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Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement. by Chortis, V, Taylor, A, Schneider, P, Tomlinson, J, Hughes, B, O'Neil, D, Libé, R, Allolio, B, Bertagna, X, Bertherat, J, Beuschlein, F, Fassnacht, M, Karavitaki, N, Mannelli, M, Mantero, F, Opocher, G, Porfiri, E, Quinkler, M, Sherlock, M, Terzolo, M, Nightingale, P, Shackleton, C, Stewart, P, Hahner, S, Arlt, W