Immune Checkpoint Inhibitors in pMMR Metastatic Colorectal Cancer: A Tough Challenge by Federica Marmorino, Alessandra Boccaccino, Marco Maria Germani, Alfredo Falcone, Chiara Cremolini

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Review: Beyond KRAS: perspectives on new potential markers of intrinsic and acquired resistance to epidermal growth factor receptor inhibitors in metastatic colorectal cancer by Fotios Loupakis, Chiara Cremolini, Gabriella Fontanini, Irene Stasi, Lisa Salvatore, Alfredo Falcone

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KRAS early testing: consensus initiative and cost-effectiveness evaluation for metastatic colorectal patients in an Italian setting. by Carlo Barone, Carmine Pinto, Nicola Normanno, Lorenzo Capussotti, Francesco Cognetti, Alfredo Falcone, Lorenzo Mantovani

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Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation. by Lorenzo Fornaro, Caterina Vivaldi, Dong Lin, Hui Xue, Alfredo Falcone, Yuzhuo Wang, Francesco Crea, Martin D Bootman

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Real-world treatment patterns, healthcare resource use and clinical outcomes of patients receiving second line therapy for advanced or metastatic gastric cancer by David Gómez-Ulloa, Mayur Amonkar, Smita Kothari, Winson Y. Cheung, Ian Chau, John R. Zalcberg, Núria Lara Suriñach, Alfredo Falcone

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Early changes in plasma DNA levels of mutant KRAS as a sensitive marker of response to chemotherapy in pancreatic cancer by Marzia Del Re, Caterina Vivaldi, Eleonora Rofi, Enrico Vasile, Mario Miccoli, Chiara Caparello, Paolo Davide d’Arienzo, Lorenzo Fornaro, Alfredo Falcone, Romano Danesi

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Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN) by Lorenzo Fornaro, Andrea Spallanzani, Ferdinando de Vita, Domenico D’Ugo, Alfredo Falcone, Laura Lorenzon, Giuseppe Tirino, Stefano Cascinu, on behalf of GAIN (GAstric Cancer Italian Network)

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A Model of a Zebrafish Avatar for Co-Clinical Trials by Alice Usai, Gregorio Di Franco, Patrizia Colucci, Luca Emanuele Pollina, Enrico Vasile, Niccola Funel, Matteo Palmeri, Luciana Dente, Alfredo Falcone, Luca Morelli, Vittoria Raffa

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Role of Baseline Computed-Tomography-Evaluated Body Composition in Predicting Outcome and Toxicity from First-Line Therapy in Advanced Gastric Cancer Patients by Silvia Catanese, Giacomo Aringhieri, Caterina Vivaldi, Francesca Salani, Saverio Vitali, Irene Pecora, Valentina Massa, Monica Lencioni, Enrico Vasile, Rachele Tintori, Francesco Balducci, Alfredo Falcone, Carla Cappelli, Lorenzo Fornaro

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Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients by Nico B. Volz, Diana L. Hanna, Sebastian Stintzing, Wu Zhang, Dongyun Yang, Shu Cao, Yan Ning, Satoshi Matsusaka, Yu Sunakawa, Martin D. Berger, Chiara Cremolini, Fotios Loupakis, Alfredo Falcone, Heinz-Josef Lenz

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Zebrafish Patient-Derived Xenografts Identify Chemo-Response in Pancreatic Ductal Adenocarcinoma Patients by Alice Usai, Gregorio Di Franco, Margherita Piccardi, Perla Cateni, Luca Emanuele Pollina, Caterina Vivaldi, Enrico Vasile, Niccola Funel, Matteo Palmeri, Luciana Dente, Alfredo Falcone, Dimitri Giunchi, Alessandro Massolo, Vittoria Raffa, Luca Morelli

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Impact of genetic variants involved in the lipid metabolism pathway on progression free survival in patients receiving bevacizumab-based chemotherapy in metastatic colorectal cance... by Jingyuan Wang, Joshua Millstein, Yan Yang, Sebastian Stintzing, Hiroyuki Arai, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Christoph Mancao, Chiara Cremolini, Tianshu Liu, Volker Heinemann, Alfredo Falcone, Lin Shen, Heinz-Josef Lenz

