Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organization. by Véronique Brault, Patricia Pereira, Arnaud Duchon, Yann Hérault

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Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome. by Damien Marechal, Patricia Lopes Pereira, Arnaud Duchon, Yann Herault

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DYRK1A Up-Regulation Specifically Impairs a Presynaptic Form of Long-Term Potentiation by Aude-Marie Lepagnol-Bestel, Simon Haziza, Julia Viard, Paul A. Salin, Arnaud Duchon, Yann Herault, Michel Simonneau

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Deletion of the App-Runx1 region in mice models human partial monosomy 21 by Thomas Arbogast, Matthieu Raveau, Claire Chevalier, Valérie Nalesso, Doulaye Dembele, Hugues Jacobs, Olivia Wendling, Michel Roux, Arnaud Duchon, Yann Herault

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The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model. by Matthieu Raveau, Jacques M Lignon, Valérie Nalesso, Arnaud Duchon, Yoram Groner, Andrew J Sharp, Doulaye Dembele, Véronique Brault, Yann Hérault

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Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model by Chiara Lanzillotta, Monika Rataj Baniowska, Francesca Prestia, Chiara Sette, Valérie Nalesso, Marzia Perluigi, Eugenio Barone, Arnaud Duchon, Antonella Tramutola, Yann Herault, Fabio Di Domenico

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Ts66Yah, a mouse model of Down syndrome with improved construct and face validity by Arnaud Duchon, Maria del Mar Muñiz Moreno, Claire Chevalier, Valérie Nalesso, Philippe Andre, Marta Fructuoso-Castellar, Mary Mondino, Chrystelle Po, Vincent Noblet, Marie-Christine Birling, Marie-Claude Potier, Yann Herault

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Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage by Benoit Souchet, Fayçal Guedj, Ignasi Sahún, Arnaud Duchon, Fabrice Daubigney, Anne Badel, Yuchio Yanagawa, Maria Jose Barallobre, Mara Dierssen, Eugene Yu, Yann Herault, Mariona Arbones, Nathalie Janel, Nicole Créau, Jean Maurice Delabar

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Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region. by Véronique Brault, Arnaud Duchon, Caroline Romestaing, Ignasi Sahun, Stéphanie Pothion, Mona Karout, Christelle Borel, Doulaye Dembele, Jean-Charles Bizot, Nadia Messaddeq, Andrew J Sharp, Damien Roussel, Stylianos E Antonarakis, Mara Dierssen, Yann Hérault

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DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. by Christophe Noll, Chris Planque, Clémentine Ripoll, Fayçal Guedj, Anna Diez, Véronique Ducros, Nicole Belin, Arnaud Duchon, Jean-Louis Paul, Anne Badel, Bénédicte de Freminville, Yann Grattau, Henri Bléhaut, Yann Herault, Nathalie Janel, Jean-Maurice Delabar

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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A by Thu Lan Nguyen, Arnaud Duchon, Antigoni Manousopoulou, Nadège Loaëc, Benoît Villiers, Guillaume Pani, Meltem Karatas, Anna E. Mechling, Laura-Adela Harsan, Emmanuelle Limanton, Jean-Pierre Bazureau, François Carreaux, Spiros D. Garbis, Laurent Meijer, Yann Herault

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TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis by Ekaterina L. Ivanova, Johan G. Gilet, Vadym Sulimenko, Arnaud Duchon, Gabrielle Rudolf, Karen Runge, Stephan C. Collins, Laure Asselin, Loic Broix, Nathalie Drouot, Peggy Tilly, Patrick Nusbaum, Alexandre Vincent, William Magnant, Valerie Skory, Marie-Christine Birling, Guillaume Pavlovic, Juliette D. Godin, Binnaz Yalcin, Yann Hérault, Pavel Dráber, Jamel Chelly, Maria-Victoria Hinckelmann

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