Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase. by Champness, J, Stammers, D, Beddell, C

Species differences in the binding of compounds designed to fit a site of known structure in adult human haemoglobin. by Beddell, C, Goodford, P, Stammers, D, Wootton, R

Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim. by Kuyper, L, Garvey, J, Baccanari, D, Champness, J, Stammers, D, Beddell, C

The binding of trimethoprim to bacterial dihydrofolate reductase. by Baker, D, Beddell, C, Champness, J, Goodford, P, Norrington, F, Smith, DR, Stammers, D

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme. by Stammers, D, Champness, J, Beddell, C, Dann, J, Eliopoulos, E, Geddes, A, Ogg, D, North, A

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted tr... by Kuyper, L, Roth, B, Baccanari, D, Ferone, R, Beddell, C, Champness, J, Stammers, D, Dann, J, Norrington, F, Baker, D

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. by Matthews, D, Bolin, J, Burridge, J, Filman, D, Volz, K, Kaufman, B, Beddell, C, Champness, J, Stammers, D, Kraut, J

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted tr... by Kuyper, L, Roth, B, Baccanari, D, Ferone, R, Beddell, C, Champness, J, Stammers, D, Dann, J, Norrington, F, Baker, D, Goodford, P