Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases by Theo Battista, Gianni Colotti, Andrea Ilari, Annarita Fiorillo

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The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway. by Annarita Fiorillo, Gianni Colotti, Alberto Boffi, Paola Baiocco, Andrea Ilari

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Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells by Gianni Colotti, Elena Poser, Annarita Fiorillo, Ilaria Genovese, Valerio Chiarini, Andrea Ilari

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Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis. by Vasiliki S Lalioti, Andrea Ilari, David J O'Connell, Elena Poser, Ignacio V Sandoval, Gianni Colotti

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The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme. by Annarita Fiorillo, Maria Petrosino, Andrea Ilari, Alessandra Pasquo, Alessandra Cipollone, Maristella Maggi, Roberta Chiaraluce, Valerio Consalvi

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The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference. by Annarita Fiorillo, Daniele di Marino, Lucia Bertuccini, Allegra Via, Edoardo Pozio, Serena Camerini, Andrea Ilari, Marco Lalle

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Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design by Annarita Fiorillo, Annarita Fiorillo, Gianni Colotti, Gianni Colotti, Cécile Exertier, Anastasia Liuzzi, Francesca Seghetti, Alessandra Salerno, Jessica Caciolla, Andrea Ilari

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Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme. by Lorenzo Turcano, Theo Battista, Esther Torrente De Haro, Antonino Missineo, Cristina Alli, Giacomo Paonessa, Gianni Colotti, Steven Harper, Annarita Fiorillo, Andrea Ilari, Alberto Bresciani

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Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening. by Lorenzo Turcano, Esther Torrente, Antonino Missineo, Matteo Andreini, Marina Gramiccia, Trentina Di Muccio, Ilaria Genovese, Annarita Fiorillo, Steven Harper, Alberto Bresciani, Gianni Colotti, Andrea Ilari

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Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage by Eris Bidollari, Giovannina Rotundo, Daniela Ferrari, Ornella Candido, Laura Bernardini, Federica Consoli, Alessandro De Luca, Iolanda Santimone, Giuseppe Lamorte, Andrea Ilari, Ferdinando Squitieri, Angelo Luigi Vescovi, Jessica Rosati

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Inhibition of <i>Leishmania infantum</i> Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site by Valentina Noemi Madia, Davide Ialongo, Elisa Patacchini, Cécile Exertier, Lorenzo Antonelli, Gianni Colotti, Antonella Messore, Valeria Tudino, Francesco Saccoliti, Luigi Scipione, Andrea Ilari, Roberta Costi, Roberto Di Santo

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Engineered ferritin for lanthanide binding. by Lorenzo Calisti, Matilde Cardoso Trabuco, Alberto Boffi, Claudia Testi, Linda Celeste Montemiglio, Amédée des Georges, Irene Benni, Andrea Ilari, Bartłomiej Taciak, Maciej Białasek, Tomasz Rygiel, Magdalena Król, Paola Baiocco, Alessandra Bonamore

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Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives by Francesco Saccoliti, Gabriella Angiulli, Giovanni Pupo, Luca Pescatori, Valentina Noemi Madia, Antonella Messore, Gianni Colotti, Annarita Fiorillo, Luigi Scipione, Marina Gramiccia, Trentina Di Muccio, Roberto Di Santo, Roberta Costi, Andrea Ilari

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