Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide door Chowdhury, O, O’Sullivan, J, Barkas, N, Wang, G, Buck, G, Hamblin, A

A single-cell approach to unraveling abnormal megakaryocyte differentiation and function in myelofibrosis door Psaila, B, Heuston, E, Milojkovic, D, Lichtenberg, J, Anderson, S, Hoffman, R, Roberts, I, Mead, A, Bodine, D, Barkas, N, Progra, N

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways door Psaila, B, Barkas, N, Iskander, D, Roy, A, Anderson, S, Ashley, N, Caputo, V, Lichtenberg, J, Loaiza, S, Bodine, D, Karadimitris, A, Mead, A, Roberts, I

Unravelling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA sequencing door Rodriguez-Meira, A, Buck, G, Clark, S, Povinelli, B, Alcolea, V, Louka, E, McGowan, S, Hamblin, A, Sousos, N, Barkas, N, Giustacchini, A, Psaila, B, Jacobsen, S, Thongjuea, S, Mead, A

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation door Mead, A, Neo, W, Barkas, N, Matsuoka, S, Giustacchini, A, Facchini, R, Thongjuea, S, Jamieson, L, Booth, C, Fordham, N, Di Genua, C, Atkinson, D, Chowdhury, O, Repapi, E, Gray, N, Kharazi, S, Clark, S, Bouriez, T, Woll, P, Suda, T, Nerlov, C, Jacobsen, S

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia door Giustacchini, A, Thongjuea, S, Barkas, N, Woll, P, Povinelli, B, Booth, C, Sopp, P, Norfo, R, Rodriguez-Meira, A, Ashley, N, Jamieson, L, Vyas, P, Anderson, K, Segerstolpe, Å, Qian, H, Olsson-Strömberg, U, Mustjoki, S, Sandberg, R, Jacobsen, S, Mead, A

Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors door Booth, CAG, Barkas, N, Neo, WH, Boukarabila, H, Soilleux, EJ, Giotopoulos, G, Farnoud, N, Giustacchini, A, Ashley, N, Carrelha, J, Jamieson, L, Atkinson, D, Bouriez-Jones, T, Prinjha, RK, Milne, TA, Teachey, DT, Papaemmanuil, E, Huntly, BJP, Jacobsen, SEW, Mead, AJ

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner door Luis, TC, Barkas, N, Carrelha, J, Giustacchini, A, Mazzi, S, Norfo, R, Wu, B, Aliouat, A, Guerrero, JA, Rodriguez-Meira, A, Bouriez-Jones, T, Macaulay, IC, Jasztal, M, Zhu, G, Ni, H, Robson, MJ, Blakely, RD, Mead, AJ, Nerlov, C, Ghevaert, C, Jacobsen, SEW

Spliceosome mutations are common in MPN-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide door Chowdhury, O, O'Sullivan, J, Barkas, N, Buck, G, Hamblin, A, Tefferi, A, Al-Ali, H, Barosi, G, Devos, T, Gisslinger, H, Jiang, Q, Kiladjian, J, Mesa, R, Passamonti, F, Ribrag, V, Schiller, G, Vannucchi, A, Zhou, D, McMullin, M, Reiser, D, Zhong, J, Gale, R, Mead, A