SRC: A Century of Science Brought to the Clinic by Alexey Aleshin, Richard S. Finn

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25 Line of therapy adjustment in a patient with advanced triple-negative breast cancer (TNBC) by using personalized ctDNA test for treatment response monitoring by Georges Azzi, Shifra Krinshpun, Antony Tin, Allyson Malashevich, Meenakshi Malhotra, Paul Billings, Angel Rodriguez, Alexey Aleshin

ctDNA Clearance and Radiographic Resolution of Disease in Response to Dual Checkpoint Inhibition in Metastatic Microsatellite Stable Colorectal Cancer with a High Tumor Mutation B... by Charles J. Schneider, Michael Krainock, Allyson Koyen Malashevich, Meenakshi Malhotra, Perry Olshan, Paul R. Billings, Alexey Aleshin

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Early Detection of Circulating Tumor DNA Postoperatively Enables Discovery of Resectable Metastatic Disease in a Patient with Colon Cancer by Benjamin A. Weinberg, Emily R. Winslow, Mohammed Bayasi, Michael R. Krainock, Perry M. Olshan, Paul R. Billings, Alexey Aleshin

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Treatment Response Monitoring Using a Tumor-Informed Circulating Tumor DNA Test in an Advanced Triple-Negative Breast Cancer Patient: A Case Report by Georges Azzi, Shifra Krinshpun, Antony Tin, Minu Maninder, Allyson Koyen Malashevich, Meenakshi Malhotra, Ruben Ruiz Vega, Paul R. Billings, Angel Rodriguez, Alexey Aleshin

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Assessment of Molecular Residual Disease Using Circulating Tumor DNA to Identify Multiple Myeloma Patients at High Risk of Relapse by Binod Dhakal, Shruti Sharma, Mustafa Balcioglu, Svetlana Shchegrova, Meenakshi Malhotra, Bernhard Zimmermann, Paul R. Billings, Alexandra Harrington, Himanshu Sethi, Alexey Aleshin, Parameswaran N. Hari

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The Utility of Circulating Tumor DNA (ctDNA) Monitoring in Cancer Patients Who Are Pregnant or Planning to Become Pregnant by Stacey A. Cohen, Anup Kasi, Nicole Hook, Michael Krainock, Griffin Budde, Allyson Koyen Malashevich, Jeffrey Meltzer, Russ Jelsema, Perry Olshan, Paul R. Billings, Alexey Aleshin, Andrew S. Poklepovic

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Bespoke circulating tumor DNA as a biomarker for treatment response in a refractory Merkel cell carcinoma patient by John Yeakel, MD, Aarthi Kannan, BA, Nicole Hook Rattigan, PhD, Maki Yamamoto, MD, Alexey Aleshin, MD, MBA, Jeremy P. Harris, MPhil, MD, Ling Gao, MD, PhD

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BESPOKE IO protocol: a multicentre, prospective observational study evaluating the utility of ctDNA in guiding immunotherapy in patients with advanced solid tumours by Zeynep Eroglu, Joe Ensor, Meenakshi Malhotra, Paul Billings, Angel Rodriguez, Alexey Aleshin, Ling Gao, Sarah Sawyer, Pashtoon Murtaza Kasi, Sascha Ellers, George Ansstas, Michael Krainock, Sakti Chakrabarti, Andrew Poklepovic, Minu Maninder

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BESPOKE study protocol: a multicentre, prospective observational study to evaluate the impact of circulating tumour DNA guided therapy on patients with colorectal cancer by Scott Kopetz, Axel Grothey, Shifra Krinshpun, Meenakshi Malhotra, Paul Billings, Angel Rodriguez, Alexey Aleshin, Sarah Sawyer, Michelle Munro, Pashtoon Murtaza Kasi, Jessica Guilford, Sascha Ellers, Jacob Wulff, Nicole Hook, Allyson Koyen Malashevich, Solomon Moshkevich

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Early circulating tumor DNA dynamics as a pan‐tumor biomarker for long‐term clinical outcome in patients treated with durvalumab and tremelimumab by Maya Kansara, Neeru Bhardwaj, Subotheni Thavaneswaran, Chang Xu, Jessica K. Lee, Lo‐Bin Chang, Russell W. Madison, Frank Lin, Eugene Hsu, Vipul Kumar Patel, Alexey Aleshin, Geoffrey R. Oxnard, John Simes, Halla Nimeiri, David M. Thomas

