RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives by Dana Alawieh, Leila Cysique-Foinlan, Christophe Willekens, Aline Renneville

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Acute myeloid leukemia with translocation t(3;5): new molecular insights by Florent Dumézy, Aline Renneville, Caroline Mayeur-Rousse, Olivier Nibourel, Elise Labis, Claude Preudhomme

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Slow relapse in acute myeloid leukemia with inv(16) or t(16;16) by Thomas Clozel, Aline Renneville, Marion Venot, Claude Gardin, Charikleia Kelaidi, Geneviève Leroux, Virginie Eclache, Claude Preudhomme, Pierre Fenaux, Lionel Adès

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Linezolid induces ring sideroblasts by Christophe Willekens, Florent Dumezy, Thomas Boyer, Aline Renneville, Julien Rossignol, Céline Berthon, Angélique Cotteau-Leroy, Lotfi Mehiaoui, Bruno Quesnel, Claude Preudhomme

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Acute lymphoblastic leukemia in patients treated with lenalidomide for multiple myeloma: a safety meta-analysis of randomized controlled trials combined with a retrospective study... by Pierre-Marie Morice, Sabine Khalife-Hachem, Marion Sassier, Véronique Lelong-Boulouard, Alina Danu, Florence Pasquier, Aline Renneville, Charles Dolladille, Jean-Baptiste Micol

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Prospective long-term minimal residual disease monitoring using RQ-PCR in RUNX1-RUNX1T1-positive acute myeloid leukemia: results of the French CBF-2006 trial by Christophe Willekens, Odile Blanchet, Aline Renneville, Pascale Cornillet-Lefebvre, Cécile Pautas, Romain Guieze, Norbert Ifrah, Hervé Dombret, Eric Jourdan, Claude Preudhomme, Nicolas Boissel

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Germ-line GATA2 p.THR354MET mutation in familial myelodysplastic syndrome with acquired monosomy 7 and ASXL1 mutation demonstrating rapid onset and poor survival by Csaba Bödör, Aline Renneville, Matthew Smith, Aurélie Charazac, Sameena Iqbal, Pascaline Étancelin, Jamie Cavenagh, Michael J Barnett, Karolina Kramarzová, Biju Krishnan, András Matolcsy, Claude Preudhomme, Jude Fitzgibbon, Carolyn Owen

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Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. A study by the French ALFA group by Yann Ferret, Nicolas Boissel, Nathalie Helevaut, Jordan Madic, Olivier Nibourel, Alice Marceau-Renaut, Maxime Bucci, Sandrine Geffroy, Karine Celli-Lebras, Sylvie Castaigne, Xavier Thomas, Christine Terré, Hervé Dombret, Claude Preudhomme, Aline Renneville

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High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia. by Sandrine Hayette, Xavier Thomas, Laurent Jallades, Kaddour Chabane, Carole Charlot, Isabelle Tigaud, Sophie Gazzo, Stéphane Morisset, Pascale Cornillet-Lefebvre, Adriana Plesa, Sarah Huet, Aline Renneville, Gilles Salles, Franck Emmanuel Nicolini, Jean-Pierre Magaud, Mauricette Michallet

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Impact of additional genetic alterations on the outcome of patients with NPM1-mutated cytogenetically normal acute myeloid leukemia by Pierre Peterlin, Aline Renneville, Raouf Ben Abdelali, Olivier Nibourel, Xavier Thomas, Cécile Pautas, Stéphane de Botton, Emmanuel Raffoux, Jean-Michel Cayuela, Nicolas Boissel, Christine Terré, Karine Celli-Lebras, Sylvie Castaigne, Claude Preudhomme, Claude Gardin, Hervé Dombret

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Targeting heterochromatin eliminates chronic myelomonocytic leukemia malignant stem cells through reactivation of retroelements and immune pathways by Donia Hidaoui, Audrey Porquet, Rabie Chelbi, Mathieu Bohm, Aikaterini Polyzou, Vincent Alcazer, Stéphane Depil, Aygun Imanci, Margot Morabito, Aline Renneville, Dorothée Selimoglu-Buet, Sylvain Thépot, Raphael Itzykson, Lucie Laplane, Nathalie Droin, Eirini Trompouki, Emilie Elvira-Matelot, Eric Solary, Françoise Porteu

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Prognostic Role of Gene Mutations in Chronic Myelomonocytic Leukemia Patients Treated With Hypomethylating Agents by Matthieu Duchmann, Fevzi F. Yalniz, Alessandro Sanna, David Sallman, Catherine C. Coombs, Aline Renneville, Olivier Kosmider, Thorsten Braun, Uwe Platzbecker, Lise Willems, Lionel Adès, Michaela Fontenay, Raajit Rampal, Eric Padron, Nathalie Droin, Claude Preudhomme, Valeria Santini, Mrinal M. Patnaik, Pierre Fenaux, Eric Solary, Raphael Itzykson

