Review of Immunogenomics and the Role of Tumor Mutational Burden as a Biomarker for Immunotherapy Response by Javier Ros, Iosune Baraibar, Ana Vivancos, Jordi Rodon

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Use of ctDNA in early breast cancer: analytical validity and clinical potential by François Panet, Andri Papakonstantinou, Maria Borrell, Joan Vivancos, Ana Vivancos, Mafalda Oliveira

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Liquid Biopsy for Biomarker Testing in Non-Small Cell Lung Cancer: A European Perspective by Umberto Malapelle, Marcello Tiseo, Ana Vivancos, Joshua Kapp, M. Josè Serrano, Markus Tiemann

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Genomic heterogeneity and efficacy of PI3K pathway inhibitors in patients with gynaecological cancer by Victor Rodriguez-Freixinos, Fiorella Ruiz-Pace, Lorena Fariñas-Madrid, Ana Christina Garrido-Castro, Guillermo Villacampa, Paolo Nuciforo, Ana Vivancos, Rodrigo Dienstmann, Ana Oaknin

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High levels of chromosomal aberrations negatively associate with benefit to checkpoint inhibition in NSCLC by Enriqueta Felip, Ana Vivancos, Susana Cedres, Alex Martinez-Marti, Alejandro Navarro, Joan Frigola, Caterina Carbonell, Nuria Pardo, Ana Callejo, Mireia Soleda, Jose Jimenez, Javier Hernandez-Losa, Ramon Amat, Patricia Iranzo

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Dynamic changes in circulating tumor DNA assessed by shallow whole‐genome sequencing associate with clinical efficacy of checkpoint inhibitors in NSCLC by Caterina Carbonell, Joan Frigola, Nuria Pardo, Ana Callejo, Patricia Iranzo, Augusto Valdivia, Ilaria Priano, Susana Cedrés, Alex Martinez‐Marti, Alejandro Navarro, Laura Lenza, Mireia Soleda, Javier Gonzalo‐Ruiz, Ana Vivancos, Miriam Sansó, Enric Carcereny, Teresa Morán, Ramon Amat, Enriqueta Felip

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HER2DX genomic test in HER2-positive/hormone receptor-positive breast cancer treated with neoadjuvant trastuzumab and pertuzumab: A correlative analysis from the PerELISA trialRese... by Valentina Guarneri, Fara Bras..-Maristany, Maria Vittoria Dieci, Gaia Griguolo, Laia Par.., Mercedes Mar.ín-Aguilera, Federica Miglietta, Michele Bottosso, Carlo Alberto Giorgi, Paula Blasco, Oleguer Castillo, Patricia Galv..n, Ana Vivancos, Patricia Villagrasa, Joel S. Parker, Charles M. Perou, PierFranco Conte, Aleix Prat

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Molecular profiling of long‐term responders to immune checkpoint inhibitors in advanced non‐small cell lung cancer by Joan Frigola, Alejandro Navarro, Caterina Carbonell, Ana Callejo, Patricia Iranzo, Susana Cedrés, Alex Martinez‐Marti, Nuria Pardo, Nadia Saoudi‐Gonzalez, Debora Martinez, Jose Jimenez, Irene Sansano, Francesco M. Mancuso, Paolo Nuciforo, Luis M. Montuenga, Montse Sánchez‐Cespedes, Aleix Prat, Ana Vivancos, Enriqueta Felip, Ramon Amat

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Biomarkers of tumor-reactive CD4+ and CD8+ TILs associate with improved prognosis in endometrial cancer. by Xavier Matias-Guiu, Ana Vivancos, Jordi Ponce, Ignacio Melero, Alena Gros, Josep María Piulats, Carlos E De Andrea, Maria Lozano-Rabella, Jara Palomero, August Vidal, Carla Panisello, Ricky Tirtakasuma, Judit Díaz-Gómez, Daniela Grases, Helena Pasamar, Laura Arregui, Eduard Dorca Duch, Esther Guerra Fernández

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A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. by Rosaura Esteve-Puig, Rosa Gil, Elena González-Sánchez, Joan Josep Bech-Serra, Judit Grueso, Javier Hernández-Losa, Teresa Moliné, Francesc Canals, Berta Ferrer, Javier Cortés, Boris Bastian, Santiago Ramón Y Cajal, Juan Martín-Caballero, Juana Maria Flores, Ana Vivancos, Vicenç García-Patos, Juan Ángel Recio

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Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights by Rodrigo Dienstmann, Elena Elez, Guillem Argiles, Ignacio Matos, Enrique Sanz‐Garcia, Carolina Ortiz, Teresa Macarulla, Jaume Capdevila, Maria Alsina, Tamara Sauri, Helena Verdaguer, Marta Vilaro, Fiorella Ruiz‐Pace, Cristina Viaplana, Ariadna Garcia, Stefania Landolfi, Hector G. Palmer, Paolo Nuciforo, Jordi Rodon, Ana Vivancos, Josep Tabernero

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Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome‐reduced bacterium by Maria Lluch‐Senar, Javier Delgado, Wei‐Hua Chen, Verónica Lloréns‐Rico, Francis J O'Reilly, Judith AH Wodke, E Besray Unal, Eva Yus, Sira Martínez, Robert J Nichols, Tony Ferrar, Ana Vivancos, Arne Schmeisky, Jörg Stülke, Vera van Noort, Anne‐Claude Gavin, Peer Bork, Luis Serrano

