TP53 Mutations and Clinical Outcome in Chronic Lymphocytic Leukemia: Is a Threshold Still Needed? by Riccardo Bomben, Antonella Zucchetto, Federico Pozzo, Erika Tissino, Tamara Bittolo, Jacopo Olivieri, Annalisa Chiarenza, Francesco Zaja, Maria Ilaria Del Principe, Davide Rossi, Valter Gattei

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P030: Baseline IgM amount can identify patients with adverse outcome despite a PET-2 adapted treatment in classical Hodgkin Lymphoma: results from a real-life single-center study i by Alessandra Romano, Claudio Cerchione, Gabriella Santuccio, Marialudovica Le Moli, Annalisa Chiarenza, Amalia Figuera, Giovanna Motta, L. Caruso, Sofia Lanza, A. Petronaci, S. Poidomani, Massimo Ippolito, Francesco Di Raimondo

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Mesenchymal Stem Cells (MSC) Regulate Activation of Granulocyte-Like Myeloid Derived Suppressor Cells (G-MDSC) in Chronic Myeloid Leukemia Patients. by Cesarina Giallongo, Alessandra Romano, Nunziatina Laura Parrinello, Piera La Cava, Maria Violetta Brundo, Vincenzo Bramanti, Fabio Stagno, Paolo Vigneri, Annalisa Chiarenza, Giuseppe Alberto Palumbo, Daniele Tibullo, Francesco Di Raimondo

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BNT162b2 mRNA vaccination affects the gut microbiome composition of patients with follicular lymphoma and chronic lymphocytic leukemia by Annalisa Chiarenza, Gaia Vertillo Aluisio, Nunziatina Laura Parrinello, Sara Marino, Anna Maria Corsale, Grete Francesca Privitera, MojtabaShekarkar Azgomi, Enrico La Spina, Daniela Cambria, Angelo Curtopelle, Gaetano Isola, Cirino Botta, Francesco Di Raimondo, Alessandra Romano, Maria Santagati

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Impaired nodal shrinkage and apoptosis define the independent adverse outcome of NOTCH1 mutated patients under ibrutinib therapy in chronic lymphocytic leukaemia by Giovanni Del Poeta, Annalisa Biagi, Luca Laurenti, Annalisa Chiarenza, Federico Pozzo, Idanna Innocenti, Massimiliano Postorino, Francesca Maria Rossi, Maria Ilaria Del Principe, Riccardo Bomben, Paolo de Fabritiis, Antonio Bruno, Maria Cantonetti, Francesco Di Raimondo, Antonella Zucchetto, Valter Gattei

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<i>SF3B1</i>-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation by Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei

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P1558: PROPHYLAXIS WITH TIXAGEVIMAB-CILGAVIMAB IN SINGLE-CENTER EXPERIENCE CAN REDUCE SEVERE COMPLICATIONS RELATED TO SARS-COV-2 INFECTION IN HEMATOLOGICAL PATIENTS by Andrea Duminuco, Antonella Nardo, Alessandra Orofino, Alessandra Romano, Amalia Stefania Figuera, Annalisa Chiarenza, Uros Markovic, Laura Caruso, Giuliana Giunta, Salvatore Leotta, Giuseppe Milone, Alessandra Cupri, Concetta Conticello, Vittorio Del Fabro, Elisa Mauro, Cinzia Maugeri, Calogero Vetro, Marina Parisi, Francesco DI Raimondo, Giuseppe Palumbo

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Mutations in the 3′ untranslated region of NOTCH1 are associated with low CD20 expression levels chronic lymphocytic leukemia by Tamara Bittolo, Federico Pozzo, Riccardo Bomben, Tiziana D’Agaro, Vanessa Bravin, Pietro Bulian, Francesca Maria Rossi, Antonella Zucchetto, Massimo Degan, Paolo Macor, Giovanni D’Arena, Annalisa Chiarenza, Francesco Zaja, Gabriele Pozzato, Francesco Di Raimondo, Davide Rossi, Gianluca Gaidano, Giovanni Del Poeta, Valter Gattei, Michele Dal Bo

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P594: THE CXCR4-LOW/CD5-HIGH PROLIFERATIVE FRACTION IS ENRICHED IN BTK MUTATIONS AND ANTICIPATES RELAPSE IN IBRUTINIB-TREATED CLL by Federico Pozzo, Gabriela Forestieri, Giulia Ianna, Filippo Vit, Erika Tissino, Tamara Bittolo, Robel Papotti, Lodovico Terzi DI Bergamo, Agostino Steffan, Roberta Laureana, Agostino Tafuri, Annalisa Chiarenza, Francesco DI Raimondo, Jacopo Olivieri, Francesco Zaja, Luca Laurenti, Maria Ilaria DEL Principe, Riccardo Bomben, Antonella Zucchetto, Davide Rossi, Valter Gattei

