TNF as a therapeutic target by Bondeson, J, Feldmann, M, Maini, R

Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory media... by Bondeson, J, Foxwell, B, Brennan, F, Feldmann, M

Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines... by Bondeson, J, Brennan, F, Foxwell, B, Feldmann, M

Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumo... by Foxwell, B, Bondeson, J, Brennan, F, Feldmann, M

Reversible focal myositis in a patient taking venlafaxine. by Jewell, D, Thompson, I, Sullivan, B, Bondeson, J

Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo. by Yoshimura, S, Bondeson, J, Brennan, F, Foxwell, B, Feldmann, M

High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach. by Foxwell, B, Yoshimura, S, Bondeson, J, Brennan, F, Feldmann, M

Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI. by Yoshimura, S, Bondeson, J, Brennan, F, Foxwell, B, Feldmann, M

Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. by Yoshimura, S, Bondeson, J, Foxwell, B, Brennan, F, Feldmann, M

Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are N... by Amos, N, Lauder, S, Evans, A, Feldmann, M, Bondeson, J

Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB. by Calder, V, Bondeson, J, Brennan, F, Foxwell, B, Feldmann, M

Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory... by Bondeson, J, Browne, K, Brennan, F, Foxwell, B, Feldmann, M

The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha an... by Feldmann, M, Bondeson, J, Brennan, F, Foxwell, B, Maini, R

Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities. by Feldmann, M, Brennan, F, Bondeson, J, Paleolog, E, Foxwell, B, Maini, R

Cytokine blockade in rheumatoid arthritis. by Feldmann, M, Maini, R, Bondeson, J, Taylor, P, Foxwell, B, Brennan, F

Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanase... by Bondeson, J, Lauder, S, Wainwright, S, Amos, N, Evans, A, Hughes, C, Feldmann, M, Caterson, B

Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways. by Conron, M, Bondeson, J, Pantelidis, P, Beynon, H, Feldmann, M, duBois, R, Foxwell, B

Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent. by Foxwell, B, Browne, K, Bondeson, J, Clarke, C, de Martin, R, Brennan, F, Feldmann, M

Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? by Feldmann, M, Andreakos, E, Smith, C, Bondeson, J, Yoshimura, S, Kiriakidis, S, Monaco, C, Gasparini, C, Sacre, S, Lundberg, A, Paleolog, E, Horwood, N, Brennan, F, Foxwell, B