Obituary Brian P. Kavanagh, MD by John C. Marshall, Arthur S. Slutsky

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Molecular mechanisms of sex bias differences in COVID-19 mortality by Yuchong Li, Mirjana Jerkic, Arthur S. Slutsky, Haibo Zhang

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Current concepts of protective ventilation during general anaesthesia by Ary Serpa Neto, Marcus J Schultz, Arthur S. Slutsky

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The Potential Protective Role of GS-441524, a Metabolite of the Prodrug Remdesivir, in Vaccine Breakthrough SARS-CoV-2 Infections by JiaYi Zhu, Yuchong Li, Jady Liang, Samira Mubareka, Arthur S. Slutsky, Haibo Zhang

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Complete countrywide mortality in COVID patients receiving ECMO in Germany throughout the first three waves of the pandemic by Christian Karagiannidis, Arthur S. Slutsky, Thomas Bein, Wolfram Windisch, Steffen Weber-Carstens, Daniel Brodie

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Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury by Dietrich Henzler, Alf Schmidt, Zhaolin Xu, Nada Ismaiel, Haibo Zhang, Arthur S. Slutsky, Paolo Pelosi

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Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury by Nada Ismaiel, Nada Ismaiel, Sara Whynot, Laurette Geldenhuys, Zhaolin Xu, Arthur S. Slutsky, Valerie Chappe, Dietrich Henzler, Dietrich Henzler

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In global health research, is it legitimate to stop clinical trials early on account of their opportunity costs? by James V Lavery, Peter A Singer, Renee Ridzon, Jerome A Singh, Arthur S Slutsky, Joseph J Anisko, David Buchanan

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Intensive care unit-acquired bacteremia in mechanically ventilated patients: clinical features and outcomes. by Hsin-Kuo Ko, Wen-Kuang Yu, Te-Cheng Lien, Jia-Horng Wang, Arthur S Slutsky, Haibo Zhang, Yu Ru Kou

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Prone position improves lung ventilation–perfusion matching in non-intubated COVID-19 patients: a prospective physiologic study by Ling Liu, Jianfeng Xie, Changsong Wang, Zhanqi Zhao, Yang Chong, Xueyan Yuan, Haibo Qiu, Mingyan Zhao, Yi Yang, Arthur S. Slutsky

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Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery by Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos, Xiao-Yan Wen

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Microarray meta-analysis identifies acute lung injury biomarkers in donor lungs that predict development of primary graft failure in recipients. by Pingzhao Hu, Xinchen Wang, Jack J Haitsma, Suleiman Furmli, Hussain Masoom, Mingyao Liu, Yumiko Imai, Arthur S Slutsky, Joseph Beyene, Celia M T Greenwood, Claudia dos Santos

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Pressure and volume limited ventilation for the ventilatory management of patients with acute lung injury: a systematic review and meta-analysis. by Karen E A Burns, Neill K J Adhikari, Arthur S Slutsky, Gordon H Guyatt, Jesus Villar, Haibo Zhang, Qi Zhou, Deborah J Cook, Thomas E Stewart, Maureen O Meade

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Anti-inflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model. by Nuria E Cabrera-Benitez, Eduardo Pérez-Roth, Milena Casula, Angela Ramos-Nuez, Carla Ríos-Luci, Carlos Rodríguez-Gallego, Ithaisa Sologuren, Virginija Jakubkiene, Arthur S Slutsky, José M Padrón, Jesús Villar

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Correction: Anti-Inflammatory Activity of a Novel Family of Aryl Ureas Compounds in an Endotoxin-Induced Airway Epithelial Cell Injury Model. by Nuria E. Cabrera-Benitez, Eduardo Pérez-Roth, Milena Casula, Ángela Ramos-Nuez, Carla Ríos-Luci, Carlos Rodríguez-Gallego, Ithaisa Sologuren, Virginija Jakubkiene, Arthur S. Slutsky, José M. Padrón, Jesús Villar

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Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection by Vanessa Monteil, Matheus Dyczynski, Volker M Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Haibo Zhang, Arthur S Slutsky, Carmen Hurtado del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi

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Efficacy of dexamethasone treatment for patients with the acute respiratory distress syndrome caused by COVID-19: study protocol for a randomized controlled superiority trial by Jesús Villar, José M. Añón, Carlos Ferrando, Gerardo Aguilar, Tomás Muñoz, José Ferreres, Alfonso Ambrós, César Aldecoa, Fernando Suárez-Sipmann, Kevin E. Thorpe, Peter Jüni, Arthur S. Slutsky, the DEXA-COVID19 Network

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Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial by Laura Amado-Rodríguez, Cecilia Del Busto, Inés López-Alonso, Diego Parra, Juan Mayordomo-Colunga, Miguel Arias-Guillén, Rodrigo Albillos-Almaraz, Paula Martín-Vicente, Cecilia López-Martínez, Covadonga Huidobro, Luigi Camporota, Arthur S. Slutsky, Guillermo M. Albaiceta

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Respiratory support in patients with acute respiratory distress syndrome: an expert opinion by Davide Chiumello, Laurent Brochard, John J. Marini, Arthur S. Slutsky, Jordi Mancebo, V. Marco Ranieri, B. Taylor Thompson, Laurent Papazian, Marcus J. Schultz, Marcelo Amato, Luciano Gattinoni, Alain Mercat, Antonio Pesenti, Daniel Talmor, Jean-Louis Vincent

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Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial by Jose Dianti, Samira Fard, Jenna Wong, Timothy C. Y. Chan, Lorenzo Del Sorbo, Eddy Fan, Marcelo B. Passos Amato, John Granton, Lisa Burry, W. Darlene Reid, Binghao Zhang, Damian Ratano, Shaf Keshavjee, Arthur S. Slutsky, Laurent J. Brochard, Niall D. Ferguson, Ewan C. Goligher

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