Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation by Shan Li, Evgeny Z. Kvon, Axel Visel, Len A. Pennacchio, Ivan Ovcharenko

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Deletion of ultraconserved elements yields viable mice. by Nadav Ahituv, Yiwen Zhu, Axel Visel, Amy Holt, Veena Afzal, Len A Pennacchio, Edward M Rubin

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Pre-hypertrophic chondrogenic enhancer landscape of limb and axial skeleton development by Fabrice Darbellay, Anna Ramisch, Lucille Lopez-Delisle, Michael Kosicki, Antonella Rauseo, Zahra Jouini, Axel Visel, Guillaume Andrey

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Tissue-specific RNA expression marks distant-acting developmental enhancers. by Han Wu, Alex S Nord, Jennifer A Akiyama, Malak Shoukry, Veena Afzal, Edward M Rubin, Len A Pennacchio, Axel Visel

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Regulatory pathway analysis by high-throughput in situ hybridization. by Axel Visel, James Carson, Judit Oldekamp, Marei Warnecke, Vladimira Jakubcakova, Xunlei Zhou, Chad A Shaw, Gonzalo Alvarez-Bolado, Gregor Eichele

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HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development by Frédéric Laurent, Ausra Girdziusaite, Julie Gamart, Iros Barozzi, Marco Osterwalder, Jennifer A. Akiyama, Joy Lincoln, Javier Lopez-Rios, Axel Visel, Aimée Zuniga, Rolf Zeller

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Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18 by Huan Liu, Kaylia Duncan, Annika Helverson, Priyanka Kumari, Camille Mumm, Yao Xiao, Jenna Colavincenzo Carlson, Fabrice Darbellay, Axel Visel, Elizabeth Leslie, Patrick Breheny, Albert J Erives, Robert A Cornell

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Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb. by Remo Monti, Iros Barozzi, Marco Osterwalder, Elizabeth Lee, Momoe Kato, Tyler H Garvin, Ingrid Plajzer-Frick, Catherine S Pickle, Jennifer A Akiyama, Veena Afzal, Niko Beerenwinkel, Diane E Dickel, Axel Visel, Len A Pennacchio

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Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors by Shiri Kult, Tsviya Olender, Marco Osterwalder, Svetalana Markman, Dena Leshkowitz, Sharon Krief, Ronnie Blecher-Gonen, Shani Ben-Moshe, Lydia Farack, Hadas Keren-Shaul, Tomer-Meir Salame, Terence D Capellini, Shalev Itzkovitz, Ido Amit, Axel Visel, Elazar Zelzer

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Genome-wide identification of bacterial plant colonization genes. by Benjamin J Cole, Meghan E Feltcher, Robert J Waters, Kelly M Wetmore, Tatiana S Mucyn, Elizabeth M Ryan, Gaoyan Wang, Sabah Ul-Hasan, Meredith McDonald, Yasuo Yoshikuni, Rex R Malmstrom, Adam M Deutschbauer, Jeffery L Dangl, Axel Visel

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Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. by Ying-Jiun J Chen, Daniel Vogt, Yanling Wang, Axel Visel, Shanni N Silberberg, Cory R Nicholas, Teruko Danjo, Joshua L Pollack, Len A Pennacchio, Stewart Anderson, Yoshiki Sasai, Scott C Baraban, Arnold R Kriegstein, Arturo Alvarez-Buylla, John L R Rubenstein

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A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2 by Marta Losa, Iros Barozzi, Marco Osterwalder, Viviana Hermosilla-Aguayo, Angela Morabito, Brandon H. Chacón, Peyman Zarrineh, Ausra Girdziusaite, Jean Denis Benazet, Jianjian Zhu, Susan Mackem, Terence D. Capellini, Diane Dickel, Nicoletta Bobola, Aimée Zuniga, Axel Visel, Rolf Zeller, Licia Selleri

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Correction to: Diel rewiring and positive selection of ancient plant proteins enabled evolution of CAM photosynthesis in Agave by Hengfu Yin, Hao-Bo Guo, David J. Weston, Anne M. Borland, Priya Ranjan, Paul E. Abraham, Sara S. Jawdy, James Wachira, Gerald A. Tuskan, Timothy J. Tschaplinski, Stan D. Wullschleger, Hong Guo, Robert L. Hettich, Stephen M. Gross, Zhong Wang, Axel Visel, Xiaohan Yang