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P606: MEASUREMENT OF INTRACLONAL DIVERSIFICATION REFINES THE PROGNOSTIC IMPACT OF IGHV MUTATIONS IN CLL by Filippo Vit, Tamara Bittolo, Robel Papotti, Federico Pozzo, Antonella Zucchetto, Erika Tissino, Eva Zaina, Ilaria Catarossi, Roberta Laureana, Jacopo Olivieri, Pietro Bulian, Luciano Levato, Giovanni D’arena, Daniele Armiento, Alberto Zamò, Ellen Leich, Andreas Rosenwald, Evgeny Arons, Robert J. Kreitman, Massimo Gentile, Luca Laurenti, Francesco Zaja, Agostino Tafuri, Annalisa Chiarenza, Maria Ilaria DEL Principe, Valter Gattei, Riccardo Bomben

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Mutational status of IGHV is the most reliable prognostic marker in trisomy 12 chronic lymphocytic leukemia by Pietro Bulian, Riccardo Bomben, Michele Dal Bo, Antonella Zucchetto, Francesca Maria Rossi, Massimo Degan, Federico Pozzo, Tamara Bittolo, Vanessa Bravin, Tiziana D’Agaro, Michaela Cerri, Annalisa Chiarenza, Kari G. Chaffee, Adalgisa Condoluci, Giovanni D’Arena, Michele Spina, Francesco Zaja, Gabriele Pozzato, Francesco Di Raimondo, Davide Rossi, Giovanni Del Poeta, Gianluca Gaidano, Tait D. Shanafelt, Valter Gattei

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S143: NATURAL CLONAL EVOLUTION OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH BIMODAL CD49D EXPRESSION REVEALS CD49D PLASTICITY by Erika Tissino, Nicola Calonaci, Federico Pozzo, Filippo Vit, Annalisa Gaglio, Lodovico Terzi DI Bergamo, Tamara Bittolo, Francesca Maria Rossi, Robel Papotti, Ilaria Catarossi, Eva Zaina, Paola Nanni, Riccardo Bergamin, Leonardo Egidi, Giovanni Santacatterina, Salvatore Milite, Maria Ilaria Del Principe, Roberta Laureana, Jacopo Olivieri, Francesco Zaja, Annalisa Chiarenza, Davide Rossi, Riccardo Bomben, Valter Gattei, Antonella Zucchetto, Giulio Caravagna

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Coexisting conditions and concomitant medications do not affect venetoclax management and survival in chronic lymphocytic leukemia by Anna Maria Frustaci, Giovanni Del Poeta, Andrea Visentin, Paolo Sportoletti, Alberto Fresa, Candida Vitale, Roberta Murru, Annalisa Chiarenza, Alessandro Sanna, Francesca Romana Mauro, Gianluigi Reda, Massimo Gentile, Marzia Varettoni, Claudia Baratè, Chiara Borella, Antonino Greco, Marina Deodato, Giulia Zamprogna, Roberta Laureana, Alessandra Cipiciani, Andrea Galitzia, Angelo Curto Pelle, Francesca Morelli, Lucio Malvisi, Marta Coscia, Luca Laurenti, Livio Trentin, Marco Montillo, Roberto Cairoli, Alessandra Tedeschi

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A laboratory-based scoring system predicts early treatment in Rai 0 chronic lymphocytic leukemia by Jared A. Cohen, Francesca Maria Rossi, Antonella Zucchetto, Riccardo Bomben, Lodovico Terzi-di-Bergamo, Kari G. Rabe, Massimo Degan, Agostino Steffan, Jerry Polesel, Enrico Santinelli, Idanna Innocenti, Giovanna Cutrona, Giovanni D’Arena, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Davide Rossi, Francesco Di Raimondo, Luca Laurenti, Massimo Gentile, Fortunato Morabito, Antonino Neri, Manlio Ferrarini, Christopher D. Fegan, Christopher J. Pepper, Giovanni Del Poeta, Sameer A. Parikh, Neil E. Kay, Valter Gattei

