Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni by Valérian Pasche, Benoît Laleu, Jennifer Keiser

Get full text

Actives from MMV Open Access Boxes? A suggested way forward. by Kirandeep Samby, Paul A Willis, Jeremy N Burrows, Benoît Laleu, Peter J H Webborn

Get full text

Oxidative stress changes the effectiveness of artemisinin in Plasmodium falciparum by Camilla Valente Pires, Debora Cassandra, Shulin Xu, Benoit Laleu, Jeremy N. Burrows, John H. Adams

Get full text

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates by Jian Liang Low, Mu-Lu Wu, Dinah Binte Aziz, Benoît Laleu, Thomas Dick, Thomas Dick

Get full text

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development. by Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar, Abhishek Dusane, Benoît Laleu, Valeria Bellini, Mohamed-Ali Hakimi, Alexandre Bougdour, Amit Sharma

Get full text

Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm by Sarah Preston, Yaqing Jiao, Abdul Jabbar, Sean L. McGee, Benoît Laleu, Paul Willis, Timothy N.C. Wells, Robin B. Gasser

Get full text

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis by Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra, Jyoti Chhibber-Goel, Valeria Bellini, Karl Harlos, Benoît Laleu, Mohamed-Ali Hakimi, Amit Sharma

Get full text

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. by Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra, Jyoti Chhibber-Goel, Valeria Bellini, Karl Harlos, Benoît Laleu, Mohamed-Ali Hakimi, Amit Sharma

Get full text

Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. by Wilson Lim, Youri Melse, Mickey Konings, Hung Phat Duong, Kimberly Eadie, Benoît Laleu, Benjamin Perry, Matthew H Todd, Jean-Robert Ioset, Wendy W J van de Sande

Get full text

Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of <i>Trypanosoma brucei brucei</i> by Darline Dize, Rolland Bantar Tata, Rodrigue Keumoe, Rufin Marie Kouipou Toghueo, Mariscal Brice Tchatat, Cyrille Ngansop Njanpa, Vianey Claire Tchuenguia, Lauve Tchokouaha Yamthe, Patrick Valere Tsouh Fokou, Benoît Laleu, James Duffy, Ozlem Tastan Bishop, Fabrice Fekam Boyom

Get full text

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus by Yaqing Jiao, Sarah Preston, Hongjian Song, Abdul Jabbar, Yuxiu Liu, Jonathan Baell, Andreas Hofmann, Dana Hutchinson, Tao Wang, Anson V. Koehler, Gillian M. Fisher, Katherine T. Andrews, Benoît Laleu, Michael J. Palmer, Jeremy N. Burrows, Timothy N. C. Wells, Qingmin Wang, Robin B. Gasser

Get full text

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a... by Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M.J. Koolen, Saman Honarnejad, Martijn W. Vos, Tonnie Huijs, Rob W.M. Henderson, Elodie Chenu, Benoît Laleu, Bailey C. Montefiore, Matthew D. Segall, James E.J. Mills, Eric M. Guantai, James Duffy, Maëlle Duffey

Get full text

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum by Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R. Luth, Johanna Hoshizaki, Mukul Rawat, Richard D. Pearson, Kyra A. Schindler, Sachel Mok, Heekuk Park, Anne-Catrin Uhlemann, Gouranga P. Jana, Bikash C. Maity, Benoît Laleu, Elodie Chenu, James Duffy, Sonia Moliner Cubel, Virginia Franco, Maria G. Gomez-Lorenzo, Francisco Javier Gamo, Elizabeth A. Winzeler, David A. Fidock, Thanat Chookajorn, Marcus C. S. Lee

Get full text

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation by Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S. Nasamu, Allison R. Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M. Early, Amanda K. Lukens, Danny Milner, Jeremy Furtado, Francisco-Javier Gamo, Elizabeth A. Winzeler, Sarah K. Volkman, Maëlle Duffey, Benoît Laleu, David A. Fidock, Susan Wyllie, Jacquin C. Niles, Dyann F. Wirth

Get full text

Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease by Paul Kelly, William A Petri, Rashidul Haque, Ibrahim A Khalil, Lynn Barrett, Tom Kennedy, Timothy Wells, Christopher D Huston, James Platts-mills, Grace S Yang, Richard Omore, Ian H Gilbert, Sumiti Vinayak, Boris Striepen, Ujjini H Manjunatha, Wesley C Van Voorhis, Samuel L M Arnold, Beatriz Baragana, Frederick S Buckner, Jeremy D Burrows, Maria A Caravedo, Ryan Choi, Robert K M Choy, Eugenio de Hostos, Thierry Diagana, Suzanne Duce, Matthew A Hulverson, Pui-Ying Iroh Tam, Minju Kim, Poonum Korpe, Benoît Laleu, Diana Lalika, Fabrice Laurent, Case W McNamara, Marvin J Meyers, Roberta M O’Connor, Kayode K Ojo, Philipp Olias, Nede Ovbiebo, Mattie C Pawlowic, Gladys Queen, Divya Rao, Kevin Reed, Michael W Riggs, Jennifer L Roxas, Adam Sateriale, Deborah A Schaefer, L David Sibley, Jonathan M Spector, Chris Tonkin, Timilehin E Toye, Saul Tzipori, A Clinton White

Get full text