Development and validation of risk prediction models for multiple cardiovascular diseases and Type 2 diabetes. by Mehrdad Rezaee, Igor Putrenko, Arsia Takeh, Andrea Ganna, Erik Ingelsson

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Quantifying the causal impact of biological risk factors on healthcare costs by Jiwoo Lee, Sakari Jukarainen, Antti Karvanen, Padraig Dixon, Neil M. Davies, George Davey Smith, Pradeep Natarajan, Andrea Ganna

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The lingering effects of Neanderthal introgression on human complex traits by Xinzhu Wei, Christopher R Robles, Ali Pazokitoroudi, Andrea Ganna, Alexander Gusev, Arun Durvasula, Steven Gazal, Po-Ru Loh, David Reich, Sriram Sankararaman

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Utilizing twins as controls for non-twin case-materials in genome wide association studies. by Andrea Ganna, Alfredo Ortega-Alonso, Aki Havulinna, Veikko Salomaa, Jaakko Kaprio, Nancy L Pedersen, Patrick F Sullivan, Erik Ingelsson, Christina M Hultman, Patrik K E Magnusson

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How do clinicians use post-COVID syndrome diagnosis? Analysis of clinical features in a Swedish COVID-19 cohort with 18 months’ follow-up: a national observational cohort and match... by Naja Hulvej Rod, Andrea Ganna, Lill Trogstad, Marie Eriksson, Osvaldo Fonseca-Rodríguez, Anne-Marie Fors Connolly, Per Minor Magnus, Hanna M Ollila, Ida Henriette Caspersen, Sebastian Kalucza, Johan Normark

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The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population by Markus Stenemo, Andrea Ganna, Samira Salihovic, Christoph Nowak, Johan Sundström, Vilmantas Giedraitis, Corey D. Broeckling, Jessica E. Prenni, Per Svensson, Patrik K.E. Magnusson, Lars Lind, Erik Ingelsson, Johan Ärnlöv, Tove Fall

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Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes by Mattia Cordioli, Andrea Corbetta, Hanna Maria Kariis, Sakari Jukarainen, Pekka Vartiainen, Tuomo Kiiskinen, Matteo Ferro, FinnGen, Estonian Biobank Research Team, Markus Perola, Mikko Niemi, Samuli Ripatti, Kelli Lehto, Lili Milani, Andrea Ganna

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Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies by Mashaal Sohail, Robert M Maier, Andrea Ganna, Alex Bloemendal, Alicia R Martin, Michael C Turchin, Charleston WK Chiang, Joel Hirschhorn, Mark J Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil R Sunyaev

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Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease. by Andrea Ganna, Samira Salihovic, Johan Sundström, Corey D Broeckling, Asa K Hedman, Patrik K E Magnusson, Nancy L Pedersen, Anders Larsson, Agneta Siegbahn, Mihkel Zilmer, Jessica Prenni, Johan Arnlöv, Lars Lind, Tove Fall, Erik Ingelsson

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Cystatin C is associated with adverse COVID-19 outcomes in diverse populations by Sam O. Kleeman, Mattia Cordioli, Paul R.H. J. Timmers, Atlas Khan, Pinkus Tober-Lau, Florian Kurth, Vadim Demichev, Hannah V. Meyer, James F. Wilson, Markus Ralser, Krzysztof Kiryluk, Andrea Ganna, Kenneth Baillie, Tobias Janowitz

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ADuLT: An efficient and robust time-to-event GWAS by Emil M. Pedersen, Esben Agerbo, Oleguer Plana-Ripoll, Jette Steinbach, Morten D. Krebs, David M. Hougaard, Thomas Werge, Merete Nordentoft, Anders D. Børglum, Katherine L. Musliner, Andrea Ganna, Andrew J. Schork, Preben B. Mortensen, John J. McGrath, Florian Privé, Bjarni J. Vilhjálmsson

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Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis by Pavel Loginovic, Feiyi Wang, Jiang Li, Lauric Ferrat, Uyenlinh L. Mirshahi, H. Shanker Rao, Axel Petzold, Jessica Tyrrell, Harry D. Green, Michael N. Weedon, Andrea Ganna, Tiinamaija Tuomi, David J. Carey, UKBB Eye & Vision Consortium, FinnGen, Geisinger-Regeneron DiscovEHR Collaboration, Richard A. Oram, Tasanee Braithwaite

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Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study. by Christoph Nowak, Samira Salihovic, Andrea Ganna, Stefan Brandmaier, Taru Tukiainen, Corey D Broeckling, Patrik K Magnusson, Jessica E Prenni, Rui Wang-Sattler, Annette Peters, Konstantin Strauch, Thomas Meitinger, Vilmantas Giedraitis, Johan Ärnlöv, Christian Berne, Christian Gieger, Samuli Ripatti, Lars Lind, Nancy L Pedersen, Johan Sundström, Erik Ingelsson, Tove Fall