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Diel rewiring and positive selection of ancient plant proteins enabled evolution of CAM photosynthesis in Agave by Hengfu Yin, Hao-Bo Guo, David J. Weston, Anne M. Borland, Priya Ranjan, Paul E. Abraham, Sara S. Jawdy, James Wachira, Gerald A. Tuskan, Timothy J. Tschaplinski, Stan D. Wullschleger, Hong Guo, Robert L. Hettich, Stephen M. Gross, Zhong Wang, Axel Visel, Xiaohan Yang

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Conserved enhancers control notochord expression of vertebrate Brachyury by Cassie L. Kemmler, Jana Smolikova, Hannah R. Moran, Brandon J. Mannion, Dunja Knapp, Fabian Lim, Anna Czarkwiani, Viviana Hermosilla Aguayo, Vincent Rapp, Olivia E. Fitch, Seraina Bötschi, Licia Selleri, Emma Farley, Ingo Braasch, Maximina Yun, Axel Visel, Marco Osterwalder, Christian Mosimann, Zbynek Kozmik, Alexa Burger

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Long-read metagenomics of soil communities reveals phylum-specific secondary metabolite dynamics by Marc W. Van Goethem, Andrew R. Osborn, Benjamin P. Bowen, Peter F. Andeer, Tami L. Swenson, Alicia Clum, Robert Riley, Guifen He, Maxim Koriabine, Laura Sandor, Mi Yan, Chris G. Daum, Yuko Yoshinaga, Thulani P. Makhalanyane, Ferran Garcia-Pichel, Axel Visel, Len A. Pennacchio, Ronan C. O’Malley, Trent R. Northen

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Genome-wide compendium and functional assessment of in vivo heart enhancers by Diane E. Dickel, Iros Barozzi, Yiwen Zhu, Yoko Fukuda-Yuzawa, Marco Osterwalder, Brandon J. Mannion, Dalit May, Cailyn H. Spurrell, Ingrid Plajzer-Frick, Catherine S. Pickle, Elizabeth Lee, Tyler H. Garvin, Momoe Kato, Jennifer A. Akiyama, Veena Afzal, Ah Young Lee, David U. Gorkin, Bing Ren, Edward M. Rubin, Axel Visel, Len A. Pennacchio

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Plant single-cell solutions for energy and the environment by Benjamin Cole, Dominique Bergmann, Crysten E. Blaby-Haas, Ian K. Blaby, Kristofer E. Bouchard, Siobhan M. Brady, Doina Ciobanu, Devin Coleman-Derr, Samuel Leiboff, Jenny C. Mortimer, Tatsuya Nobori, Seung Y. Rhee, Jeremy Schmutz, Blake A. Simmons, Anup K. Singh, Neelima Sinha, John P. Vogel, Ronan C. O’Malley, Axel Visel, Diane E. Dickel

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Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice by Jessica L. Haigh, Anna Adhikari, Nycole A. Copping, Tyler Stradleigh, A. Ayanna Wade, Rinaldo Catta-Preta, Linda Su-Feher, Iva Zdilar, Sarah Morse, Timothy A. Fenton, Anh Nguyen, Diana Quintero, Samrawit Agezew, Michael Sramek, Ellie J. Kreun, Jasmine Carter, Andrea Gompers, Jason T. Lambert, Cesar P. Canales, Len A. Pennacchio, Axel Visel, Diane E. Dickel, Jill L. Silverman, Alex S. Nord

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High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene by Fedik Rahimov, Pekka Nieminen, Priyanka Kumari, Emma Juuri, Tiit Nikopensius, Kitt Paraiso, Jakob German, Antti Karvanen, Mart Kals, Abdelrahman G. Elnahas, Juha Karjalainen, Mitja Kurki, Aarno Palotie, FinnGen, Estonian Biobank Research Team, Arja Heliövaara, Tõnu Esko, Sakari Jukarainen, Priit Palta, Andrea Ganna, Anjali P. Patni, Daniel Mar, Karol Bomsztyk, Julie Mathieu, Hannele Ruohola-Baker, Axel Visel, Walid D. Fakhouri, Brian C. Schutte, Robert A. Cornell, David P. Rice

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