Understanding the use of observational and randomized data in cardiovascular medicine by Bowman, L, Baras, A, Bombien, R, Califf, RM, Chen, Z, Gale, CP, Gaziano, JM, Grobbee, DE, Maggioni, AP, Muse, ED, Roden, DM, Schroeder, S, Wallentin, L, Casadei, B

Rare protein-truncating variants in APOB, lower low-density lipoprotein cholesterol, and protection against coronary heart disease by Peloso, G, Nomura, A, Khera, A, Chaffin, M, Won, H, Ardissino, D, Danesh, J, Schunkert, H, Wilson, J, Samani, N, Erdmann, J, McPherson, R, Watkins, H, Saleheen, D, McCarthy, S, Teslovich, T, Leader, J, Kirchner, H, Marrugat, J, Nohara, A, Kawashiri, M, Tada, H, Dewey, F, Carey, D, Baras, A, Kathiresan, S

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion by Dwivedi, O, Lehtovirta, M, Hastoy, B, Chandra, V, Krentz, N, Kleiner, S, Jain, D, Richard, A, Abaitua, F, Beer, N, Grotz, A, Prasad, R, Hansson, O, Ahlqvist, E, Krus, U, Artner, I, Suoranta, A, Gomez, D, Baras, A, Champon, B, Payne, A, Moralli, D, Thomsen, S, Kramer, P, Spiliotis, I, Ramracheya, R, Chabosseau, P, Theodoulou, A, Cheung, R, Van De Bunt, M, Flannick, J, Trombetta, M, Bonora, E, Wolheim, C, Sarelin, L, Bonadonna, R, Rorsman, P, Davies, B, Brosnan, J, McCarthy, M, Otonkoski, T, Lagerstedt, J, Rutter, G, Gromada, J, Gloyn, A, Tuomi, T, Groop, L

A deep catalogue of protein-coding variation in 983,578 individuals by Sun, KY, Bai, X, Chen, S, Bao, S, Zhang, C, Kapoor, M, Backman, J, Joseph, T, Maxwell, E, Mitra, G, Gorovits, A, Mansfield, A, Boutkov, B, Gokhale, S, Habegger, L, Marcketta, A, Locke, AE, Ganel, L, Hawes, A, Kessler, MD, Sharma, D, Staples, J, Bovijn, J, Gelfman, S, Di Gioia, A, Rajagopal, VM, Lopez, A, Varela, JR, Alegre, J, Berumen, J, Tapia-Conyer, R, Kuri-Morales, P, Torres, J, Emberson, J, Collins, R, Regeneron Genetics Center, RGC-ME Cohort Partners, Cantor, M, Thornton, T, Kang, HM, Overton, JD, Shuldiner, AR, Cremona, ML, Nafde, M, Baras, A, Abecasis, G, Marchini, J, Reid, JG, Salerno, W, Balasubramanian, S

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility by Sazonovs, A, Stevens, CR, Venkataraman, GR, Yuan, K, Avila, B, Abreu, MT, Ahmad, T, Allez, M, Ananthakrishnan, AN, Atzmon, G, Baras, A, Barrett, JC, Barzilai, N, Beaugerie, L, Beecham, A, Bernstein, CN, Bitton, A, Bokemeyer, B, Chan, A, Chung, D, Cleynen, I, Cosnes, J, Cutler, DJ, Daly, A, Damas, OM, Datta, LW, Dawany, N, Devoto, M, Dodge, S, Ellinghaus, E, Fachal, L, Farkkila, M, Faubion, W, Ferreira, M, Franchimont, D, Gabriel, SB, Ge, T, Georges, M, Gettler, K, Giri, M, Glaser, B, Goerg, S, Goyette, P, Graham, D, Hämäläinen, E, Haritunians, T, Heap, GA, Hiltunen, M, Hoeppner, M, Horowitz, JE, Simmons, A, Uhlig, HH

Genotyping, sequencing and analysis of 140,000 adults from Mexico City by Ziyatdinov, A, Torres, J, Alegre-Díaz, J, Backman, J, Mbatchou, J, Turner, M, Gaynor, SM, Joseph, T, Zou, Y, Liu, D, Wade, R, Staples, J, Panea, R, Popov, A, Bai, X, Balasubramanian, S, Habegger, L, Lanche, R, Lopez, A, Maxwell, E, Jones, M, García-Ortiz, H, Ramirez-Reyes, R, Santacruz-Benítez, R, Nag, A, Smith, KR, Damask, A, Lin, N, Paulding, C, Reppell, M, Zöllner, S, Jorgenson, E, Salerno, W, Petrovski, S, Overton, J, Reid, J, Thornton, TA, Abecasis, G, Berumen, J, Orozco-Orozco, L, Collins, R, Baras, A, Hill, MR, Emberson, JR, Marchini, J, Kuri-Morales, P, Tapia-Conyer, R

