevsky, Patricia A. Cassano, Claudia Flexeder, Christian Gieger, Stefan Karrasch, Annette Peters, Holger Schulz, Sarah E. Harris, John M. Starr, Ian J. Deary, Ani Manichaikul, Elizabeth C. Oelsner, R. G. Barr, Kent D. Taylor, Stephen S. Rich, Tobias N. Bonten, Dennis O. Mook-Kanamori, Raymond Noordam, Ruifang Li-Gao, Marjo-Riitta Jarvelin, Matthias Wielscher, Natalie Terzikhan, Lies Lahousse, Guy Brusselle, Stefan Weiss, Ralf Ewert, Sven Gläser, Georg Homuth, Nick Shrine, Ian P. Hall, Martin Tobin, Stephanie J. London, Peng Wei, Alanna C. Morrison

Get full text

Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. by Elizabeth G Holliday, Albert V Smith, Belinda K Cornes, Gabriëlle H S Buitendijk, Richard A Jensen, Xueling Sim, Thor Aspelund, Tin Aung, Paul N Baird, Eric Boerwinkle, Ching Yu Cheng, Cornelia M van Duijn, Gudny Eiriksdottir, Vilmundur Gudnason, Tamara Harris, Alex W Hewitt, Michael Inouye, Fridbert Jonasson, Barbara E K Klein, Lenore Launer, Xiaohui Li, Gerald Liew, Thomas Lumley, Patrick McElduff, Barbara McKnight, Paul Mitchell, Bruce M Psaty, Elena Rochtchina, Jerome I Rotter, Rodney J Scott, Wanting Tay, Kent Taylor, Yik Ying Teo, André G Uitterlinden, Ananth Viswanathan, Sophia Xie, Wellcome Trust Case Control Consortium 2, Johannes R Vingerling, Caroline C W Klaver, E Shyong Tai, David Siscovick, Ronald Klein, Mary Frances Cotch, Tien Y Wong, John Attia, Jie Jin Wang

Get full text

Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose. by Peitao Wu, Denis Rybin, Lawrence F Bielak, Mary F Feitosa, Nora Franceschini, Yize Li, Yingchang Lu, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sridharan Raghavan, Lynda M Rose, Karen Schwander, Albert V Smith, Salman M Tajuddin, Dina Vojinovic, Najaf Amin, Donna K Arnett, Erwin P Bottinger, Ayse Demirkan, Jose C Florez, Mohsen Ghanbari, Tamara B Harris, Lenore J Launer, Jingmin Liu, Jun Liu, Dennis O Mook-Kanamori, Alison D Murray, Mike A Nalls, Patricia A Peyser, André G Uitterlinden, Trudy Voortman, Claude Bouchard, Daniel Chasman, Adolfo Correa, Renée de Mutsert, Michele K Evans, Vilmundur Gudnason, Caroline Hayward, Linda Kao, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, Michael M Province, Tuomo Rankinen, Susan Redline, Paul M Ridker, Jerome I Rotter, David Siscovick, Blair H Smith, Cornelia van Duijn, Alan B Zonderman, D C Rao, James G Wilson, Josée Dupuis, James B Meigs, Ching-Ti Liu, Jason L Vassy

Get full text

Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program by Nicole D. Armstrong, Vinodh Srinivasasainagendra, Farah Ammous, Farah Ammous, Themistocles L. Assimes, Amber L. Beitelshees, Jennifer Brody, Brian E. Cade, Yii-Der Ida Chen, Han Chen, Han Chen, Paul S. de Vries, James S. Floyd, James S. Floyd, Nora Franceschini, Xiuqing Guo, Jacklyn N. Hellwege, Jacklyn N. Hellwege, John S. House, Chii-Min Hwu, Sharon L. R. Kardia, Ethan M. Lange, Leslie A. Lange, Caitrin W. McDonough, May E. Montasser, Jeffrey R. O’Connell, Megan M. Shuey, Megan M. Shuey, Xiao Sun, Rikki M. Tanner, Zhe Wang, Wei Zhao, Wei Zhao, April P. Carson, Todd L. Edwards, Todd L. Edwards, Tanika N. Kelly, Eimear E. Kenny, Charles Kooperberg, Ruth J. F. Loos, Alanna C. Morrison, Alison Motsinger-Reif, Bruce M. Psaty, Bruce M. Psaty, Bruce M. Psaty, Dabeeru C. Rao, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Jennifer A. Smith, Albert V. Smith, Marguerite R. Irvin, Donna K. Arnett

Get full text

Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants by Kristin L. Young, Virginia Fisher, Xuan Deng, Jennifer A. Brody, Misa Graff, Elise Lim, Bridget M. Lin, Hanfei Xu, Najaf Amin, Ping An, Stella Aslibekyan, Alison E. Fohner, Bertha Hidalgo, Petra Lenzini, Robert Kraaij, Carolina Medina-Gomez, Ivana Prokić, Fernando Rivadeneira, Colleen Sitlani, Ran Tao, Jeroen van Rooij, Di Zhang, Jai G. Broome, Erin J. Buth, Benjamin D. Heavner, Deepti Jain, Albert V. Smith, Kathleen Barnes, Meher Preethi Boorgula, Sameer Chavan, Dawood Darbar, Mariza De Andrade, Xiuqing Guo, Jeffrey Haessler, Marguerite R. Irvin, Rita R. Kalyani, Sharon L.R. Kardia, Charles Kooperberg, Wonji Kim, Rasika A. Mathias, Merry-Lynn McDonald, Braxton D. Mitchell, Patricia A. Peyser, Elizabeth A. Regan, Susan Redline, Alexander P. Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Scott Weiss, Kerri L. Wiggins, Lisa R. Yanek, Donna Arnett, Nancy L. Heard-Costa, Suzanne Leal, Danyu Lin, Barbara McKnight, Michael Province, Cornelia M. van Duijn, Kari E. North, L. Adrienne Cupples, Ching-Ti Liu

Get full text

Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program by Marsha M. Wheeler, Adrienne M. Stilp, Shuquan Rao, Bjarni V. Halldórsson, Doruk Beyter, Jia Wen, Anna V. Mihkaylova, Caitlin P. McHugh, John Lane, Min-Zhi Jiang, Laura M. Raffield, Goo Jun, Fritz J. Sedlazeck, Ginger Metcalf, Yao Yao, Joshua B. Bis, Nathalie Chami, Paul S. de Vries, Pinkal Desai, James S. Floyd, Yan Gao, Kai Kammers, Wonji Kim, Jee-Young Moon, Aakrosh Ratan, Lisa R. Yanek, Laura Almasy, Lewis C. Becker, John Blangero, Michael H. Cho, Joanne E. Curran, Myriam Fornage, Robert C. Kaplan, Joshua P. Lewis, Ruth J. F. Loos, Braxton D. Mitchell, Alanna C. Morrison, Michael Preuss, Bruce M. Psaty, Stephen S. Rich, Jerome I. Rotter, Hua Tang, Russell P. Tracy, Eric Boerwinkle, Goncalo R. Abecasis, Thomas W. Blackwell, Albert V. Smith, Andrew D. Johnson, Rasika A. Mathias, Deborah A. Nickerson, Matthew P. Conomos, Yun Li, Unnur Þorsteinsdóttir, Magnús K. Magnússon, Kari Stefansson, Nathan D. Pankratz, Daniel E. Bauer, Paul L. Auer, Alex P. Reiner

Get full text