ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 by Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev, Alexander Poltorak

Get full text

Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. by Colleen R McNamara, Ruchita Ahuja, Awo D Osafo-Addo, Douglas Barrows, Arminja Kettenbach, Igor Skidan, Xin Teng, Gregory D Cuny, Scott Gerber, Alexei Degterev

Get full text

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor by Tom Delanghe, Jon Huyghe, Seungheon Lee, Dario Priem, Samya Van Coillie, Barbara Gilbert, Sze Men Choi, Peter Vandenabeele, Alexei Degterev, Gregory D. Cuny, Yves Dondelinger, Mathieu J. M. Bertrand

Get full text

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation by Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak

Get full text

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1 by Malek Najjar, Chalada Suebsuwong, Soumya S. Ray, Roshan J. Thapa, Jenny L. Maki, Shoko Nogusa, Saumil Shah, Danish Saleh, Peter J. Gough, John Bertin, Junying Yuan, Siddharth Balachandran, Gregory D. Cuny, Alexei Degterev

Get full text

Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis by Limin Wu, Joon Yong Chung, Tian Cao, Gina Jin, William J. Edmiston, Suzanne Hickman, Emily S. Levy, Jordyn A. Whalen, Eliza Sophie LaRovere Abrams, Alexei Degterev, Eng H. Lo, Lorenzo Tozzi, David L. Kaplan, Joseph El Khoury, Michael J. Whalen

Get full text