Canadian healthcare capacity gaps for disease-modifying treatment in Huntington’s disease: a survey of current practice and modelling of future needs by Sylvain Chouinard, Blair R Leavitt, Angèle Bénard, Nathalie Budd, Jennifer W Wu, Kerrie Schoffer

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Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome by Benjamin Life, Luis E.B. Bettio, Ilse Gantois, Brian R. Christie, Blair R. Leavitt

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FTD-associated behavioural and transcriptomic abnormalities in ‘humanized’ progranulin-deficient mice: A novel model for progranulin-associated FTD by Benjamin Life, Terri L. Petkau, Giuliano N.F. Cruz, Erick I. Navarro-Delgado, Ning Shen, Keegan Korthauer, Blair R. Leavitt

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ABE8e Corrects Pax6-Aniridic Variant in Humanized Mouse ESCs and via LNPs in Ex Vivo Cortical Neurons by Bethany A. Adair, Andrea J. Korecki, Diana Djaksigulova, Pamela K. Wagner, Nina Y. Chiu, Siu Ling Lam, Tess C. Lengyell, Blair R. Leavitt, Elizabeth M. Simpson

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Progressive alterations in white matter microstructure across the timecourse of Huntington's disease by Carlos Estevez‐Fraga, Michael S. Elmalem, Marina Papoutsi, Alexandra Durr, Elin M. Rees, Nicola Z. Hobbs, Raymund A. C. Roos, Bernhard Landwehrmeyer, Blair R. Leavitt, Douglas R. Langbehn, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi, Sarah Gregory

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New MiniPromoter Ple389 (ADORA2A) drives selective expression in medium spiny neurons in mice and non-human primates by Alissandra de Moura Gomes, Terri L. Petkau, Andrea J. Korecki, Oriol Fornes, Adriana Galvan, Ge Lu, Austin M. Hill, Siu Ling Lam, Anqi Yao, Rachelle A. Farkas, Wyeth W. Wasserman, Yoland Smith, Elizabeth M. Simpson, Blair R. Leavitt

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Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice by Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt, Michael R. Hayden

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A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes by Marc Ciosi, Alastair Maxwell, Sarah A. Cumming, Davina J. Hensman Moss, Asma M. Alshammari, Michael D. Flower, Alexandra Durr, Blair R. Leavitt, Raymund A.C. Roos, Peter Holmans, Lesley Jones, Douglas R. Langbehn, Seung Kwak, Sarah J. Tabrizi, Darren G. Monckton

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