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Correction: Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study. by Christoph Nowak, Samira Salihovic, Andrea Ganna, Stefan Brandmaier, Taru Tukiainen, Corey D Broeckling, Patrik K Magnusson, Jessica E Prenni, Rui Wang-Sattler, Annette Peters, Konstantin Strauch, Thomas Meitinger, Vilmantas Giedraitis, Johan Ärnlöv, Christian Berne, Christian Gieger, Samuli Ripatti, Lars Lind, Nancy L Pedersen, Johan Sundström, Erik Ingelsson, Tove Fall

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Genome-wide risk prediction of common diseases across ancestries in one million people by Nina Mars, Sini Kerminen, Yen-Chen A. Feng, Masahiro Kanai, Kristi Läll, Laurent F. Thomas, Anne Heidi Skogholt, Pietro della Briotta Parolo, Benjamin M. Neale, Jordan W. Smoller, Maiken E. Gabrielsen, Kristian Hveem, Reedik Mägi, Koichi Matsuda, Yukinori Okada, Matti Pirinen, Aarno Palotie, Andrea Ganna, Alicia R. Martin, Samuli Ripatti

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Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity by Veera M. Rajagopal, Andrea Ganna, Jonathan R. I. Coleman, Andrea Allegrini, Georgios Voloudakis, Jakob Grove, Thomas D. Als, Henriette T. Horsdal, Liselotte Petersen, Vivek Appadurai, Andrew Schork, Alfonso Buil, Cynthia M. Bulik, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, David M. Hougaard, Ole Mors, Merete Nordentoft, Thomas Werge, iPSYCH-Broad Consortium, Preben Bo Mortensen, Gerome Breen, Panos Roussos, Robert Plomin, Esben Agerbo, Anders D. Børglum, Ditte Demontis

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High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene by Fedik Rahimov, Pekka Nieminen, Priyanka Kumari, Emma Juuri, Tiit Nikopensius, Kitt Paraiso, Jakob German, Antti Karvanen, Mart Kals, Abdelrahman G. Elnahas, Juha Karjalainen, Mitja Kurki, Aarno Palotie, FinnGen, Estonian Biobank Research Team, Arja Heliövaara, Tõnu Esko, Sakari Jukarainen, Priit Palta, Andrea Ganna, Anjali P. Patni, Daniel Mar, Karol Bomsztyk, Julie Mathieu, Hannele Ruohola-Baker, Axel Visel, Walid D. Fakhouri, Brian C. Schutte, Robert A. Cornell, David P. Rice

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A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk by Bradley Jermy, Kristi Läll, Brooke N. Wolford, Ying Wang, Kristina Zguro, Yipeng Cheng, Masahiro Kanai, Stavroula Kanoni, Zhiyu Yang, Tuomo Hartonen, Remo Monti, Julian Wanner, Omar Youssef, Estonian Biobank research team, FinnGen, Christoph Lippert, David van Heel, Yukinori Okada, Daniel L. McCartney, Caroline Hayward, Riccardo E. Marioni, Simone Furini, Alessandra Renieri, Alicia R. Martin, Benjamin M. Neale, Kristian Hveem, Reedik Mägi, Aarno Palotie, Henrike Heyne, Nina Mars, Andrea Ganna, Samuli Ripatti

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Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility by Irene V. van Blokland, Pauline Lanting, Anil P. S. Ori, Judith M. Vonk, Robert C. A. Warmerdam, Johanna C. Herkert, Floranne Boulogne, Annique Claringbould, Esteban A. Lopera-Maya, Meike Bartels, Jouke-Jan Hottenga, Andrea Ganna, Juha Karjalainen, Lifelines COVID-19 cohort study, The COVID-19 Host Genetics Initiative, Caroline Hayward, Chloe Fawns-Ritchie, Archie Campbell, David Porteous, Elizabeth T. Cirulli, Kelly M. Schiabor Barrett, Stephen Riffle, Alexandre Bolze, Simon White, Francisco Tanudjaja, Xueqing Wang, Jimmy M. Ramirez, Yan Wei Lim, James T. Lu, Nicole L. Washington, Eco J. C. de Geus, Patrick Deelen, H. Marike Boezen, Lude H. Franke

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Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries by Seyedeh M. Zekavat, Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan Bloom, Timothy Poterba, Cotton Seed, Jason Ernst, Mark Chaffin, Jesse Engreitz, Gina M. Peloso, Ani Manichaikul, Chaojie Yang, Kathleen A. Ryan, Mao Fu, W. Craig Johnson, Michael Tsai, Matthew Budoff, Ramachandran S. Vasan, L. Adrienne Cupples, Jerome I. Rotter, Stephen S. Rich, Wendy Post, Braxton D. Mitchell, Adolfo Correa, Andres Metspalu, James G. Wilson, Veikko Salomaa, Manolis Kellis, Mark J. Daly, Benjamin M. Neale, Steven McCarroll, Ida Surakka, Tonu Esko, Andrea Ganna, Samuli Ripatti, Sekar Kathiresan, Pradeep Natarajan, NHLBI TOPMed Lipids Working Group

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