Chimpanzee adenoviral vectors as vaccines – challenges to move the technology into the fast lane by Alessandra Vitelli, Antonella Folgori, Elisa Scarselli, Stefano Colloca, Stefania Capone, Alfredo Nicosia

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Adenovirus Encoded Adjuvant (AdEnA) anti-CTLA-4, a novel strategy to improve Adenovirus based vaccines against infectious diseases and cancer by Anna Morena D’Alise, Linda Nocchi, Irene Garzia, Laura Seclì, Luigia Infante, Fulvia Troise, Gabriella Cotugno, Simona Allocca, Giuseppina Romano, Armin Lahm, Guido Leoni, Emanuele Sasso, Emanuele Sasso, Elisa Scarselli, Alfredo Nicosia, Alfredo Nicosia

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A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection by Felicity Hartnell, Anthony Brown, Stefania Capone, Jakub Kopycinski, Carly Bliss, Shokouh Makvandi-Nejad, Leo Swadling, Emma Ghaffari, Paola Cicconi, Mariarosaria Del Sorbo, Roberta Sbrocchi, Ilaria Esposito, Ventzislav Vassilev, Paula Marriott, Clair M. Gardiner, Ciaran Bannan, Colm Bergin, Matthias Hoffmann, Bethany Turner, Alfredo Nicosia, Alfredo Nicosia, Alfredo Nicosia, Antonella Folgori, Tomáš Hanke, Tomáš Hanke, Eleanor Barnes, Eleanor Barnes, Lucy Dorrell, Lucy Dorrell

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High-Throughput Monoclonal Antibody Discovery from Phage Libraries: Challenging the Current Preclinical Pipeline to Keep the Pace with the Increasing mAb Demand by Nicola Zambrano, Guendalina Froechlich, Dejan Lazarevic, Margherita Passariello, Alfredo Nicosia, Claudia De Lorenzo, Marco J. Morelli, Emanuele Sasso

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Novel Human Anti-PD-L1 mAbs Inhibit Immune-Independent Tumor Cell Growth and PD-L1 Associated Intracellular Signalling by Margherita Passariello, Anna Morena D’Alise, Annachiara Esposito, Cinzia Vetrei, Guendalina Froechlich, Elisa Scarselli, Alfredo Nicosia, Claudia De Lorenzo

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Safety and Immunogenicity of Malaria Vectored Vaccines Given with Routine Expanded Program on Immunization Vaccines in Gambian Infants and Neonates: A Randomized Controlled Trial by Victorine A. Mensah, Sophie Roetynck, Ebrima K. Kanteh, Georgina Bowyer, Amy Ndaw, Francis Oko, Carly M. Bliss, Ya Jankey Jagne, Riccardo Cortese, Alfredo Nicosia, Alfredo Nicosia, Alfredo Nicosia, Rachel Roberts, Flavia D’Alessio, Odile Leroy, Babacar Faye, Beate Kampmann, Beate Kampmann, Badara Cisse, Kalifa Bojang, Stephen Gerry, Nicola K. Viebig, Alison M. Lawrie, Ed Clarke, Egeruan B. Imoukhuede, Katie J. Ewer, Adrian V. S. Hill, Adrian V. S. Hill, Muhammed O. Afolabi

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Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature by Ambra Natalini, Sonia Simonetti, Gabriele Favaretto, Lorenzo Lucantonio, Lorenzo Lucantonio, Giovanna Peruzzi, Miguel Muñoz-Ruiz, Gavin Kelly, Alessandra M. Contino, Roberta Sbrocchi, Simone Battella, Stefania Capone, Antonella Folgori, Alfredo Nicosia, Alfredo Nicosia, Angela Santoni, Adrian C. Hayday, Adrian C. Hayday, Adrian C. Hayday, Francesca Di Rosa

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Corrigendum: Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature by Ambra Natalini, Sonia Simonetti, Gabriele Favaretto, Lorenzo Lucantonio, Lorenzo Lucantonio, Giovanna Peruzzi, Miguel Muñoz-Ruiz, Gavin Kelly, Alessandra M. Contino, Roberta Sbrocchi, Simone Battella, Stefania Capone, Antonella Folgori, Alfredo Nicosia, Alfredo Nicosia, Angela Santoni, Adrian C. Hayday, Adrian C. Hayday, Adrian C. Hayday, Francesca Di Rosa

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Generation of a Retargeted Oncolytic <i>Herpes</i> Virus Encoding Adenosine Deaminase for Tumor Adenosine Clearance by Chiara Gentile, Arianna Finizio, Guendalina Froechlich, Anna Morena D’Alise, Gabriella Cotugno, Sara Amiranda, Alfredo Nicosia, Elisa Scarselli, Nicola Zambrano, Emanuele Sasso

