Breaking barriers in antibody discovery: harnessing divergent species for accessing difficult and conserved drug targets by Soma S.R. Banik, Natasha Kushnir, Benjamin J. Doranz, Ross Chambers

Get full text

Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. by Tiffani A Greene, Suzanne Alarcon, Anu Thomas, Eli Berdougo, Benjamin J Doranz, Paul A S Breslin, Joseph B Rucker

Get full text

The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket by Anu Thomas, Chidananda Sulli, Edgar Davidson, Eli Berdougo, Morganne Phillips, Bridget A. Puffer, Cheryl Paes, Benjamin J. Doranz, Joseph B. Rucker

Get full text

A Biologically-validated HCV E1E2 Heterodimer Structural Model by Matteo Castelli, Nicola Clementi, Jennifer Pfaff, Giuseppe A. Sautto, Roberta A. Diotti, Roberto Burioni, Benjamin J. Doranz, Matteo Dal Peraro, Massimo Clementi, Nicasio Mancini

Get full text

Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins. by Jarrod J Mousa, Elad Binshtein, Stacey Human, Rachel H Fong, Gabriela Alvarado, Benjamin J Doranz, Martin L Moore, Melanie D Ohi, James E Crowe

Get full text

Dengue reporter virus particles for measuring neutralizing antibodies against each of the four dengue serotypes. by Kimberly Mattia, Bridget A Puffer, Katherine L Williams, Ritela Gonzalez, Meredith Murray, Emily Sluzas, Dan Pagano, Sandya Ajith, Megan Bower, Eli Berdougo, Eva Harris, Benjamin J Doranz

Get full text

Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis. by Radhika Gopal, Kelli Jackson, Netanel Tzarum, Leopold Kong, Andrew Ettenger, Johnathan Guest, Jennifer M Pfaff, Trevor Barnes, Andrew Honda, Erick Giang, Edgar Davidson, Ian A Wilson, Benjamin J Doranz, Mansun Law

Get full text

Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein. by Mark D Hicar, Xuemin Chen, Chidananda Sulli, Trevor Barnes, Jason Goodman, Hakimuddin Sojar, Bryan Briney, Jordan Willis, Valentine U Chukwuma, Spyros A Kalams, Benjamin J Doranz, Paul Spearman, James E Crowe

Get full text

An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with in vivo therapeutic potency by Tomohiro Kotaki, Takeshi Kurosu, Ariadna Grinyo-Escuer, Edgar Davidson, Siti Churrotin, Tamaki Okabayashi, Orapim Puiprom, Kris Cahyo Mulyatno, Teguh Hari Sucipto, Benjamin J. Doranz, Ken-ichiro Ono, Soegeng Soegijanto, Masanori Kameoka

Get full text

Antigenicity, stability, and reproducibility of Zika reporter virus particles for long-term applications. by J Charles Whitbeck, Anu Thomas, Kathryn Kadash-Edmondson, Ariadna Grinyo-Escuer, Lewis J Stafford, Celine Cheng, Grant C Liao, Frederick W Holtsberg, M Javad Aman, Graham Simmons, Edgar Davidson, Benjamin J Doranz

Get full text

Antigenicity, stability, and reproducibility of Zika reporter virus particles for long-term applications by J. Charles Whitbeck, Anu Thomas, Kathryn Kadash-Edmondson, Ariadna Grinyo-Escuer, Lewis J. Stafford, Celine Cheng, Grant C. Liao, Frederick W. Holtsberg, M. Javad Aman, Graham Simmons, Edgar Davidson, Benjamin J. Doranz, Aaron C. Brault

Get full text

Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes. by Leike Li, Weixu Meng, Melanie Horton, Daniel R DiStefano, Elizabeth A Thoryk, Jennifer M Pfaff, Qihui Wang, Georgina T Salazar, Trevor Barnes, Benjamin J Doranz, Andrew J Bett, Danilo R Casimiro, Kalpit A Vora, Zhiqiang An, Ningyan Zhang

Get full text

The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein by Scott A. Smith, A. Ruklanthi de Alwis, Nurgun Kose, Eva Harris, Kristie D. Ibarra, Kristen M. Kahle, Jennifer M. Pfaff, Xiaoxiao Xiang, Benjamin J. Doranz, Aravinda M. de Silva, S. Kyle Austin, Soila Sukupolvi-Petty, Michael S. Diamond, James E. Crowe

Get full text

Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis by Jing Jin, Nathan M. Liss, Dong-Hua Chen, Maofu Liao, Julie M. Fox, Raeann M. Shimak, Rachel H. Fong, Daniel Chafets, Sonia Bakkour, Sheila Keating, Marina E. Fomin, Marcus O. Muench, Michael B. Sherman, Benjamin J. Doranz, Michael S. Diamond, Graham Simmons

Get full text

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus by Katie A. Howell, Jennifer M. Brannan, Christopher Bryan, Andrew McNeal, Edgar Davidson, Hannah L. Turner, Hong Vu, Sergey Shulenin, Shihua He, Ana Kuehne, Andrew S. Herbert, Xiangguo Qiu, Benjamin J. Doranz, Frederick W. Holtsberg, Andrew B. Ward, John M. Dye, M. Javad Aman

Get full text

Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth. by Valentine U Chukwuma, Nurgun Kose, D Noah Sather, Gopal Sapparapu, Rachel Falk, Hannah King, Vidisha Singh, Rebecca Lampley, Delphine C Malherbe, Noah T Ditto, Jonathan T Sullivan, Trevor Barnes, Benjamin J Doranz, Celia C Labranche, David C Montefiori, Spyros A Kalams, Nancy L Haigwood, James E Crowe

Get full text

Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies by Charles D. Murin, Pavlo Gilchuk, Philipp A. Ilinykh, Kai Huang, Natalia Kuzmina, Xiaoli Shen, Jessica F. Bruhn, Aubrey L. Bryan, Edgar Davidson, Benjamin J. Doranz, Lauren E. Williamson, Jeffrey Copps, Tanwee Alkutkar, Andrew I. Flyak, Alexander Bukreyev, James E. Crowe, Jr., Andrew B. Ward

Get full text

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses. by Jay Lubow, Lisa M Levoir, Duncan K Ralph, Laura Belmont, Maya Contreras, Catiana H Cartwright-Acar, Caroline Kikawa, Shruthi Kannan, Edgar Davidson, Veronica Duran, David E Rebellon-Sanchez, Ana M Sanz, Fernando Rosso, Benjamin J Doranz, Shirit Einav, Frederick A Matsen Iv, Leslie Goo

Get full text

Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics by Natasha D Durham, Aditi Agrawal, Eric Waltari, Derek Croote, Fabio Zanini, Mallorie Fouch, Edgar Davidson, Olivia Smith, Esteban Carabajal, John E Pak, Benjamin J Doranz, Makeda Robinson, Ana M Sanz, Ludwig L Albornoz, Fernando Rosso, Shirit Einav, Stephen R Quake, Krista M McCutcheon, Leslie Goo

Get full text

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape by Zhiqiang Ku, Xuping Xie, Edgar Davidson, Xiaohua Ye, Hang Su, Vineet D. Menachery, Yize Li, Zihao Yuan, Xianwen Zhang, Antonio E. Muruato, Ariadna Grinyo i Escuer, Breanna Tyrell, Kyle Doolan, Benjamin J. Doranz, Daniel Wrapp, Paul F. Bates, Jason S. McLellan, Susan R. Weiss, Ningyan Zhang, Pei-Yong Shi, Zhiqiang An

Get full text