Editorial: Understanding the Cytokine Release Syndrome: Toward Improving Cancer Immunotherapy by Beatriz Martín-Antonio

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Editorial: Expert opinions and perspectives in adoptive cell therapy for cancer: 2022 by Beatriz Martín-Antonio

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Inflammaging, an Imbalanced Immune Response That Needs to Be Restored for Cancer Prevention and Treatment in the Elderly by Juana Serrano-López, Beatriz Martín-Antonio

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104 BCMA-targeting CAR-T cells expanded in IL-15 have an improved phenotype for therapeutic use compared to those grown in IL-2 or IL-15/IL-7 by Anthony Battram, Alvaro Urbano-Ispizua, Beatriz Martín-Antonio, Mireia Bachiller

Tumor Secretome to Adoptive Cellular Immunotherapy: Reduce Me Before I Make You My Partner by Mikel Etxebeste-Mitxeltorena, Inés del Rincón-Loza, Beatriz Martín-Antonio

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CAR-T Cell Therapy: A Door Is Open to Find Innumerable Possibilities of Treatments for Cancer Patients by Lorena Perez - Amill, Berta Marzal, Alvaro Urbano - Ispizua, Manel Juan, Beatriz Martín - Antonio

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Impact of constitutional polymorphisms in VCAM1 and CD44 on CD34+ cell collection yield after administration of granulocyte colony-stimulating factor to healthy donors by Beatriz Martín-Antonio, Magdalena Carmona, Jose Falantes, Encarnación Gil, Alicia Baez, María Suarez, Pedro Marín, Ildefonso Espigado, Álvaro Urbano-Ispizua

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NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness by Amer Najjar, Manel Juan, Lorena Pérez-Amill, Alvaro Urbano-Ispizua, Beatriz Martín-Antonio, Mireia Bachiller, Anthony Matthew Battram, Sebastian Ciro Carné, Els Verhoeyen

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Granulocyte colony-stimulating factor produces long-term changes in gene and microRNA expression profiles in CD34+ cells from healthy donors by Alicia Báez, Beatriz Martín-Antonio, José I. Piruat, Concepción Prats, Isabel Álvarez-Laderas, M. Victoria Barbado, Magdalena Carmona, Álvaro Urbano-Ispizua, Jose Antonio Pérez-Simón

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Preclinical development of a humanized chimeric antigen receptor against B cell maturation antigen for multiple myeloma by Lorena Perez-Amill, Guillermo Suñe, Asier Antoñana-Vildosola, Maria Castella, Amer Najjar, Jaume Bonet, Narcis Fernández-Fuentes, Susana Inogés, Ascensión López, Clara Bueno, Manel Juan, Álvaro Urbano-Ispizua, Beatriz Martín-Antonio

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Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease by Clara Bueno, Mar Roldan, Eduardo Anguita, Damia Romero-Moya, Beatriz Martín-Antonio, Michael Rosu-Myles, Consuelo del Cañizo, Francisco Campos, Regina García, Maite Gómez-Casares, Jose Luis Fuster, Manuel Jurado, Mario Delgado, Pablo Menendez

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Preclinical development of three novel CARs targeting CD79b for the treatment of non-Hodgkin’s lymphoma and characterization of the loss of the target antigen by Manel Juan, Beatriz Martín-Antonio, Pablo Engel, Narcis Fernandez-Fuentes, Esperanza Esquinas, Alvaro Moreno-Sanz, Victor Sandá, Damian Stodulski-Ciesla, Jennifer Borregón, Virginia Peña-Blanque, Javier Fernández-Calles, Juana Serrano-Lopez, Pilar Llamas-Sillero, Laura Solán-Blanco

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S256: HLA-E/NKG2A CHECKPOINT DRIVES MULTIPLE MYELOMA RESISTANCE TO CAR-NK THERAPY by Jessica Encinas, Almudena García-Ortiz, Elena Maroto-Martín, Eva Castellano, Raquel Oliva, Rafael Alonso Fernández, Maria Teresa Cedena Romero, Alejandra Leivas, Beatriz Martín-Antonio, Guillermo Suñe, Dean A. Lee, Daniel J. Powell, Jr., Paula Río, Joaquín Martinez-Lopez, Antonio Valeri

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Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion by Joan Isern, Beatriz Martín-Antonio, Roshanak Ghazanfari, Ana M. Martín, Juan A. López, Raquel del Toro, Abel Sánchez-Aguilera, Lorena Arranz, Daniel Martín-Pérez, María Suárez-Lledó, Pedro Marín, Melissa Van Pel, Willem E. Fibbe, Jesús Vázquez, Stefan Scheding, Álvaro Urbano-Ispizúa, Simón Méndez-Ferrer

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Gene Expression Analysis of the Bone Marrow Microenvironment Reveals Distinct Immunotypes in Smoldering Multiple Myeloma Associated to Progression to Symptomatic Disease by Ignacio Isola, Fara Brasó-Maristany, David F. Moreno, Mari-Pau Mena, Aina Oliver-Calders, Laia Paré, Luis Gerardo Rodríguez-Lobato, Beatriz Martin-Antonio, María Teresa Cibeira, Joan Bladé, Laura Rosiñol, Aleix Prat, Ester Lozano, Ester Lozano, Carlos Fernández de Larrea, Carlos Fernández de Larrea