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Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells by Margherita Passariello, Cinzia Vetrei, Emanuele Sasso, Guendalina Froechlich, Chiara Gentile, Anna Morena D'Alise, Nicola Zambrano, Elisa Scarselli, Alfredo Nicosia, Claudia De Lorenzo

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Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain. by Alexandra J Spencer, Matthew G Cottingham, Jennifer A Jenks, Rhea J Longley, Stefania Capone, Stefano Colloca, Antonella Folgori, Riccardo Cortese, Alfredo Nicosia, Migena Bregu, Adrian V S Hill

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Generation of a Novel Mesothelin-Targeted Oncolytic <i>Herpes</i> Virus and Implemented Strategies for Manufacturing by Guendalina Froechlich, Chiara Gentile, Luigia Infante, Carmen Caiazza, Pasqualina Pagano, Sarah Scatigna, Gabriella Cotugno, Anna Morena D’Alise, Armin Lahm, Elisa Scarselli, Alfredo Nicosia, Massimo Mallardo, Emanuele Sasso, Nicola Zambrano

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Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of <i>Herpes Simplex</i> Oncolytic Virus by Guendalina Froechlich, Carmen Caiazza, Chiara Gentile, Anna Morena D’Alise, Maria De Lucia, Francesca Langone, Guido Leoni, Gabriella Cotugno, Vittorio Scisciola, Alfredo Nicosia, Elisa Scarselli, Massimo Mallardo, Emanuele Sasso, Nicola Zambrano

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Vaccination to conserved influenza antigens in mice using a novel Simian adenovirus vector, PanAd3, derived from the bonobo Pan paniscus. by Alessandra Vitelli, Mary R Quirion, Chia-Yun Lo, Julia A Misplon, Agnieszka K Grabowska, Angiolo Pierantoni, Virginia Ammendola, Graeme E Price, Mark R Soboleski, Riccardo Cortese, Stefano Colloca, Alfredo Nicosia, Suzanne L Epstein

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A phase Ia study to assess the safety and immunogenicity of new malaria vaccine candidates ChAd63 CS administered alone and with MVA CS. by Eoghan de Barra, Susanne H Hodgson, Katie J Ewer, Carly M Bliss, Kerrie Hennigan, Ann Collins, Eleanor Berrie, Alison M Lawrie, Sarah C Gilbert, Alfredo Nicosia, Samuel J McConkey, Adrian V S Hill

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VENUS, a Novel Selection Approach to Improve the Accuracy of Neoantigens’ Prediction by Guido Leoni, Anna Morena D’Alise, Fabio Giovanni Tucci, Elisa Micarelli, Irene Garzia, Maria De Lucia, Francesca Langone, Linda Nocchi, Gabriella Cotugno, Rosa Bartolomeo, Giuseppina Romano, Simona Allocca, Fulvia Troise, Alfredo Nicosia, Armin Lahm, Elisa Scarselli

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Retargeted and Multi-cytokine-Armed Herpes Virus Is a Potent Cancer Endovaccine for Local and Systemic Anti-tumor Treatment by Maria De Lucia, Gabriella Cotugno, Veronica Bignone, Irene Garzia, Linda Nocchi, Francesca Langone, Biljana Petrovic, Emanuele Sasso, Simona Pepe, Guendalina Froechlich, Chiara Gentile, Nicola Zambrano, Gabriella Campadelli-Fiume, Alfredo Nicosia, Elisa Scarselli, Anna Morena D’Alise

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Mucosal Vaccination with Heterologous Viral Vectored Vaccine Targeting Subdominant SIV Accessory Antigens Strongly Inhibits Early Viral Replication by Huanbin Xu, Anne-Marie Andersson, Emeline Ragonnaud, Ditte Boilesen, Anders Tolver, Benjamin Anderschou Holbech Jensen, James L. Blanchard, Alfredo Nicosia, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Allan Randrup Thomsen, Jan Pravsgaard Christensen, Ronald S. Veazey, Peter Johannes Holst

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Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion by Jonathan Zalevsky, Deborah H Charych, Alfredo Nicosia, Fulvia Troise, Anna Morena D'Alise, Guido Leoni, Maria De Lucia, Francesca Langone, Linda Nocchi, Fabio Giovanni Tucci, Elisa Micarelli, Gabriella Cotugno, Irene Garzia, Rosa Vitale, Veronica Bignone, Elena Di Matteo, Rosa Bartolomeo, Armin Lahm, Elisa Scarselli

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Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection by Leo Swadling, John Halliday, Christabel Kelly, Anthony Brown, Stefania Capone, M. Azim Ansari, David Bonsall, Rachel Richardson, Felicity Hartnell, Jane Collier, Virginia Ammendola, Mariarosaria Del Sorbo, Annette Von Delft, Cinzia Traboni, Adrian V. S. Hill, Stefano Colloca, Alfredo Nicosia, Riccardo Cortese, Paul Klenerman, Antonella Folgori, Eleanor Barnes

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