ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex by Eleanor Williams, Elise Riesebos, Georgina Kerr, Alex N. Bullock

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Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12 by Zhuoyao Chen, Gregory A. Wasney, Sarah Picaud, Panagis Filippakopoulos, Masoud Vedadi, Vincenzo D'Angiolella, Alex N. Bullock

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Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva by Francesc Ventura, Eleanor Williams, Makoto Ikeya, Alex N. Bullock, Peter ten Dijke, Marie-José Goumans, Gonzalo Sanchez-Duffhues

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Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. by Alex N Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit E Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp

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CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function by Peter Canning, Kwangjin Park, João Gonçalves, Chunmei Li, Conor J. Howard, Timothy D. Sharpe, Liam J. Holt, Laurence Pelletier, Alex N. Bullock, Michel R. Leroux

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Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Sarac... by Bernard J. Smilde, Clemens Stockklausner, Richard Keen, Andrew Whittaker, Alex N. Bullock, Annette von Delft, Natasja M. van Schoor, Paul B. Yu, E. Marelise W. Eekhoff

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PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo by Elizabeth J. Brown, Leire Balaguer-Lluna, Adam P. Cribbs, Martin Philpott, Leticia Campo, Molly Browne, Jong Fu Wong, Udo Oppermann, Ángel M. Carcaboso, Alex N. Bullock, Gillian Farnie

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A new class of small molecule inhibitor of BMP signaling. by Caroline E Sanvitale, Georgina Kerr, Apirat Chaikuad, Marie-Christine Ramel, Agustin H Mohedas, Sabine Reichert, You Wang, James T Triffitt, Gregory D Cuny, Paul B Yu, Caroline S Hill, Alex N Bullock

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Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family by Olivier E. Nonga, Darja Lavogina, Erki Enkvist, Katrin Kestav, Apirat Chaikuad, Sarah E. Dixon-Clarke, Alex N. Bullock, Sergei Kopanchuk, Taavi Ivan, Ramesh Ekambaram, Kaido Viht, Stefan Knapp, Asko Uri

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Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1. by Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson

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Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva by Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie S. Place, Devaveena Dey, Yue Shen, Geoffrey A. Bocobo, Agustin H. Mohedas, Xiuli Huang, Philip E. Sanderson, Arthur Lee, Wei Zheng, Aris N. Economides, James C. Smith, Paul B. Yu, Alex N. Bullock

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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology by Anna Castano, Margaux Silvestre, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Han Wee Ong, Yi Lang, William Richardson, Josie A Silvaroli, Frances M Bashore, Jeffery L Smith, Isabelle M Genereux, Kelvin Dempster, David H Drewry, Navlot S Pabla, Alex N Bullock, Tim A Benke, Sila K Ultanir, Alison D Axtman

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Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel DiseaseSummary by Ahmad A. Al-Shaibi, Ussama M. Abdel-Motal, Satanay Z. Hubrack, Alex N. Bullock, Amna A. Al-Marri, Nourhen Agrebi, Abdulrahman A. Al-Subaiey, Nazira A. Ibrahim, Adrian K. Charles, Mamoun Elawad, Holm H. Uhlig, Bernice Lo, Saad R. Al-Kaabi, Muneera J. Al-Mohannadi, Fayaz A. Mir, Holm H. Uhlig, Simon P.L. Travis, Mamoun Elawad, Anthony K. Akobeng, Nazira A. Ibrahim, Fatma Al-Mudahka, Bernice Lo

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