An Interview with Cesare Montecucco by Mandë Holford, Andreas Rummel

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Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN) by Hans Bigalke, Andreas Rummel

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Preface Biological Toxins—Ancient Molecules Posing a Current Threat by Brigitte G. Dorner, Andreas Rummel

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The 25 kDa H_CN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity by Julian Deppe, Jasmin Weisemann, Stefan Mahrhold, Andreas Rummel

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Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin by Jasmin Weisemann, Daniel Stern, Stefan Mahrhold, Brigitte G. Dorner, Andreas Rummel

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Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H by Guorui Yao, Kwok-ho Lam, Kay Perry, Jasmin Weisemann, Andreas Rummel, Rongsheng Jin

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Qualitative and Quantitative Detection of Botulinum Neurotoxins from Complex Matrices: Results of the First International Proficiency Test by Sylvia Worbs, Uwe Fiebig, Reinhard Zeleny, Heinz Schimmel, Andreas Rummel, Werner Luginbühl, Brigitte G. Dorner

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Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments by Laura von Berg, Daniel Stern, Jasmin Weisemann, Andreas Rummel, Martin Bernhard Dorner, Brigitte Gertrud Dorner

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Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1 by Maren Schenke, Hélène-Christine Prause, Wiebke Bergforth, Adina Przykopanski, Andreas Rummel, Frank Klawonn, Bettina Seeger

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A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1 by Kwok-ho Lam, Zhuojun Guo, Nadja Krez, Tsutomu Matsui, Kay Perry, Jasmin Weisemann, Andreas Rummel, Mark E. Bowen, Rongsheng Jin

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Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission. by Giulia Zanetti, Stefan Sikorra, Andreas Rummel, Nadja Krez, Elisa Duregotti, Samuele Negro, Tina Henke, Ornella Rossetto, Thomas Binz, Marco Pirazzini

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A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding by Guorui Yao, Kwok-ho Lam, Jasmin Weisemann, Lisheng Peng, Nadja Krez, Kay Perry, Charles B. Shoemaker, Min Dong, Andreas Rummel, Rongsheng Jin

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Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities by Stefan Sikorra, Martin Skiba, Martin B. Dorner, Jasmin Weisemann, Mirjam Weil, Sylvia Valdezate, Bazbek Davletov, Andreas Rummel, Brigitte G. Dorner, Thomas Binz

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Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity. by Kwangkook Lee, Shenyan Gu, Lei Jin, Thi Tuc Nghi Le, Luisa W Cheng, Jasmin Strotmeier, Anna Magdalena Kruel, Guorui Yao, Kay Perry, Andreas Rummel, Rongsheng Jin

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Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid by Maria B. Nowakowska, Katja Selby, Adina Przykopanski, Maren Krüger, Nadja Krez, Brigitte G. Dorner, Martin B. Dorner, Rongsheng Jin, Nigel P. Minton, Andreas Rummel, Miia Lindström

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A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency. by Daniel Stern, Jasmin Weisemann, Alexander Le Blanc, Laura von Berg, Stefan Mahrhold, Janett Piesker, Michael Laue, Peter B Luppa, Martin Bernhard Dorner, Brigitte Gertrud Dorner, Andreas Rummel

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Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype. by Skadi Kull, K Melanie Schulz, Jasmin Weisemann, Sebastian Kirchner, Tanja Schreiber, Alexander Bollenbach, P Wojtek Dabrowski, Andreas Nitsche, Suzanne R Kalb, Martin B Dorner, John R Barr, Andreas Rummel, Brigitte G Dorner

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Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2 by Zheng Liu, Pyung-Gang Lee, Nadja Krez, Kwok-ho Lam, Hao Liu, Adina Przykopanski, Peng Chen, Guorui Yao, Sicai Zhang, Jacqueline M. Tremblay, Kay Perry, Charles B. Shoemaker, Andreas Rummel, Min Dong, Rongsheng Jin

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Innovative and Highly Sensitive Detection of <i>Clostridium perfringens</i> Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies by Thea Neumann, Maren Krüger, Jasmin Weisemann, Stefan Mahrhold, Daniel Stern, Martin B. Dorner, Cécile Feraudet-Tarisse, Christopher Pöhlmann, Katharina Schulz, Ute Messelhäußer, Dagmar Rimek, Frank Gessler, Thomas Elßner, Stéphanie Simon, Andreas Rummel, Brigitte G. Dorner

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Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test by Jasmin Weisemann, Nadja Krez, Uwe Fiebig, Sylvia Worbs, Martin Skiba, Tanja Endermann, Martin B. Dorner, Tomas Bergström, Amalia Muñoz, Ingrid Zegers, Christian Müller, Stephen P. Jenkinson, Marc-Andre Avondet, Laurence Delbrassinne, Sarah Denayer, Reinhard Zeleny, Heinz Schimmel, Crister Åstot, Brigitte G. Dorner, Andreas Rummel

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