In Silico Multi-Target Approach Revealed Potential Lead Compounds as Scaffold for the Synthesis of Chemical Analogues Targeting SARS-CoV-2 by Alfonso Trezza, Claudia Mugnaini, Federico Corelli, Annalisa Santucci, Ottavia Spiga

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Molecular and Evolution <i>In Silico</i> Studies Unlock the h4-HPPD C-Terminal Tail Gating Mechanism by Alfonso Trezza, Ancuta Birgauan, Michela Geminiani, Anna Visibelli, Annalisa Santucci

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Unsupervised Learning in Precision Medicine: Unlocking Personalized Healthcare through AI by Alfonso Trezza, Anna Visibelli, Bianca Roncaglia, Ottavia Spiga, Annalisa Santucci

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HGA Triggers SAA Aggregation and Accelerates Fibril Formation in the C20/A4 Alkaptonuria Cell Model by Pierfrancesco Mastroeni, Alfonso Trezza, Michela Geminiani, Luisa Frusciante, Anna Visibelli, Annalisa Santucci

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Antioxidant Bio-Compounds from Chestnut Waste: A Value-Adding and Food Sustainability Strategy by Roberta Barletta, Alfonso Trezza, Andrea Bernini, Lia Millucci, Michela Geminiani, Annalisa Santucci

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Alkaptonuria: From Molecular Insights to a Dedicated Digital Platform by Maria Serena Milella, Michela Geminiani, Alfonso Trezza, Anna Visibelli, Daniela Braconi, Annalisa Santucci

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2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4<i>H</i>-chromen-2-yl)phenyl (<i>E</i>)-3-(4-hydroxy-3-methoxyphenyl)acrylate: Synthesis, In Silico Analysis and In Vitro Pharmacological Evalu... by Antonella Brizzi, Alfonso Trezza, Ottavia Spiga, Samuele Maramai, Francesco Scorzelli, Simona Saponara, Fabio Fusi

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From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel by Alfonso Trezza, Vittoria Cicaloni, Piera Porciatti, Andrea Langella, Fabio Fusi, Simona Saponara, Ottavia Spiga

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Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i> by Maria Lucia Schiavone, Roberta Barletta, Alfonso Trezza, Michela Geminiani, Lia Millucci, Natale Figura, Annalisa Santucci

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<i>Chaetomorpha linum</i> Extract as a Source of Antimicrobial Compounds: A Circular Bioeconomy Approach by Roberta Barletta, Alfonso Trezza, Michela Geminiani, Luisa Frusciante, Tommaso Olmastroni, Filomena Sannio, Jean-Denis Docquier, Annalisa Santucci

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Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste by Alfonso Trezza, Roberta Barletta, Michela Geminiani, Luisa Frusciante, Tommaso Olmastroni, Filomena Sannio, Jean-Denis Docquier, Annalisa Santucci

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Repurposing <i>Castanea sativa</i> Spiny Burr By-Products Extract as a Potentially Effective Anti-Inflammatory Agent for Novel Future Biotechnological Applications by Luisa Frusciante, Michela Geminiani, Tommaso Olmastroni, Pierfrancesco Mastroeni, Alfonso Trezza, Laura Salvini, Stefania Lamponi, Ottavia Spiga, Annalisa Santucci

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Integrated Clinomics and Molecular Dynamics Simulation Approaches Reveal the SAA1.1 Allele as a Biomarker in Alkaptonuria Disease Severity by Alfonso Trezza, Bianca Roncaglia, Anna Visibelli, Roberta Barletta, Luana Peruzzi, Barbara Marzocchi, Daniela Braconi, Ottavia Spiga, Annalisa Santucci

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The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells by Simona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Brian Hopkins, Margaret A. Brimble, David Rennison, Sergio Bova

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Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits Ca_V1.2 and Stimulates K_Ca1.1 Channels by Gabriele Carullo, Simona Saponara, Amer Ahmed, Beatrice Gorelli, Sarah Mazzotta, Alfonso Trezza, Beatrice Gianibbi, Giuseppe Campiani, Fabio Fusi, Francesca Aiello

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Phytochemical Composition, Anti-Inflammatory Property, and Anti-Atopic Effect of <i>Chaetomorpha linum</i> Extract by Luisa Frusciante, Michela Geminiani, Alfonso Trezza, Tommaso Olmastroni, Pierfrancesco Mastroeni, Laura Salvini, Stefania Lamponi, Andrea Bernini, Daniela Grasso, Elena Dreassi, Ottavia Spiga, Annalisa Santucci

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Vietnamese <i>Dalbergia tonkinensis</i>: A Promising Source of Mono- and Bifunctional Vasodilators by Nguyen Manh Cuong, Ninh The Son, Ngu Truong Nhan, Yoshiyasu Fukuyama, Amer Ahmed, Simona Saponara, Alfonso Trezza, Beatrice Gianibbi, Ginevra Vigni, Ottavia Spiga, Fabio Fusi

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Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease by Ottavia Spiga, Vittoria Cicaloni, Cosimo Fiorini, Alfonso Trezza, Anna Visibelli, Lia Millucci, Giulia Bernardini, Andrea Bernini, Barbara Marzocchi, Daniela Braconi, Filippo Prischi, Annalisa Santucci

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Exploring the Antioxidant and Anti-Inflammatory Potential of Saffron (<i>Crocus sativus</i>) Tepals Extract within the Circular Bioeconomy by Luisa Frusciante, Michela Geminiani, Behnaz Shabab, Tommaso Olmastroni, Giorgia Scavello, Martina Rossi, Pierfrancesco Mastroeni, Collins Nyaberi Nyong’a, Laura Salvini, Stefania Lamponi, Maria Laura Parisi, Adalgisa Sinicropi, Lorenzo Costa, Ottavia Spiga, Alfonso Trezza, Annalisa Santucci

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