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Impact of the COVID-19 pandemic in the early-onset colorectal cancer by Iosune Baraibar, Ariadna García, Francesc Salvà, Javier Ros, Nadia Saoudi, Raquel Comas, Gloria Castillo, Mireia Sanchis, Alejandro García-Álvarez, Jorge Hernando, Jaume Capdevila, Marta R Castells, Marc Martí, Stefania Landolfi, Eloy Espín, Begoña Navalpotro, Jorge Guevara, Cristina Dopazo, Paolo Nuciforo, Ana Vivancos, Josep Tabernero, Elena Élez

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Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis. by Franc Llorens, Katrin Thüne, Eulàlia Martí, Eirini Kanata, Dimitra Dafou, Daniela Díaz-Lucena, Ana Vivancos, Orr Shomroni, Saima Zafar, Matthias Schmitz, Uwe Michel, Natalia Fernández-Borges, Olivier Andréoletti, José Antonio Del Río, Juana Díez, Andre Fischer, Stefan Bonn, Theodoros Sklaviadis, Juan Maria Torres, Isidre Ferrer, Inga Zerr

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Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors by César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde, Jordi Rosell, Jonathan A. Fletcher, Suzanne George, Joan Carles, Joaquín Arribas

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Genomically matched therapy in refractory colorectal cancer according to ESMO Scale for Clinical Actionability of Molecular Targets: experience of a comprehensive cancer centre net... by Núria Mulet Margalef, Carmen Castillo, Miguel Mosteiro, Xavier Pérez, Susana Aguilar, Fiorella Ruíz‐Pace, Marta Gil, Carmen Cuadra, José Carlos Ruffinelli, Mercedes Martínez, Ferran Losa, Gema Soler, Àlex Teulé, Roser Castany, Rosa Gallego, Andrea Ruíz, Elena Garralda, Elena Élez, Ana Vivancos, Josep Tabernero, Ramon Salazar, Rodrigo Dienstmann, Cristina Santos Vivas

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Impact of circulating tumor DNA mutant allele fraction on prognosis in RAS‐mutant metastatic colorectal cancer by Elena Elez, Chiara Chianese, Enrique Sanz‐García, Erica Martinelli, Alba Noguerido, Francesco Mattia Mancuso, Ginevra Caratù, Judit Matito, Julieta Grasselli, Claudia Cardone, Riziero Esposito Abate, Giulia Martini, Cristina Santos, Teresa Macarulla, Guillem Argilés, Jaume Capdevila, Ariadna Garcia, Nuria Mulet, Evaristo Maiello, Nicola Normanno, Frederick Jones, Josep Tabernero, Fortunato Ciardello, Ramon Salazar, Ana Vivancos

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pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation by Olga Boix, Marion Martinez, Santiago Vidal, Marta Giménez-Alejandre, Lluís Palenzuela, Laura Lorenzo-Sanz, Laura Quevedo, Olivier Moscoso, Jorge Ruiz-Orera, Pilar Ximénez-Embún, Nikaoly Ciriaco, Paolo Nuciforo, Camille Stephan-Otto Attolini, M. Mar Albà, Javier Muñoz, Tian V. Tian, Ignacio Varela, Ana Vivancos, Santiago Ramón y Cajal, Purificación Muñoz, Carmen Rivas, María Abad

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Generation and Integrated Analysis of Advanced Patient‐Derived Orthoxenograft Models (PDOX) for the Rational Assessment of Targeted Therapies in Endometrial Cancer by Laura Devis‐Jauregui, August Vidal, Laura Plata‐Peña, Maria Santacana, Sandra García‐Mulero, Nuria Bonifaci, Eulàlia Noguera‐Delgado, Nuria Ruiz, Marta Gil, Eduard Dorca, Francisco J. Llobet, Laura Coll‐Iglesias, Katja Gassner, Maria Martinez‐Iniesta, Ruth Rodriguez‐Barrueco, Marc Barahona, Lola Marti, Francesc Viñals, Jordi Ponce, Rebeca Sanz‐Pamplona, Josep M. Piulats, Ana Vivancos, Xavier Matias‐Guiu, Alberto Villanueva, David Llobet‐Navas

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A 14-gene B-cell immune signature in early-stage triple-negative breast cancer (TNBC): a pooled analysis of seven studiesResearch in context by Benedetta Conte, Fara Brasó-Maristany, Adela Rodríguez Hernández, Tomás Pascual, Guillermo Villacampa, Francesco Schettini, Maria J. Vidal Losada, Elia Seguí, Laura Angelats, Isabel Garcia-Fructuoso, Raquel Gómez-Bravo, Natàlia Lorman-Carbó, Laia Paré, Mercedes Marín-Aguilera, Olga Martínez-Sáez, Barbara Adamo, Esther Sanfeliu, Beatrice Fratini, Claudette Falato, Núria Chic, Ana Vivancos, Patricia Villagrasa, Johan Staaf, Joel S. Parker, Charles M. Perou, Aleix Prat

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