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Dasatinib in high-risk core binding factor acute myeloid leukemia in first complete remission: a French Acute Myeloid Leukemia Intergroup trial by Nicolas Boissel, Aline Renneville, Thibaut Leguay, Pascale Cornillet Lefebvre, Christian Recher, Thibaud Lecerf, Eric Delabesse, Céline Berthon, Odile Blanchet, Thomas Prebet, Cécile Pautas, Patrice Chevallier, Stéphane Leprêtre, Stéphane Girault, Caroline Bonmati, Romain Guièze, Chantal Himberlin, Edouard Randriamalala, Claude Preudhomme, Eric Jourdan, Hervé Dombret, Norbert Ifrah

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When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes by Christophe Willekens, Claude Chahine, Matteo Dragani, Sabine Khalife‐Hachem, Camille Bigenwald, Julien Rossignol, Cristina Castilla‐Llorente, Alina Danu, Jean‐Marie Michot, Veronique Saada, Sophie Cotteret, Christophe Marzac, Aline Renneville, Isabelle Plo, Sophie Broutin, Nelly Bosselut, Bruno Cassinat, Julien Lazarovici, Nathalie Droin, Stephane De Botton

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Molecular Landscape of Therapy-related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers by Sabine Khalife-Hachem, Khalil Saleh, Florence Pasquier, Christophe Willekens, Anthony Tarabay, Leony Antoun, Thomas Grinda, Cristina Castilla-Llorente, Matthieu Duchmann, Cyril Quivoron, Nathalie Auger, Veronique Saada, Suzette Delaloge, Alexandra Leary, Aline Renneville, Ileana Antony-Debre, Filippo Rosselli, Stéphane De Botton, Flore Salviat, Christophe Marzac, Jean-Baptiste Micol

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1510 Multiomic functional biomarkers for cancer prediction and early detection by Hui Chen, Laurence Zitvogel, Guido Kroemer, Lisa Derosa, Suzette Delaloge, Olivier Caron, Sylvere Durand, Damien Drubay, Marine Fidelle, Carolina Alves Costa Silva, Aymeric Silvin, David Boulate, Olaf Mercier, Deborah Suissa, Roxanne Birebent, Tarek Ben-Ahmed, Anne-Laure Mallard de la Varende, Quentin Blampey, Charles-Antoine Dutertre, Aline Renneville

A phase II study of guadecitabine in higher-risk myelodysplastic syndrome and low blast count acute myeloid leukemia after azacitidine failure by Marie Sébert, Aline Renneville, Cécile Bally, Pierre Peterlin, Odile Beyne-Rauzy, Laurence Legros, Marie-Pierre Gourin, Laurence Sanhes, Eric Wattel, Emmanuel Gyan, Sophie Park, Aspasia Stamatoullas, Anne Banos, Kamel Laribi, Simone Jueliger, Luke Bevan, Fatiha Chermat, Rosa Sapena, Olivier Nibourel, Cendrine Chaffaut, Sylvie Chevret, Claude Preudhomme, Lionel Adès, Pierre Fenaux

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A randomized phase II trial of azacitidine +/− epoetin-β in lower-risk myelodysplastic syndromes resistant to erythropoietic stimulating agents by Sylvain Thépot, Raouf Ben Abdelali, Sylvie Chevret, Aline Renneville, Odile Beyne-Rauzy, Thomas Prébet, Sophie Park, Aspasia Stamatoullas, Agnes Guerci-Bresler, Stéphane Cheze, Gérard Tertian, Bachra Choufi, Laurence Legros, Jean Noel Bastié, Jacques Delaunay, Marie Pierre Chaury, Laurence Sanhes, Eric Wattel, Francois Dreyfus, Norbert Vey, Fatiha Chermat, Claude Preudhomme, Pierre Fenaux, Claude Gardin

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The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants by Ana Rio-Machin, Tom Vulliamy, Nele Hug, Amanda Walne, Kiran Tawana, Shirleny Cardoso, Alicia Ellison, Nikolas Pontikos, Jun Wang, Hemanth Tummala, Ahad Fahad H. Al Seraihi, Jenna Alnajar, Findlay Bewicke-Copley, Hannah Armes, Michael Barnett, Adrian Bloor, Csaba Bödör, David Bowen, Pierre Fenaux, Andrew Green, Andrew Hallahan, Henrik Hjorth-Hansen, Upal Hossain, Sally Killick, Sarah Lawson, Mark Layton, Alison M. Male, Judith Marsh, Priyanka Mehta, Rogier Mous, Josep F. Nomdedéu, Carolyn Owen, Jiri Pavlu, Elspeth M. Payne, Rachel E. Protheroe, Claude Preudhomme, Nuria Pujol-Moix, Aline Renneville, Nigel Russell, Anand Saggar, Gabriela Sciuccati, David Taussig, Cynthia L. Toze, Anne Uyttebroeck, Peter Vandenberghe, Brigitte Schlegelberger, Tim Ripperger, Doris Steinemann, John Wu, Joanne Mason, Paula Page, Susanna Akiki, Kim Reay, Jamie D. Cavenagh, Vincent Plagnol, Javier F. Caceres, Jude Fitzgibbon, Inderjeet Dokal

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