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Circulating tumor DNA and magnetic resonance imaging to predict neoadjuvant chemotherapy response and recurrence risk by Mark Jesus M. Magbanua, Wen Li, Denise M. Wolf, Christina Yau, Gillian L. Hirst, Lamorna Brown Swigart, David C. Newitt, Jessica Gibbs, Amy L. Delson, Ekaterina Kalashnikova, Alexey Aleshin, Bernhard Zimmermann, A. Jo Chien, Debu Tripathy, Laura Esserman, Nola Hylton, Laura van ‘t Veer

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Correlation between variant allele frequency and mean tumor molecules with tumor burden in patients with solid tumors by Ekaterina Kalashnikova, Vasily N. Aushev, Allyson Koyen Malashevich, Antony Tin, Shifra Krinshpun, Raheleh Salari, Carly Bess Scalise, Rosalyn Ram, Meenakshi Malhotra, Harini Ravi, Himanshu Sethi, Stephanie Sanchez, Robert Tanner Hagelstrom, Maxim Brevnov, Matthew Rabinowitz, Solomon Moshkevich, Bernhard G. Zimmermann, Minetta C. Liu, Alexey Aleshin

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Molecular residual disease detection in resected, muscle-invasive urothelial cancer with a tissue-based comprehensive genomic profiling–informed personalized monitoring assay by Thomas Powles, Amanda Young, Halla Nimeiri, Russell W. Madison, Alexander Fine, Daniel R. Zollinger, Yanmei Huang, Chang Xu, Ole V. Gjoerup, Vasily N. Aushev, Hsin-Ta Wu, Alexey Aleshin, Corey Carter, Nicole Davarpanah, Viraj Degaonkar, Pratyush Gupta, Sanjeev Mariathasan, Erica Schleifman, Zoe June Assaf, Geoffrey Oxnard, Priti S. Hegde

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Adjuvant endocrine therapy with cyclin-dependent kinase 4/6 inhibitor, ribociclib, for localized hormone receptor-positive/HER2– breast cancer (LEADER) by Laura M. Spring, Lauren Scarpetti, Arielle J. Medford, Andrzej Niemierko, Amy Comander, Therese Mulvey, Lowell Schnipper, Steven J. Isakoff, Beverly Moy, Seth A. Wander, Jennifer Shin, Zanta Ephrem, Anneke R. Laposta, Elyssa Denault, Elizabeth Abraham, Gayle Calistro, Ekaterina Kalashnikova, Angel Rodriguez, Minetta C. Liu, Alexey Aleshin, Jeffrey Peppercorn, Leif W. Ellisen, Aditya Bardia

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Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity by S. Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek L. Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco A. J. Iafolla, Marc Oliva, Aaron R. Hansen, Anna Spreafico, Philippe L. Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K. Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G. Brooks, Tracy L. McGaha, Marcus O. Butler, Scott V. Bratman, Pamela S. Ohashi, Lillian L. Siu, Trevor J. Pugh

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ctDNA-based detection of molecular residual disease in stage I-III non-small cell lung cancer patients treated with definitive radiotherapy by Emily S. Lebow, Emily S. Lebow, Narek Shaverdian, Jordan E. Eichholz, Leah B. Kratochvil, Megan McCune, Yonina R. Murciano-Goroff, Yonina R. Murciano-Goroff, Justin Jee, Justin Jee, Juliana Eng, Juliana Eng, Jamie E. Chaft, Mark G. Kris, Mark G. Kris, Ekaterina Kalashnikova, Jordan Feeney, Carly Bess Scalise, Sumedha Sudhaman, Charuta C. Palsuledesai, Meenakshi Malhotra, Michael Krainock, Himanshu Sethi, Alexey Aleshin, Minetta C. Liu, Annemarie F. Shepherd, Abraham J. Wu, Charles B. Simone, Daphna Y. Gelblum, Kaylie A. Johnson, Charles M. Rudin, Charles M. Rudin, Daniel R. Gomez, Pedram Razavi, Pedram Razavi, Jorge S. Reis-Filho, James M. Isbell, James M. Isbell, Bob T. Li, Bob T. Li, Andreas Rimner

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