Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis. by Noelle M Nieskens, Yukiko Miyamoto, Brianna M Hurysz, Anthony J O'Donoghue, Lars Eckmann

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Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z‑Arg-Lys-AOMK by Jehad Almaliti, Momen Alhindy, Michael C. Yoon, Vivian Hook, Tadeusz F. Molinski, Anthony J. O’Donoghue, William H. Gerwick

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A GMR enzymatic assay for quantifying nuclease and peptidase activity by Michael Sveiven, Ana K. Serrano, Joshua Rosenberg, Douglas J. Conrad, Drew A. Hall, Drew A. Hall, Anthony J. O’Donoghue

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Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystati... by Hana Dvořáková, Roman Leontovyč, Tomáš Macháček, Anthony J. O'Donoghue, Ondřej Šedo, Zbyněk Zdráhal, Charles S. Craik, Conor R. Caffrey, Petr Horák, Libor Mikeš

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A dual-binding magnetic immunoassay to predict spontaneous preterm birth by Michael Sveiven, Andrew Gassman, Joshua Rosenberg, Matthew Chan, Jay Boniface, Anthony J. O’Donoghue, Louise C. Laurent, Drew A. Hall, Drew A. Hall

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Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors by Jan Silhan, Pavla Fajtova, Jitka Bartosova, Brianna M. Hurysz, Jehad Almaliti, Yukiko Miyamoto, Lars Eckmann, William H. Gerwick, Anthony J. O’Donoghue, Evzen Boura

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Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. by Starlynn C Clarke, Phillip A Dumesic, Christina M Homer, Anthony J O'Donoghue, Florencia La Greca, Lenka Pallova, Pavel Majer, Hiten D Madhani, Charles S Craik

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Characterization of glutamate carboxypeptidase 2 orthologs in trematodes by Lucie Jedlickova, Kristyna Peterkova, Enoch Mensah Boateng, Lenka Ulrychova, Vojtech Vacek, Zsofia Kutil, Zhenze Jiang, Zora Novakova, Ivan Snajdr, Juan Kim, Anthony J. O’Donoghue, Cyril Barinka, Jan Dvorak

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Clickable Probes for Pathogen Proteasomes: Synthesis and Applications by Lawrence J. Liu, Bobby Lucero, Cindy Manriquez-Rodriguez, Karol R. Francisco, Thaiz R. Teixeira, Darius J. Yohannan, Carlo Ballatore, Samuel A. Myers, Anthony J. O’Donoghue, Conor R. Caffrey

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High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma by Elisa Maffioli, Zhenze Jiang, Simona Nonnis, Armando Negri, Valentina Romeo, Christopher B. Lietz, Vivian Hook, Giuseppe Ristagno, Giuseppe Baselli, Erik B. Kistler, Federico Aletti, Anthony J. O’Donoghue, Gabriella Tedeschi

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Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L by Ittipat Meewan, Jacob Kattoula, Julius Y. Kattoula, Danielle Skinner, Pavla Fajtová, Miriam A. Giardini, Brendon Woodworth, James H. McKerrow, Jair Lage de Siqueira-Neto, Anthony J. O’Donoghue, Ruben Abagyan

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SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. by Adrian Leontovyč, Lenka Ulrychová, Anthony J O'Donoghue, Jiří Vondrášek, Lucie Marešová, Martin Hubálek, Pavla Fajtová, Marta Chanová, Zhenze Jiang, Charles S Craik, Conor R Caffrey, Michael Mareš, Jan Dvořák, Martin Horn

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Immunoproteasome functions explained by divergence in cleavage specificity and regulation by Michael B Winter, Florencia La Greca, Shirin Arastu-Kapur, Francesco Caiazza, Peter Cimermancic, Tonia J Buchholz, Janet L Anderl, Matthew Ravalin, Markus F Bohn, Andrej Sali, Anthony J O'Donoghue, Charles S Craik

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Evaluating Antimalarial Proteasome Inhibitors for Efficacy in Babesia Blood Stage Cultures by Luïse Robbertse, Pavla Fajtová, Pavla Šnebergerová, Marie Jalovecká, Viktoriya Levytska, Elany Barbosa da Silva, Vandna Sharma, Petr Pachl, Jehad Almaliti, Momen Al-Hindy, William H. Gerwick, Evžen Bouřa, Anthony J. O’Donoghue, Daniel Sojka

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Small molecule in situ resin capture provides a compound first approach to natural product discovery by Alexander Bogdanov, Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke, Elany Barbosa da Silva, Anthony J. O’Donoghue, Lani F. Wu, Steven J. Altschuler, Tadeusz F. Molinski, Paul R. Jensen

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The importance of good practices and false hits for QSAR-driven virtual screening real application: a SARS-CoV-2 main protease (Mpro) case study by Mateus Sá Magalhães Serafim, Mateus Sá Magalhães Serafim, Simone Queiroz Pantaleão, Elany Barbosa da Silva, James H. McKerrow, Anthony J. O’Donoghue, Bruno Eduardo Fernandes Mota, Kathia Maria Honorio, Kathia Maria Honorio, Vinícius Gonçalves Maltarollo

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Plasma enzymatic activity, proteomics and peptidomics in COVID-19-induced sepsis: A novel approach for the analysis of hemostasis by Fernando Dos Santos, Joyce B. Li, Nathalia Juocys, Nathalia Juocys, Rafi Mazor, Laura Beretta, Nicole G. Coufal, Michael T. Y. Lam, Mazen F. Odish, Maria Claudia Irigoyen, Anthony J. O’Donoghue, Federico Aletti, Erik B. Kistler, Erik B. Kistler

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Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system by Victoria Røyseth, Brianna M. Hurysz, Anna-Karina Kaczorowska, Sebastian Dorawa, Anita-Elin Fedøy, Hasan Arsın, Mateus Sá M. Serafim, Mateus Sá M. Serafim, Samuel A. Myers, Olesia Werbowy, Tadeusz Kaczorowski, Runar Stokke, Anthony J. O’Donoghue, Ida Helene Steen

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Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome by Robert A. Quinn, Sandeep Adem, Robert H. Mills, William Comstock, Lindsay DeRight Goldasich, Gregory Humphrey, Alexander A. Aksenov, Alexei V. Melnik, Ricardo da Silva, Gail Ackermann, Nuno Bandeira, David J. Gonzalez, Doug Conrad, Anthony J. O’Donoghue, Rob Knight, Pieter C. Dorrestein

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Comprehensive proteolytic profiling of Aedes aegypti mosquito midgut extracts: Unraveling the blood meal protein digestion system. by Anthony J O'Donoghue, Chenxi Liu, Carter J Simington, Saira Montermoso, Elizabeth Moreno-Galvez, Mateus Sá M Serafim, Olive E Burata, Rachael M Lucero, James T Nguyen, Daniel Fong, Khanh Tran, Neomi Millan, Jamie M Gallimore, Kamille Parungao, Jonathan Fong, Brian M Suzuki, Zhenze Jiang, Jun Isoe, Alberto A Rascón

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