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CD49d expression is included in a revised 4‐factor model predicting outcome in patients with chronic lymphocytic leukemia treated with ibrutinib: A multicenter real‐world experienc... by Riccardo Bomben, Antonella Zucchetto, Roberta Laureana, Annalisa Chiarenza, Jacopo Olivieri, Erika Tissino, Francesca M. Rossi, Filippo Vit, Tamara Bittolo, Robel Papotti, Federico Pozzo, Annalisa Gaglio, Massimo Degan, Jerry Polesel, Roberto Marasca, Andrea Visentin, Riccardo Moia, Idanna Innocenti, Candida Vitale, Roberta Murru, Marzia Varettoni, Agostino Tafuri, Francesco Zaja, Massimiliano Postorino, Enrica A. Martino, Adalgisa Condoluci, Davide Rossi, Antonio Cuneo, Francesco Di Raimondo, Paolo Sportoletti, Ilaria Del Giudice, Robin Foà, Francesca R. Mauro, Marta Coscia, Luca Laurenti, Gianluca Gaidano, Livio Trentin, Maria I. Del Principe, Massimo Gentile, Valter Gattei

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P597: XPO1 MUTATIONS IDENTIFY EARLY STAGE CLL CHARACTERIZED BY SHORTER TIME TO FIRST TREATMENT AND ENHANCED BCR SIGNALING by Donatella Talotta, Riccardo Moia, Lodovico Terzi DI Bergamo, Riccardo Bomben, Gabriela Forestieri, Valeria Spina, Alessio Bruscaggin, Chiara Cosentino, Mohammad Almasri, Riccardo Dondolin, Tamara Bittolo, Antonella Zucchetto, Stefano Baldoni, Ilaria Del Giudice, Francesca Romana Mauro, Rossana Maffei, Annalisa Chiarenza, Agostino Tafuri, Roberta Laureana, Maria Ilaria Del Principe, Francesco Zaja, Giovanni D’arena, Jacopo Olivieri, Silvia Rasi, Abdurraouf Mahmoud, Wael Al Essa, Bassel Awikeh, Sreekar Kogila, Matteo Bellia, Samir Mouhssine, Paolo Sportoletti, Roberto Marasca, Lydia Scarfò, Paolo Ghia, Valter Gattei, Robin Foà, Davide Rossi, Gianluca Gaidano

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Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib: a GIMEMA, ERIC and UK CLL FORUM study by Antonio Cuneo, George Follows, Gian Matteo Rigolin, Alfonso Piciocchi, Alessandra Tedeschi, Livio Trentin, Angeles Medina Perez, Marta Coscia, Luca Laurenti, Gerardo Musuraca, Lucia Farina, Alfredo Rivas Delgado, Ester Maria Orlandi, Piero Galieni, Francesca Romana Mauro, Carlo Visco, Angela Amendola, Atto Billio, Roberto Marasca, Annalisa Chiarenza, Vittorio Meneghini, Fiorella Ilariucci, Monia Marchetti, Stefano Molica, Francesca Re, Gianluca Gaidano, Marcos Gonzalez, Francesco Forconi, Stefania Ciolli, Agostino Cortelezzi, Marco Montillo, Lukas Smolej, Anna Schuh, Toby A. Eyre, Ben Kennedy, Kris M. Bowles, Marco Vignetti, Javier de la Serna, Carol Moreno, Robin Foà, Paolo Ghia

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Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia by Fary Diop, Riccardo Moia, Chiara Favini, Elisa Spaccarotella, Lorenzo De Paoli, Alessio Bruscaggin, Valeria Spina, Lodovico Terzi-di-Bergamo, Francesca Arruga, Chiara Tarantelli, Clara Deambrogi, Silvia Rasi, Ramesh Adhinaveni, Andrea Patriarca, Simone Favini, Sruthi Sagiraju, Clive Jabangwe, Ahad A. Kodipad, Denise Peroni, Francesca R. Mauro, Ilaria Del Giudice, Francesco Forconi, Agostino Cortelezzi, Francesco Zaja, Riccardo Bomben, Francesca Maria Rossi, Carlo Visco, Annalisa Chiarenza, Gian Matteo Rigolin, Roberto Marasca, Marta Coscia, Omar Perbellini, Alessandra Tedeschi, Luca Laurenti, Marina Motta, David Donaldson, Phil Weir, Ken Mills, Patrick Thornton, Sarah Lawless, Francesco Bertoni, Giovanni Del Poeta, Antonio Cuneo, Antonia Follenzi, Valter Gattei, Renzo Luciano Boldorini, Mark Catherwood, Silvia Deaglio, Robin Foà, Gianluca Gaidano°, Davide Rossi°

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