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Safety, efficacy and patient-reported outcomes with trifluridine/tipiracil in pretreated metastatic colorectal cancer: results of the PRECONNECT study by Timothy Price, Chiara Cremolini, Alfredo Falcone, Eric Van Cutsem, Julien Taieb, Jean-Marc Phelip, Jean-Baptiste Bachet, Lucjan Wyrwicz, Fabienne Portales, Ahmet Ozet, Irfan Cicin, Dan Atlan, Martin Becquart, Loick Vidot, Nadjat Mounedji

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Single Nucleotide Polymorphisms in MiRNA Binding Sites of Nucleotide Excision Repair-Related Genes Predict Clinical Benefit of Oxaliplatin in FOLFOXIRI Plus Bevacizumab: Analysis o... by Mitsukuni Suenaga, Marta Schirripa, Shu Cao, Wu Zhang, Dongyun Yang, Chiara Cremolini, Sabina Murgioni, Sara Lonardi, Yan Ning, Satoshi Okazaki, Martin D. Berger, Yuji Miyamoto, Afsaneh Barzi, Fotios Loupakis, Alfredo Falcone, Heinz-Josef Lenz

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The Role of Anti-Angiogenics in Pre-Treated Metastatic <i>BRAF</i>-Mutant Colorectal Cancer: A Pooled Analysis by Fabio Gelsomino, Andrea Casadei-Gardini, Daniele Rossini, Alessandra Boccaccino, Gianluca Masi, Chiara Cremolini, Andrea Spallanzani, Massimo Giuseppe Viola, Ingrid Garajovà, Massimiliano Salati, Maria Teresa Elia, Francesco Caputo, Chiara Santini, Alfredo Falcone, Stefano Cascinu, Emiliano Tamburini

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High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer. by Elisa Giovannetti, Arjan van der Velde, Niccola Funel, Enrico Vasile, Vittorio Perrone, Leticia G Leon, Nelide De Lio, Amir Avan, Sara Caponi, Luca E Pollina, Valentina Gallá, Hiroko Sudo, Alfredo Falcone, Daniela Campani, Ugo Boggi, Godefridus J Peters

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Early Tumor Shrinkage and Depth of Response Evaluation in Metastatic Pancreatic Cancer Treated with First Line Chemotherapy: An Observational Retrospective Cohort Study by Caterina Vivaldi, Lorenzo Fornaro, Carla Cappelli, Irene Pecora, Silvia Catanese, Francesca Salani, Andrea Cacciato Insilla, Emanuele Kauffmann, Francescamaria Donati, Giulia Pasquini, Valentina Massa, Niccolò Napoli, Monica Lencioni, Piero Boraschi, Daniela Campani, Ugo Boggi, Davide Caramella, Alfredo Falcone, Enrico Vasile

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Correction: Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case by Matteo Fassan, Chiara Cremolini, Matteo Benelli, Elisa Fontana, Filippo Pagani, Daniele Rossini, Giovanni Fucà, Adele Busico, Elena Conca, Samantha Di Donato, Fotios Loupakis, Marta Schirripa, Sara Lonardi, Beatrice Borelli, Elena Ongaro, Katherine Eason, Mariaelena Casagrande, Anguraj Sadanandam, Filippo de Braud, Alfredo Falcone

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Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab. by Fotios Loupakis, Chiara Cremolini, Dongyun Yang, Lisa Salvatore, Wu Zhang, Takeru Wakatsuki, Pierre Bohanes, Marta Schirripa, Leonor Benhaim, Sara Lonardi, Carlotta Antoniotti, Giuseppe Aprile, Francesco Graziano, Annamaria Ruzzo, Sara Lucchesi, Monica Ronzoni, Ferdinando De Vita, Giuseppe Tonini, Alfredo Falcone, Heinz-Josef Lenz

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NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients. by Marta Schirripa, Wu Zhang, Dongyun Yang, Shu Cao, Satoshi Okazaki, Fotios Loupakis, Martin D Berger, Yan Ning, Yuji Miyamoto, Mitsukuni Suenaga, Giulia Alberti, Jordan D West, Sara Lonardi, Taline Khoukaz, Francesca Bergamo, Francesca Battaglin, Carlotta Antoniotti, Alfredo Falcone, Sebastian Stintzing, Volker Heinemann, Heinz-Josef Lenz

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