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Choosing T-cell sources determines CAR-T cell activity in neuroblastoma by Lorena García-García, Lorena García-García, Elena G. Sánchez, Elena G. Sánchez, Mariya Ivanova, Mariya Ivanova, Keren Pastora, Keren Pastora, Cristina Alcántara-Sánchez, Cristina Alcántara-Sánchez, Jorge García-Martínez, Jorge García-Martínez, Beatriz Martín-Antonio, Manuel Ramírez, Manuel Ramírez, Manuel Ramírez, África González-Murillo, África González-Murillo, África González-Murillo

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Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial by Maria Castella, Maria Castella, Maria Castella, Miguel Caballero-Baños, Miguel Caballero-Baños, Valentín Ortiz-Maldonado, Europa Azucena González-Navarro, Guillermo Suñé, Guillermo Suñé, Asier Antoñana-Vidósola, Asier Antoñana-Vidósola, Anna Boronat, Anna Boronat, Berta Marzal, Lucía Millán, Beatriz Martín-Antonio, Beatriz Martín-Antonio, Joan Cid, Joan Cid, Miquel Lozano, Miquel Lozano, Enric García, Enric García, Jaime Tabera, Jaime Tabera, Esteve Trias, Unai Perpiña, Josep Ma Canals, Josep Ma Canals, Josep Ma Canals, Tycho Baumann, Daniel Benítez-Ribas, Daniel Benítez-Ribas, Elías Campo, Elías Campo, Elías Campo, Elías Campo, Elías Campo, Jordi Yagüe, Jordi Yagüe, Jordi Yagüe, Álvaro Urbano-Ispizua, Álvaro Urbano-Ispizua, Álvaro Urbano-Ispizua, Álvaro Urbano-Ispizua, Álvaro Urbano-Ispizua, Susana Rives, Susana Rives, Julio Delgado, Julio Delgado, Julio Delgado, Julio Delgado, Manel Juan, Manel Juan, Manel Juan, Manel Juan, Manel Juan, Manel Juan

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A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms by Carolina Martínez-Laperche, Elena Buces, M. Carmen Aguilera-Morillo, Antoni Picornell, Milagros González-Rivera, Rosa Lillo, Nazly Santos, Beatriz Martín-Antonio, Vicent Guillem, José B. Nieto, Marcos González, Rafael de la Cámara, Salut Brunet, Antonio Jiménez-Velasco, Ildefonso Espigado, Carlos Vallejo, Antonia Sampol, José María Bellón, David Serrano, Mi Kwon, Jorge Gayoso, Pascual Balsalobre, Álvaro Urbano-Izpizua, Carlos Solano, David Gallardo, José Luis Díez-Martín, Juan Romo, Ismael Buño

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Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations by Beatriz Martín-Antonio, Belén Blanco, África González-Murillo, Laura Hidalgo, Jordi Minguillón, Gema Pérez-Chacón, Next Generation CART MAD Consortium, Jordi Minguillón, Lucía Fernández, Halin Bareke, Andrés París-Muñoz, Adriana Mañas, Cristina Aguirre-Portolés, Alfonso Navarro-Zapata, Carmen Mestre-Durán, Marta Ibáñez-Navarro, Laura Clares-Villa, Sara Naharro, Antonio Perez-Martinez, Marcos Aldea, María Gaibar, Javier Ruiz-Navarro, Manuel Izquierdo, Juan M. Zapata, África González Murillo, Elena García Sánchez, Jorge García Martínez, Alba Rubio San Simón, Blanca Herrero, Gonzalo García Aguilera, Beatriz Horcajo Morera, Manuel Ramírez Orellana, Belén Blanco-Durango, Anais Jiménez-Reinoso, Rodrigo Lázaro-Gorines, Ivana Zagorac, Antonio Tapia Galisteo, Ángel Ramirez-Fernández, Laura Díez-Alonso, Carmen Dominguez-Alonso, Ainhoa Erce-Llamazares, Oana Hangiu, Laura Rubio Pérez, Marina Gómez Rosel, Alejandro Segura Tudela, Javier Arroyo-Ródena, Luis Álvarez-Vallina, Miguel Ángel Rodríguez Milla, Patricia García Rodríguez, Beatriz Somovilla Crespo, Javier García-Castro, Esperanza Esquinas Tarifa, Juana Serrano-López, Pilar Llamas-Sillero, Beatriz Martin-Antonio

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Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions by Maria Castella, Anna Boronat, Raquel Martín-Ibáñez, Vanina Rodríguez, Guillermo Suñé, Miguel Caballero, Berta Marzal, Lorena Pérez-Amill, Beatriz Martín-Antonio, Julio Castaño, Clara Bueno, Olga Balagué, Europa Azucena González-Navarro, Carles Serra-Pages, Pablo Engel, Ramon Vilella, Daniel Benitez-Ribas, Valentín Ortiz-Maldonado, Joan Cid, Jaime Tabera, Josep M. Canals, Miquel Lozano, Tycho Baumann, Anna Vilarrodona, Esteve Trias, Elías Campo, Pablo Menendez, Álvaro Urbano-Ispizua, Jordi Yagüe, Patricia Pérez-Galán, Susana Rives, Julio Delgado, Manel Juan

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