Whole-genome sequencing reveals host factors underlying critical COVID-19 by Kousathanas, A, Pairo-Castineira, E, Rawlik, K, Stuckey, A, Odhams, CA, Walker, S, Russell, CD, Malinauskas, T, Wu, Y, Millar, J, Shen, X, Elliott, KS, Griffiths, F, Oosthuyzen, W, Morrice, K, Keating, S, Wang, B, Rhodes, D, Klaric, L, Zechner, M, Parkinson, N, Siddiq, A, Goddard, P, Donovan, S, Maslove, D, Nichol, A, Semple, MG, Zainy, T, Maleady-Crowe, F, Todd, L, Salehi, S, Knight, J, Elgar, G, Chan, G, Arumugam, P, Patch, C, Rendon, A, Bentley, D, Kingsley, C, Kosmicki, JA, Horowitz, JE, Baras, A, Abecasis, GR, Ferreira, MAR, Justice, A, Mirshahi, T, Oetjens, M, Rader, DJ, Ritchie, MD, Verma, A, Horby, P, Ling, L, McAuley, D, Montgomery, H, Openshaw, PJM, Elliott, P, Walsh, T, Tenesa, A, Fawkes, A, Murphy, L, Rowan, K, Ponting, CP, Vitart, V, Wilson, JF, Yang, J, Bretherick, AD, Scott, RH, Hendry, SC, Moutsianas, L, Law, A, Caulfield, MJ, Baillie, JK

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes by Gusarova, V, O'Dushlaine, C, Teslovich, TM, Benotti, PN, Mirshahi, T, Gottesman, O, Van Hout, CV, Murray, MF, Mahajan, A, Nielsen, JB, Fritsche, L, Wulff, AB, Gudbjartsson, DF, Sjögren, M, Emdin, CA, Scott, RA, Lee, W-J, Small, A, Kwee, LC, Dwivedi, OP, Prasad, RB, Bruse, S, Lopez, AE, Penn, J, Marcketta, A, Leader, JB, Still, CD, Kirchner, HL, Mirshahi, UL, Wardeh, AH, Hartle, CM, Habegger, L, Fetterolf, SN, Tusie-Luna, T, Morris, AP, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, JI, Chuang, L-M, Damrauer, S, Birtwell, D, Brummett, CM, Khera, AV, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, LA, Willer, CJ, Holmen, OL, Ritchie, MD, Ledbetter, DH, Murphy, AJ, Borecki, IB, Reid, JG, Overton, JD, Hansson, O, Groop, L, Shah, SH, Kraus, WE, Rader, DJ, Chen, Y-DI, Hveem, K, Wareham, NJ, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, BG, Tybjærg-Hansen, A, Abecasis, GR, Altshuler, D, Florez, JC, Boehnke, M, McCarthy, MI, Yancopoulos, GD, Carey, DJ, Shuldiner, AR, Baras, A, Dewey, FE, Gromada, J

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls by Flannick, J, Mercader, JM, Fuchsberger, C, Udler, MS, Mahajan, A, Wessel, J, Teslovich, TM, Caulkins, L, Koesterer, R, Barajas-Olmos, F, Blackwell, TW, Boerwinkle, E, Brody, JA, Centeno-Cruz, F, Chen, L, Chen, S, Contreras-Cubas, C, Córdova, E, Correa, A, Cortes, M, Defronzo, RA, Dolan, L, Drews, KL, Elliott, A, Floyd, JS, Gabriel, S, Garay-Sevilla, ME, García-Ortiz, H, Gross, M, Han, S, Heard-Costa, NL, Jackson, AU, Jørgensen, ME, Kang, HM, Kelsey, M, Kim, B-J, Koistinen, HA, Kuusisto, J, Leader, JB, Linneberg, A, Liu, C-T, Liu, J, Lyssenko, V, Manning, AK, Marcketta, A, Malacara-Hernandez, JM, Martínez-Hernández, A, Matsuo, K, Mayer-Davis, E, Mendoza-Caamal, E, Mohlke, KL, Morrison, AC, Ndungu, A, Ng, MCY, O'Dushlaine, C, Payne, AJ, Pihoker, C, Post, WS, Preuss, M, Psaty, BM, Vasan, RS, Rayner, NW, Reiner, AP, Revilla-Monsalve, C, Robertson, NR, Santoro, N, Schurmann, C, So, WY, Soberón, X, Stringham, HM, Strom, TM, Tam, CHT, Thameem, F, Tomlinson, B, Torres, JM, Tracy, RP, Van Dam, RM, Vujkovic, M, Wang, S, Welch, RP, Witte, DR, Wong, T-Y, Atzmon, G, Barzilai, N, Blangero, J, Bonnycastle, LL, Bowden, DW, Chambers, JC, Chan, E, Cheng, C-Y, Cho, YS, Collins, FS, De Vries, PS, Duggirala, R, Glaser, B, Gonzalez, C, Gonzalez, ME, Groop, L, Kooner, JS, Kwak, SH, Laakso, M, Lehman, DM, Nilsson, P, Spector, TD, Tai, ES, Tuomi, T, Tuomilehto, J, Wilson, JG, Aguilar-Salinas, CA, Bottinger, E, Burke, B, Carey, DJ, Chan, JCN, Dupuis, J, Frossard, P, Heckbert, SR, Hwang, MY, Kim, YJ, Kirchner, HL, Lee, J-Y, Lee, J, Loos, RJF, Ma, RCW, Morris, AD, O'Donnell, CJ, Palmer, CNA, Pankow, J, Park, KS, Rasheed, A, Saleheen, D, Sim, X, Small, KS, Teo, YY, Haiman, C, Hanis, CL, Henderson, BE, Orozco, L, Tusié-Luna, T, Dewey, FE, Baras, A, Gieger, C, Meitinger, T, Strauch, K, Lange, L, Grarup, N, Hansen, T, Pedersen, O, Zeitler, P, Dabelea, D, Abecasis, G, Bell, GI, Cox, NJ, Seielstad, M, Sladek, R, Meigs, JB, Rich, SS, Rotter, JI, Altshuler, D, Burtt, NP, Scott, LJ, Morris, AP, Florez, JC, McCarthy, MI, Boehnke, M, CHARGE