Alison Goate

Alison Mary Goate is the Jean C. and James W. Crystal Professor and Chair of the Department of Genetics and Genomic Sciences and Director of the Loeb Center for Alzheimer's Disease at Icahn School of Medicine at Mount Sinai, New York City. She was previously professor of genetics in psychiatry, professor of genetics, and professor of neurology at Washington University School of Medicine.

The Goate Lab studies the genetics and molecular bases of Alzheimer's disease, frontotemporal dementia, and alcoholism. Provided by Wikipedia
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  1. 1
    Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

    Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes by Jun Wang, Anne L Brunkan, Silva Hecimovic, Emily Walker, Alison Goate

    Published 2004-04-01
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  2. 2
    CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes.

    CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common ami... by A Joseph Bloom, Maribel Martinez, Li-Shiun Chen, Laura J Bierut, Sharon E Murphy, Alison Goate

    Published 2013-01-01
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  3. 3
    Autosomal Dominant Alzheimer’s Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice

    Autosomal Dominant Alzheimer’s Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice by Carmen Romero-Molina, Sarah M. Neuner, Marcelina Ryszawiec, Alice Pébay, Dominantly Inherited Alzheimer Network, Edoardo Marcora, Alison Goate

    Published 2024-02-01
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  4. 4
    Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs.

    Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs. by Satesh Ramdhani, Elisa Navarro, Evan Udine, Anastasia G Efthymiou, Brian M Schilder, Madison Parks, Alison Goate, Towfique Raj

    Published 2020-02-01
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  5. 5
    SORL1 variants and risk of late-onset Alzheimer’s disease

    SORL1 variants and risk of late-onset Alzheimer’s disease by Yonghong Li, Charles Rowland, Joseph Catanese, John Morris, Simon Lovestone, Michael C. O’Donovan, Alison Goate, Michael Owen, Julie Williams, Andrew Grupe

    Published 2008-02-01
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  6. 6
    Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

    Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG by Yan Zhou, Wanjiang Zhang, Rachael Easton, James W. Ray, Patricia Lampe, Zhihong Jiang, Anne L. Brunkan, Alison Goate, Eugene M. Johnson, Jane Y. Wu

    Published 2002-03-01
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  7. 7
    APOE3 AND APOE4 HIPSC-DERIVED ASTROCYTES DIFFERENTIALLY CONTRIBUTE TO ALZHEIMER’S PATHOLOGY IN CHIMERIC MICE

    APOE3 AND APOE4 HIPSC-DERIVED ASTROCYTES DIFFERENTIALLY CONTRIBUTE TO ALZHEIMER’S PATHOLOGY IN CHIMERIC MICE by Joan Cruz-Sesé, María Alfonso-Triguero, Jon Olano-Bringas, Leire Ruiz, Nuria Galbis, Pranav Preman, An Snellinx, Julia Tcw, Elena Alberdi, Alison Goate, Bart De Strooper, Amaia Mendiguren Arranz

    Published 2023-10-01
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  8. 8
    Dosage transmission disequilibrium test (dTDT) for linkage and association detection.

    Dosage transmission disequilibrium test (dTDT) for linkage and association detection. by Zhehao Zhang, Jen-Chyong Wang, William Howells, Peng Lin, Arpana Agrawal, Howard J Edenberg, Jay A Tischfield, Marc A Schuckit, Laura J Bierut, Alison Goate, John P Rice

    Published 2013-01-01
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  9. 9
    A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants

    A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants by Tim W. McInerney, Brian Fulton-Howard, Christopher Patterson, Devashi Paliwal, Lars S. Jermiin, Hardip R. Patel, Judy Pa, Russell H. Swerdlow, Alison Goate, Simon Easteal, Shea J. Andrews, for the Alzheimer’s Disease Neuroimaging Initiative

    Published 2021-09-01
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  10. 10
    P430: Application of ACMG/AMP variant classification guidelines to Alzheimer’s disease-associated genetic variation

    P430: Application of ACMG/AMP variant classification guidelines to Alzheimer’s disease-associated genetic variation by Alexa Dickson, Meagan Corliss, Jonathan Heusel, Ellen Ziegemeier, Jorge Llibre-Guerra, Alison Goate, Carlos Cruchaga, Alan Renton, Celeste Karch, Victoria Fernandez Hernandez, Gregory Day, Laura Courtney, Eric McDade, Randall Bateman, Kevin Bowling

    Published 2023-01-01
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  11. 11
    Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.

    Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. by Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graham

    Published 2018-11-01
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  12. 12
    Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models

    Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models by James A. Gregory, Emily Hoelzli, Rawan Abdelaal, Catherine Braine, Miguel Cuevas, Madeline Halpern, Natalie Barretto, Nadine Schrode, Güney Akbalik, Kristy Kang, Esther Cheng, Kathryn Bowles, Steven Lotz, Susan Goderie, Celeste M. Karch, Sally Temple, Alison Goate, Kristen J. Brennand, Hemali Phatnani

    Published 2020-06-01
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  13. 13
    Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

    Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease by Minghui Wang, Panos Roussos, Andrew McKenzie, Xianxiao Zhou, Yuji Kajiwara, Kristen J. Brennand, Gabriele C. De Luca, John F. Crary, Patrizia Casaccia, Joseph D. Buxbaum, Michelle Ehrlich, Sam Gandy, Alison Goate, Pavel Katsel, Eric Schadt, Vahram Haroutunian, Bin Zhang

    Published 2016-11-01
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  14. 14
    Sex specific molecular networks and key drivers of Alzheimer’s disease

    Sex specific molecular networks and key drivers of Alzheimer’s disease by Lei Guo, Jiqing Cao, Jianwei Hou, Yonghe Li, Min Huang, Li Zhu, Larry Zhang, Yeji Lee, Mariana Lemos Duarte, Xianxiao Zhou, Minghui Wang, Chia-Chen Liu, Yuka Martens, Michael Chao, Alison Goate, Guojun Bu, Vahram Haroutunian, Dongming Cai, Bin Zhang

    Published 2023-06-01
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  15. 15
    Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS.

    Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS. by Kristin R. Wildsmith, Jacob M. Basak, Bruce W. Patterson, Yuriy Pyatkivskyy, Jungsu Kim, Kevin E. Yarasheski, Jennifer X. Wang, Kwasi G. Mawuenyega, Hong Jiang, Maia Parsadanian, Hyejin Yoon, Tom Kasten, Wendy C. Sigurdson, Chengjie Xiong, Alison Goate, David M. Holtzman, Randall J. Bateman

    Published 2012-01-01
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  16. 16
    Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.

    Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease. by Maria Victoria Fernández, Jong Hun Kim, John P Budde, Kathleen Black, Alexandra Medvedeva, Ben Saef, Yuetiva Deming, Jorge Del-Aguila, Laura Ibañez, Umber Dube, Oscar Harari, Joanne Norton, Rachel Chasse, John C Morris, Alison Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga

    Published 2017-11-01
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  17. 17
    Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease

    Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease by Diane Xue, William S. Bush, Alan E. Renton, Edoardo A. Marcora, Joshua C. Bis, Brian W. Kunkle, The Alzheimer's Disease Sequencing Project, Eric Boerwinkle, Anita L. DeStefano, Lindsay Farrer, Alison Goate, Richard Mayeux, Margaret Pericak‐Vance, Gerard Schellenberg, Sudha Seshadri, Ellen Wijsman, Jonathan L. Haines, Elizabeth E. Blue

    Published 2021-01-01
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  18. 18
    Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

    Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease by Min Qiao, Annie J. Lee, Dolly Reyes‐Dumeyer, Giuseppe Tosto, Kelley Faber, Alison Goate, Alan Renton, Michael Chao, Brad Boeve, Carlos Cruchaga, Margaret Pericak‐Vance, Jonathan L. Haines, Roger Rosenberg, Debby Tsuang, Robert A. Sweet, David A. Bennett, Robert S. Wilson, Tatiana Foroud, Richard Mayeux, Badri N. Vardarajan

    Published 2023-05-01
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  19. 19
    Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.

    Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. by Nicholas J Izzo, Jinbin Xu, Chenbo Zeng, Molly J Kirk, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Gary Look, Gilbert Rishton, Hank Safferstein, Carlos Cruchaga, Alison Goate, Michael A Cahill, Ottavio Arancio, Robert H Mach, Rolf Craven, Elizabeth Head, Harry LeVine, Tara L Spires-Jones, Susan M Catalano

    Published 2014-01-01
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  20. 20
    Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood

    Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood by Jacquelyn L. Meyers, David B. Chorlian, Emma C. Johnson, Ashwini K. Pandey, Chella Kamarajan, Jessica E. Salvatore, Fazil Aliev, Stacey Subbie-Saenz de Viteri, Jian Zhang, Michael Chao, Manav Kapoor, Victor Hesselbrock, John Kramer, Samuel Kuperman, John Nurnberger, Jay Tischfield, Alison Goate, Tatiana Foroud, Danielle M. Dick, Howard J. Edenberg, Arpana Agrawal, Bernice Porjesz

    Published 2019-10-01
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