Drug Resistance Resulting from Kinase Dimerization Is Rationalized by Thermodynamic Factors Describing Allosteric Inhibitor Effects by Boris N. Kholodenko

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Navigating the multilayered organization of eukaryotic signaling: a new trend in data integration. by Tapesh Santra, Walter Kolch, Boris N Kholodenko

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Performance of objective functions and optimisation procedures for parameter estimation in system biology models by Andrea Degasperi, Dirk Fey, Boris N. Kholodenko

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Positional information generated by spatially distributed signaling cascades. by Javier Muñoz-García, Zoltan Neufeld, Boris N Kholodenko

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Versatility of cooperative transcriptional activation: a thermodynamical modeling analysis for greater-than-additive and less-than-additive effects. by Till D Frank, Aimée M Carmody, Boris N Kholodenko

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Crosstalk and signalling switches in mitogen-activated protein kinase cascades by Dirk eFey, David R Croucher, Walter eKolch, Boris N Kholodenko

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Evaluating strategies to normalise biological replicates of Western blot data. by Andrea Degasperi, Marc R Birtwistle, Natalia Volinsky, Jens Rauch, Walter Kolch, Boris N Kholodenko

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Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system. by Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko

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Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses by Marc R Birtwistle, Mariko Hatakeyama, Noriko Yumoto, Babatunde A Ogunnaike, Jan B Hoek, Boris N Kholodenko

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The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts by Je-Hoon Song, David J. Huels, Rachel A. Ridgway, Owen J. Sansom, Boris N. Kholodenko, Walter Kolch, Kwang-Hyun Cho

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Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells by Thomas Sevrin, Hiroaki Imoto, Sarah Robertson, Nora Rauch, Uscinnia Dyn’ko, Katerina Koubova, Kieran Wynne, Walter Kolch, Oleksii S. Rukhlenko, Boris N. Kholodenko

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SARAH Domain-Mediated MST2-RASSF Dimeric Interactions. by Goar Sánchez-Sanz, Bartłomiej Tywoniuk, David Matallanas, David Romano, Lan K Nguyen, Boris N Kholodenko, Edina Rosta, Walter Kolch, Nicolae-Viorel Buchete

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Frequency modulation of ERK activation dynamics rewires cell fate by Hyunryul Ryu, Minhwan Chung, Maciej Dobrzyński, Dirk Fey, Yannick Blum, Sung Sik Lee, Matthias Peter, Boris N Kholodenko, Noo Li Jeon, Olivier Pertz

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Frequency modulation of ERK activation dynamics rewires cell fate by Hyunryul Ryu, Minhwan Chung, Maciej Dobrzyński, Dirk Fey, Yannick Blum, Sung Sik Lee, Matthias Peter, Boris N Kholodenko, Noo Li Jeon, Olivier Pertz

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A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression by Hiroaki Imoto, Nora Rauch, Ashish J. Neve, Fahimeh Khorsand, Martina Kreileder, Leonidas G. Alexopoulos, Jens Rauch, Mariko Okada, Boris N. Kholodenko, Oleksii S. Rukhlenko

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Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling by Nikolay Borisov, Edita Aksamitiene, Anatoly Kiyatkin, Stefan Legewie, Jan Berkhout, Thomas Maiwald, Nikolai P Kaimachnikov, Jens Timmer, Jan B Hoek, Boris N Kholodenko

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Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration by Alfonso Bolado-Carrancio, Oleksii S Rukhlenko, Elena Nikonova, Mikhail A Tsyganov, Anne Wheeler, Amaya Garcia-Munoz, Walter Kolch, Alex von Kriegsheim, Boris N Kholodenko

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Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation. by Malgorzata Milewska, David Romano, Ana Herrero, Maria Luisa Guerriero, Marc Birtwistle, Franz Quehenberger, Stefan Hatzl, Boris N Kholodenko, Oreste Segatto, Walter Kolch, Armin Zebisch

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Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor. by Keesha E Erickson, Oleksii S Rukhlenko, Md Shahinuzzaman, Kalina P Slavkova, Yen Ting Lin, Ryan Suderman, Edward C Stites, Marian Anghel, Richard G Posner, Dipak Barua, Boris N Kholodenko, William S Hlavacek

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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis by Sujoy Chatterjee, Shivraj M. Yabaji, Oleksii S. Rukhlenko, Bidisha Bhattacharya, Emily Waligurski, Nandini Vallavoju, Somak Ray, Boris N. Kholodenko, Lauren E. Brown, Aaron B. Beeler, Alexander R. Ivanov, Lester Kobzik, John A. Porco, Jr., Igor Kramnik

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