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1381 Discovery of ALG-093989, a highly potent and orally bioavailable small molecule PD-L1 inhibitor for the treatment of cancers by Cheng Liu, Sarah Stevens, Heleen Roose, Kha Le, Kristina Rekstyte-Matiene, Kusum Gupta, Sandra Chang, Vladimir Serebryany, Lillian Adame, Antitsa Stoycheva, Lawrence M Blatt, Leonid Beigelman, Sushmita Chanda, David B Smith, Julian A Symons, Andreas Jekle, Tongfei Wu
Published 2023-11-01Article -
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1382 Discovery of ALG-094103, a liver-targeted and orally bioavailable small molecule PD-L1 inhibitor for the treatment of liver cancer by Cheng Liu, Sarah Stevens, Heleen Roose, Kha Le, Kristina Rekstyte-Matiene, Kusum Gupta, Sandra Chang, Vladimir Serebryany, Lillian Adame, Antitsa Stoycheva, Lawrence M Blatt, Leonid Beigelman, Sushmita Chanda, David B Smith, Julian A Symons, Andreas Jekle, Tongfei Wu
Published 2023-11-01Article -
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The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir by Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K. Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas Jekle, Lawrence M. Blatt, Leonid Beigelman, Julian A. Symons, Pierre Raboisson, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Jerome Deval, Koen Vandyck
Published 2023-02-01
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