The BTB-ZF transcription factors. by Siggs, O, Beutler, B

ZBTB1 is a determinant of lymphoid development. by Siggs, O, Li, X, Xia, Y, Beutler, B

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. by Siggs, O, Schnabl, B, Webb, B, Beutler, B

NOVEL LYMPHOCYTE DEFICIENCIES REVEALED BY MOUSE FORWARD GENETICS by Siggs, O, Bull, K, Beutler, B, Cornall, R

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. by Siggs, O, Cruite, J, Du, X, Rutschmann, S, Masliah, E, Beutler, B, Oldstone, M

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. by Siggs, O, Arnold, C, Huber, C, Pirie, E, Xia, Y, Lin, P, Nemazee, D, Beutler, B

iRhom2 is required for the secretion of mouse TNFα. by Siggs, O, Xiao, N, Wang, Y, Shi, H, Tomisato, W, Li, X, Xia, Y, Beutler, B

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation. by Won, S, Eidenschenk, C, Arnold, C, Siggs, O, Sun, L, Brandl, K, Mullen, T, Nemerow, G, Moresco, E, Beutler, B

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. by Arnold, C, Pirie, E, Dosenovic, P, McInerney, G, Xia, Y, Wang, N, Li, X, Siggs, O, Karlsson Hedestam, G, Beutler, B

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. by Brandl, K, Sun, L, Neppl, C, Siggs, O, Le Gall, S, Tomisato, W, Li, X, Du, X, Maennel, D, Blobel, C, Beutler, B

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. by Jiménez-Dalmaroni, M, Radcliffe, C, Harvey, D, Wormald, M, Verdino, P, Ainge, G, Larsen, D, Painter, G, Ulevitch, R, Beutler, B, Rudd, P, Dwek, R, Wilson, I

A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding. by Iavarone, C, Ramsauer, K, Kubarenko, A, Debasitis, J, Leykin, I, Weber, A, Siggs, O, Beutler, B, Zhang, P, Otten, G, D'Oro, U, Valiante, N, Mbow, M, Visintin, A

A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. by Siggs, O, Berger, M, Krebs, P, Arnold, C, Eidenschenk, C, Huber, C, Pirie, E, Smart, N, Khovananth, K, Xia, Y, McInerney, G, Karlsson Hedestam, G, Nemazee, D, Beutler, B

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. by Berger, M, Krebs, P, Crozat, K, Li, X, Croker, B, Siggs, O, Popkin, D, Du, X, Lawson, B, Theofilopoulos, A, Xia, Y, Khovananth, K, Moresco, E, Satoh, T, Takeuchi, O, Akira, S, Beutler, B

Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations by Bull, K, Rimmer, A, Siggs, O, Miosge, L, Roots, C, Enders, A, Bertram, E, Crockford, T, Whittle, B, Potter, P, Simon, M, Mallon, A, Brown, S, Beutler, B, Goodnow, C, Lunter, G, Cornall, R

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses. by Zak, D, Schmitz, F, Gold, E, Diercks, A, Peschon, J, Valvo, J, Niemistö, A, Podolsky, I, Fallen, S, Suen, R, Stolyar, T, Johnson, C, Kennedy, K, Hamilton, M, Siggs, O, Beutler, B, Aderem, A

RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. by Colak, E, Leslie, A, Zausmer, K, Khatamzas, E, Kubarenko, A, Pichulik, T, Klimosch, SN, Mayer, A, Siggs, O, Hector, A, Fischer, R, Klesser, B, Rautanen, A, Frank, M, Hill, A, Manoury, B, Beutler, B, Hartl, D, Simmons, A, Weber, A

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. by Siggs, O, Stockenhuber, A, Deobagkar-Lele, M, Bull, K, Crockford, T, Kingston, B, Crawford, G, Anzilotti, C, Steeples, V, Ghaffari, S, Czibik, G, Bellahcene, M, Watkins, H, Ashrafian, H, Davies, B, Woods, A, Carling, D, Yavari, A, Beutler, B, Cornall, R

ENU-induced phenovariance in mice: inferences from 587 mutations. by Arnold, C, Barnes, M, Berger, M, Blasius, A, Brandl, K, Croker, B, Crozat, K, Du, X, Eidenschenk, C, Georgel, P, Hoebe, K, Huang, H, Jiang, Z, Krebs, P, La Vine, D, Li, X, Lyon, S, Moresco, E, Murray, A, Popkin, D, Rutschmann, S, Siggs, O, Smart, N, Sun, L, Tabeta, K, Webster, V, Tomisato, W, Won, S, Xia, Y, Xiao, N, Beutler, B

Forward genetic analysis of mammalian immunity by Siggs, O, Owen Siggs

Other Authors: “…Beutler, B…”